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![Detoxification mechanism of selenium yeast on mycotoxins and heavy metals poisoning [140]. The symbol “→” indicates activation and “⟞” indicates inhibition. The red arrow indicates that the concentration or level of the indicator increases or rises, while the green arrow indicates that the concentration or level of the indicator decreases or falls](publication/367302539/figure/fig3/AS:11431281189837920@1695176843727/Detoxification-mechanism-of-selenium-yeast-on-mycotoxins-and-heavy-metals-poisoning.png)
Detoxification mechanism of selenium yeast on mycotoxins and heavy metals poisoning [140]. The symbol “→” indicates activation and “⟞” indicates inhibition. The red arrow indicates that the concentration or level of the indicator increases or rises, while the green arrow indicates that the concentration or level of the indicator decreases or falls
Source publication
Mycotoxins are secondary metabolites produced by specific fungi. More than 400 different mycotoxins are known in the world, and the concentration of these toxins in food and feed often exceeds the acceptable limit, thus causing serious harm to animals and human body. At the same time, modern industrial agriculture will also bring a lot of environme...
Similar publications
Selenium is an integral component of vital biologically active compounds of the human body. Currently, the population of many countries is characterized by selenium deficiency. In this regard, many preparations of inorganic and organic forms of selenium have been developed. Nevertheless, it is evident that the most effective solution to the problem...
Citations
... Selenium yeast (Se-Y) is an organic selenium source developed from yeast [9]. Compared with inorganic selenium, the absorption rate of organic selenium by animals is higher [9]. ...
... Selenium yeast (Se-Y) is an organic selenium source developed from yeast [9]. Compared with inorganic selenium, the absorption rate of organic selenium by animals is higher [9]. Selenium has anti-inflammatory and antioxidant functions [10], and selenium deficiency can cause the accumulation of reactive oxygen species in organisms and eventually lead to inflammation. ...
The purpose of this study was to explore the effects of MSM and Se-Y on FLS in laying hens during the late peak laying period and the underlying biological mechanisms. Therefore 240 55-week-old Jing-fen No. 6 laying hens were randomly divided into five groups, with eight replicates in each group and six laying hens in each replicate. The hens were fed a basal diet (Control) and diets supplemented with 350 and 700 mg/kg MSM and 25 and 50 mg/kg Se-Y, respectively, for four weeks. The results showed that MSM and Se-Y had no significant effects on the performance of laying hens. With the increasing dosage of MSM and Se-Y, the symptoms of liver steatosis in laying hens were reduced, and MSM and Se-Y could significantly reduce the content of malondialdehyde (MDA) in serum and liver (p < 0.05) and increase the contents of total superoxide dismutase (T-SOD) and glutathione peroxidase (GPX) in serum and liver (p < 0.05). The RNA-seq results showed that 700 mg/kg MSM significantly downregulated the expression levels of the ATP5I, ATP5G1, CYCS, and UQCRQ genes in the liver, and 50 mg/kg Se-Y significantly downregulated the expression levels of MAPK10, SRC, BMP2, and FGF9 genes in the liver. In conclusion, dietary supplementation with MSM and Se-Y can effectively reduce the FLS of laying hens in the late peak laying period and increase their antioxidant capacity. The underlying biological mechanism may be related to the downregulation of genes involved in liver oxidative phosphorylation and inflammation-related pathways.
Zusammenfassung
Selen ist ein essenzielles Spurenelement, das im Körper in Form von Selenoproteinen verschiedene physiologische Funktionen erfüllt. Die Hauptform des Selens im Blutplasma ist das Selenoprotein P (SELENOP). Neben seiner Funktion als wichtigster Transporter im Körper übernimmt es auch Speicher- und Verteilerfunktionen. Eine niedrige Konzentration an SELENOP wurde als Risikofaktor für eine Reihe verschiedener Erkrankungen und generell mit verringerter Lebenserwartung assoziiert. Auch beim Selenmangel gibt es einige Gesundheitsrisiken. Der Ausgleich eines Selendefizits ist relativ einfach und kann durch eine bessere Versorgung erfolgen.
Numerous antibiotic resistance genes (ARGs) and virulence factors (VFs) found in animal manure pose significant risks to human health. However, the effects of graphene sodium selenite (GSSe), a novel chemical nano-Selenium, and biological nano-Selenium (BNSSe), a new bioaugmentation nano-Se, on bacterial Se metabolism, chemotaxis, ARGs, and VFs in animal manure remain unknown. In this study, we investigated the effects of GSSe and BNSSe on ARGs and VFs expression in broiler manure using high-throughput sequencing. Results showed that BNSSe reduced Se pressure during anaerobic fermentation by inhibiting bacterial selenocompound metabolism pathways, thereby lowering manure Selenium pollution. Additionally, the expression levels of ARGs and VFs were lower in the BNSSe group compared to the Sodium Selenite and GSSe groups, as BNSSe inhibited bacterial chemotaxis pathways. Co-occurrence network analysis identified ARGs and VFs within the following phyla Bacteroidetes (genera Butyricimonas, Odoribacter, Paraprevotella, and Rikenella), Firmicutes (genera Lactobacillus, Candidatus_Borkfalkia, Merdimonas, Oscillibacter, Intestinimonas, and Megamonas), and Proteobacteria (genera Desulfovibrio). The expression and abundance of ARGs and VFs genes were found to be associated with ARGs-VFs coexistence. Moreover, BNSSe disruption of bacterial selenocompound metabolism and chemotaxis pathways resulted in less frequent transfer of ARGs and VFs. These findings indicate that BNSSe can reduce ARGs and VFs expression in animal manure by suppressing bacterial selenocompound metabolism and chemotaxis pathways.
