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Dermoscopic scores of the pigmentary and vascular elements in melasma at week 0 and week 16 in the 1064 nm picosecond ND-YAG laser group.
Source publication
Melasma is a challenging pigmentation disorder to treat, and although low-fluence 1064 nm picosecond ND-YAG lasers have shown potential for treating benign pigmented disorders, data on the use of this laser for melasma treatment are currently insufficient. In this prospective split-face study, twenty-four patients with melasma on the face were enro...
Citations
... No statistically significant difference in patient satisfaction at 12 week of follow up and no adverse effects were observed. Lee et al., 2023), (Wu et al., 2020), (Wong et al., 2021), (Chalermchai & Rummaneethorn, 2017) จากข ...
Abstract
Melasma is one of the most common aesthetic problems that affect patients’ quality
of life. The purpose of this study is to evaluate the efficacy of melasma treatment with
a combination of 1064 PICO laser and 3% tranexamic acid compared with 3% tranexamic acid
alone.
This study is a prospective, randomized, assessor blinded study of volunteered
melasma cases. The patient's faces were divided into 2 sides and were randomly treated with
PICO laser and tranexamic acid on one side and only with tranexamic acid on the other.
PICO laser sessions were conducted 3 times in a 4-week interval and the tranexamic acid was
applied twice daily for 12 weeks.
A total number of 21 patients were included in this study. The result of mMASI score
and melatonin index in the combination of PICO and tranexamic acid group is statistically
lower compared with the other group at 8 weeks and 12 weeks of follow up. However, the
result shows that both groups had statistically significantly improved in mMASI score and
melatonin index after 12 weeks of follow up. No statistically significant difference in patient
satisfaction at 12 week of follow up and no adverse effects were observed.
Keywords: melasma, picosecondlaser, tranexamic acid
