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Demonstrator pipe organ by Principal Pipe Organs of York, UK consisting of a pipe for one note (G4) of each of the following stops labelled numerically: (1) Open Diapason 8’, (2) Principal 4’, (3) Twelfth 2 2 / 3 ’, (4) Fifteenth 2’, (5) Tierce 1 3 / 5 ’, (6) Larigot 1 1/3’, (7) Septième 1 1 / 7 , (8) Octavin 1’, (9) Hohl Flute 8’, (10) Block Flute 4’, (11) Piccolo 2’, (12) Salicional 8’, 

Demonstrator pipe organ by Principal Pipe Organs of York, UK consisting of a pipe for one note (G4) of each of the following stops labelled numerically: (1) Open Diapason 8’, (2) Principal 4’, (3) Twelfth 2 2 / 3 ’, (4) Fifteenth 2’, (5) Tierce 1 3 / 5 ’, (6) Larigot 1 1/3’, (7) Septième 1 1 / 7 , (8) Octavin 1’, (9) Hohl Flute 8’, (10) Block Flute 4’, (11) Piccolo 2’, (12) Salicional 8’, 

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Public engagement with science, technology, and engineering is seen as being increasingly important as the numbers of school leavers choosing to read for degrees in these areas is typically dropping. Engagement with pupils during their school years is seen as being a key element in influencing their choices of career for which seeds are sown from t...

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... to the sound modifier tubes. The VTM-10 kit sound modifiers are provided in two forms as follows. There are five acrylic tubes representing in cylindrical cross-section the oral tract for the vowels /i/, /e/, /a/, /o/ and /u/ with hard rubber couplers to connect either of the two sound sources. In addition, there is a set of acrylic squares with central holes of various diameters and these can be placed together on a special frame to enable other vocal tract shapes to be made up. This too has a hard rubber coupler to link it to either of the two sound sources. Arai [8] also proposes the use of a horn loudspeaker driver unit and he provides a description of a suitable design for a hard rubber coupler, so that it can be used as an electrical driver to enable any signal to be used as excitation such as a pulse train, white noise or the L/F source model [9] that is commonly found in practical electronic synthesis systems such as the Klatt synthesizer [10]. Three oral tract tubes and the sound sources from the VMT-10 kit are shown in figure 1a. A rather crude power source and sound source model can be fashioned out of a two litre plastic drinks bottle, three plastic sandwich bags, plastic insulating tape, plastic tubing with a “T” piece and a whistle-type artificial larynx from the VTM-10 kit [8]. The “T” piece is fitted to the end of the plastic tube and a plastic sandwich bag is fitted on each of the two branches of the “T” to be airtight. These are the “lungs”. The bottom of the bottle is cut off and its screw-top is removed. A hole is made through the screw-top that will be a snug fit for the plastic tube. The top is screwed back onto the bottle and the tube with the “T” piece and bags attached is drawn through the lid until the “T” piece and bags are in the middle of the bottle. The third plastic bag, which will be the “diaphragm” is fitted around the bottom of the bottle and taped in place such that it is very loose but airtight. The top of the bottle is unscrewed a little and the diaphragm is pushed into the bottom of the bottle and the top is tightened. This is the “raised diaphragm” position. The “lungs” should be deflated by sucking on the end of the plastic tube, and then the artificial larynx is fixed to the far end of the tube, outside the bottle. The lung model is shown in figure 1b. Breathing in is achieved by gently grasping the centre of the “diaphragm” and pulling it gently away from the bottle. The “lungs” should inflate”. On breathing out by pushing the “diaphragm” into the bottom of the bottle, a sound is heard from the artificial larynx. A hose from the oil heat exchanger from a Toyota 4by4 vehicle is about the right diameter for a fully open vocal tract and it also has a curve in it or about the right radius for the oral cavity. When placed over a small loudspeaker unit that includes a suitable electronic oscillator (pulse-like wave shape with amplitude and f0 control (varying between approximately 80 to 400 Hz), the effects of the sound source and sound modifiers can be demonstrated. A duck call makes a good sound source and a 17.5 cm piece of soft-walled rubber tubing fitted over the end provides a demonstration vocal tract. Both are shown in figure 1b. A tilting paper larynx model can be made by following on-line instructions [11] and this design has been used for a tilting aluminium version that is around 25cm tall onto which rubber bands can be fixed to show how the vocal folds are stretched as the larynx is tilted (see figure 1c). Medical models of the lungs, bronchi, larynx, vocal tract and cut-away details of the head can be used to enhance understanding of human voice production in a graphical and hands-on manner. A replica by Principal Pipe Organs of York, UK of the von Kempelin [12] speaking machine of 1793 (figure 1d) is very useful as a voice production demonstration device not only because for its historical interest, but also because it is visually rather appealing as a model of the power source, sound source and sound modifiers. Harmonic synthesis can be readily demonstrated on a computer using a freeware resource such as Pure Data, or PD , [13] or with a purpose-implemented iPad Application such as “Harmonic Synthesis” [14], but the use of organ pipes makes for a much more physical and tangible acoustic experience. A pipe organ is an acoustic harmonic synthesizer. The stops on an organ enable the player to create different sounds through harmonic synthesis, since the majority of the stops themselves are directly related to harmonics. Most of the stops have a footage associated with them which indicates the pitch at which that particular rank of pipes plays in relation to the overall f0 of the sound. A stop with an 8 on it indicates that the pipe for the lowest note (two octaves below middle C - the bottom note on an organ keyboard) is approximately 8 feet long, and such a stop plays at concert pitch. In other words, the notes sound at the same pitch as the piano. Figure 2 shows a pipe organ demonstrator built by Principal Pipe Organs of York, UK for a single note which has 16 stops with one pipe for each stop. It is designed to demonstrate different types of organ pipes and acoustic synthesis using harmonics 1-8. There are two main types of organs pipe: flues and reeds. The demonstrator has 13 flue pipes (harmonics 1-8 based essentially on principal pipes, harmonics 1-3 based on stopped flute pipes, and two pipes that are slightly de-tuned to create a string sound – Salicional and Voix Celeste ) and three reed pipes (oboe, trumpet and cornopean). The principal and string pipes are open and the flute pipes are closed (the stoppers in their ends are visible in the figure). Each pipe can be played separately or in any combination by means of small brass buttons. Work with the cup and string communicator offers an opportunity to illustrate the potential for disruption due to competing acoustic noise and the acoustics of the space. If a class is trying to communicate a message using this system and they are all in the same room, preferably a reverberant hall, then the speakers will end up raising their voices in order to be heard. Thus the background noise will be increased to a high level and the point can be made that this is something of a vicious circle – one speaker’s voice is raised increasing the noise level for everyone else so other speakers do so too and the level rises to an equilibrium level of sorts where speakers are shouting. At this point, it is perhaps worth pointing out that the cup and string can potentially become redundant because the source level is high enough to be heard without it if it weren’t for the background noise and room reverberation. Room reverberation can be isolated by listening to a hand clap which offers an opportunity for explaining the importance of careful listening and the use of an impulse (hand clap) to test informally the acoustics of spaces. The effect can be enhanced in terms of level by organising the group to clap in unison together after, say, a count of three. This develops coordination skills, group effort and a useful musical skill. It is worth noting that many singers, speakers and musicians, use a hand clap to test the acoustics of performance spaces during rehearsals to determine good performance positions, and these are not always centre stage or behind a speaker’s lectern [6]. The presence of background noise and the effects of room acoustics are good examples of interfering unwanted signals for a communication system. To make the effects of these even more pronounced practically with a group studying a foreign language, set up the cup and string pairs down the long axis of a room. Those at one end of the room will be the speakers and those at the other end will be the listeners. The speakers will be given a message on paper which the listeners have to write down. What you do not tell them is that the messages are in another language, albeit but one that they are studying. Use has been made of French and Latin phrases in this way in a local school where these languages are studied (the messages were composed by one of their teachers to ensure that it would be well within the capabilities of the pupils to understand and translate the sentences). Insist that all communication between the speakers and listeners must be done using the cup and string apparatus and give out the messages. The background noise tends to rise extremely quickly during these sessions and many attempts are required before the listeners receive a useful message. Swap speakers and listeners and give out another set of messages again in the foreign language and the task is completed more quickly. To end, bring the group together, preferably with the teacher who wrote the sentences present, and ask each to read out the message they received as listener and offer a translation. Ask the speaker to confirm or otherwise the message content and translation (the teacher may well intervene at this point!). Typically for the first group of listeners, the heard versions are incomplete sentences. Indeed, on one occasion a Latin transmitted sentence was received as a French sentence! Here are some example sentences and their translations in ...

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... The possibility of handling and manipulating anatomical structures (in 3D printed form or within virtual and/or augmented reality) is a well-proven and rewarding way of gaining enhanced and more in-depth understanding of the function of component parts 55,56 as well as raising awareness in the public and future generations of researchers. 57 ...
Article
Objectives MRI based vocal tract models have many applications in voice research and education. These models do not adequately capture bony structures (e.g. teeth, mandible), and spatial resolution is often relatively low in order to minimize scanning time. Most MRI sequences achieve 3D vocal tract coverage at gross resolutions of 2 mm³ within a scan time of <20 seconds. Computed tomography (CT) is well suited for vocal tract imaging, but is infrequently used due to the risk of ionizing radiation. In this cadaveric study, a single, extremely low-dose CT scan of the bony structures is blended with accelerated high-resolution (1 mm³) MRI scans of the soft tissues, creating a high-resolution hybrid CT-MRI vocal tract model. Methods Minimum CT dosages were determined and a custom 16-channel airway receiver coil for accelerated high (1 mm³) resolution MRI was evaluated. A rigid body landmark based partial volume registration scheme was then applied to the images, creating a hybrid CT-MRI model that was segmented in Slicer. Results Ultra-low dose CT produced images with sufficient quality to clearly visualize the bone, and exposed the cadaver to 0.06 mSv. This is comparable to atmospheric exposures during a round trip transatlantic flight. The custom 16-channel vocal tract coil produced acceptable image quality at 1 mm³ resolution when reconstructed from ∼6 fold undersampled data. High (1 mm³) resolution MR imaging of short (<10 seconds) sustained sounds was achieved. The feasibility of hybrid CT-MRI vocal tract modeling was successfully demonstrated using the rigid body landmark based partial volume registration scheme. Segmentations of CT and hybrid CT-MRI images provided more detailed 3D representations of the vocal tract than 2 mm³ MRI based segmentations. Conclusions The method described in this study indicates that high-resolution CT and MR image sets can be combined so that structures such as teeth and bone are accurately represented in vocal tract reconstructions. Such scans will aid learning and deepen understanding of anatomical features that relate to voice production, as well as furthering knowledge of the static and dynamic functioning of individual structures relating to voice production.
... Howard 1 notes the link here with the work of Von Kempelen in the 1790s with his speaking machines 5 that are physically controlled for sound output by squeezing a bellows under an arm. This has been part of the on-going inspiration for this work in the context of the nature of a direct human interface to control the voice output as well as for encouraging more young people into STEM studies and careers (eg, 6 ). The original background and design philosophy behind the Vocal Tract Organ was to make use of three-D printed vocal tracts for different vowels that are placed atop a horn driver 16-ohm, 60-Watt loudspeaker (Adastra model 952.210), a loudspeaker that was designed to screw into the end of a horn resonator that is typically employed for outdoor use in public address systems as well as vans used for advertising, canvassing and selling ice creams. ...
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Objectives The Vocal Tract Organ has had a number of iterations resulting from advances in available technology as well as requirements of perceptual experiments and performance paradigms. The objective of this paper is to relate the development history of the Vocal Tract Organ from the original vision to what it is today as a modern version of the Vox Humana pipe organ stop for application in voice production and perception research. Study Design Descriptive Methods/design The latest Vocal Tract Organ is a polyphonic eight-channel eight-stop one manual Vocal Tract Organ that enables tab stop selected three-D printed vocal tracts to be used to create sound. This version includes eight stops (four for female vowel oral tracts and four for male vowel oral tracts). The stops are implemented using conventionally engraved pipe organ stop tabs labeled “Vox Humana Female” or “Vox Humana Male” followed by the three-D printed vowel: “EE”, “AH”, “ER” or “UU.” This is described alongside the development stages from which it emerged and covers all previous versions of the Vocal Tract Organ. At the heart of the latest instrument is a Bela BeagleBone Black with a Bela cape audio expander board which incorporates eight 16-bit audio outputs at 44.1 kHz sampling rate (earlier versions based on the Arduino Mega board were limited to 8-bit audio at an audio sampling rate of 16.384 kHz which limited the overall output spectrum). The latest Vocal Tract Organ is programmed using the audio graphical programming language Pure Data which is directly compatible with the Bela system. The Pure Data patch creates eight larynx outputs at the pitches set by the keys depressed on the keyboard and these are routed to Vocal Tract Organ loudspeakers with three-D printed vocal tracts attached. Results The Bela system has enabled real-time synthesis of eight-note polyphonic sounds to eight separate three-D printed vocal tracts, each being selectable via an organ tab stop switch. The instrument has been cased in a purpose-designed and built prototype laser-cut enclosure that incorporates the eight tab stops, a MIDI keyboard input, a pipe organ style swell (volume) pedal connection, four stereo (eight channels) audio amplifiers and terminal connections for the eight loudspeakers. Conclusions The Vocal Tract Organ functions as a musical instrument for performance and as an instrument for vowel and pitch perception research. Implementing it with the Bela family of processors allows for low audio latency of 1 ms and rapid prototyping due to being able to program directly with the high-level graphical audio programming language, Pure data (Pd).
... However, a key difference is that they were manipulating the shape of the vocal tract as mechanical analogues of the human speech production system to create dynamic variations to simulate running speech. The author has a modern replica of a von Kempelen speaking machine (see figure 1) which is used for demonstrating voice production; the visual, tangible and rather unusual nature of such demonstrations is an important aspect for engaging those new to the field of speech and singing science [15]. ...
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The advent and now increasingly widespread availability of 3-D printers is transforming our understanding of the natural world by enabling observations to be made in a tangible manner. This paper describes the use of 3-D printed models of the vocal tract for different vowels that are used to create an acoustic output when stimulated with an appropriate sound source in a new musical instrument: the Vocal Tract Organ. The shape of each printed vocal tract is recovered from magnetic resonance imaging. It sits atop a loudspeaker to which is provided an acoustic L-F model larynx input signal that is controlled by the notes played on a MIDI (musical instrument digital interface) device such as a keyboard. The larynx input is subject to vibrato with extent and frequency adjustable as desired within the ranges usually found for human singing. Polyphonic inputs for choral singing textures can be applied via a single loudspeaker and vocal tract, invoking the approximation of linearity in the voice production system, thereby making multiple vowel stops a possibility while keeping the complexity of the instrument in reasonable check. The vocal tract organ offers a much more human and natural sounding result than the traditional Vox Humana stops found in larger pipe organs, offering the possibility of enhancing pipe organs of the future as well as becoming the basis for a 'multi-vowel' chamber organ in its own right.
... V ocal folds are soft connective tissues that effectively convert aerodynamic energy to audible pulses for sound production. 1,2 Vocal folds are composed of a stratified squamous epithelium, a matrix-rich lamina propria (LP), and the vocalis muscle. Adult human vocal fold LP is a highly organized and complex structure, consisting of a superficial layer (SLP) lacking mature collagen and elastin fibers, an intermediate layer (ILP) rich in elastin and hyaluronic acid (HA), and a deep layer (DLP) with abundant collagen fibers and other interstitially dispersed proteoglycans. 3 While the SLP is essential for the free flow of the mucosal wave, the vocal ligament, ILP, and DLP combined, provides sufficient strength to the tissue during phonation. ...
... Adult vocal folds experience a broad frequency range (100-300 Hz) and sustain strains up to 30% during normal phonation. 1,2 Human vocal folds are frequently exposed to numerous insults, such as voice abuse, infections, or chemical irritants. Once these physiological provocations exceed the tissue's healing capacity, vocal scarring or dysphonia occurs. ...
... Vocal fold scarring is associated with altered matrix composition and tissue mechanics, therefore compromising the SLP's ability to propagate the mucosal wave during phonation. [2][3][4] Stem cell-based tissue engineering strategy has emerged as a promising alternative approach for vocal fold restoration. 5 Mesenchymal stem cells (MSCs) have been widely employed as the therapeutic cells for a variety of regenerative medicine applications. ...
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Vocal fold disorders affect 3-9% of the U.S. population. Tissue engineering offers an alternative strategy for vocal fold repair. Successful engineering of vocal fold tissues requires a strategic combination of therapeutic cells, biomimetic scaffolds and, physiologically relevant mechanical and biochemical factors. Specifically we aim to create a vocal fold-like microenvironment to coax stem cells to adopt the phenotype of vocal fold fibroblasts (VFFs). Herein, high frequency vibratory stimulations and soluble connective tissue growth factor (CTGF) were sequentially introduced to mesenchymal stem cells (MSCs) cultured on a poly(ε-caprolactone) (PCL)-derived microfibrous scaffold for a total of six days. The initial 3-day vibratory culture resulted in an increased production of hyaluronic acids (HA), tenascin-C (TNC), decorin (DCN) and matrix metalloproteinase-1 (MMP1). The subsequent 3-day CTGF treatment further enhanced the cellular production of TNC and DCN, whereas CTGF treatment alone without the vibratory preconditioning significantly promoted the synthesis of collagen I (Col 1) and sulfated glycosaminoglycans (sGAGs). The highest level of MMP1, TNC, Col III and DCN production was found for the cells being exposed to the combined vibration and CTGF treatment. Noteworthy, the vibration and CTGF elicited a differential stimulatory effect on elastin (ELN), HA synthase 1 (HAS1) and fibroblast specific protein-1 (FSP-1). The mitogenic activity of CTGF was only elicited in naïve cells without the vibratory preconditioning. The combined treatment had profound, but opposite effects on mitogen activated protein kinase (MAPK) pathways, Erk1/2 and p38, and the Erk1/2 pathway was critical for the observed mechano-biochemical responses. Collectively, vibratory stresses and CTGF signals cooperatively coaxed MSCs toward a vocal fold fibroblast-like phenotype and accelerated the synthesis and remodeling of vocal fold matrices.
Article
With a general decline in people's choosing to pursue science and engineering degrees there has never been a greater need to raise the awareness of lesser known fields such as acoustics. Given this context, a large-scale public engagement project, the 'Aeolus project', was created to raise awareness of acoustics science through a major collaboration between an acclaimed artist and acoustics researchers. It centred on touring the large singing sculpture Aeolus during 2011/12, though the project also included an extensive outreach programme of talks, exhibitions, community workshops and resources for schools. Described here are the motivations behind the project and the artwork itself, the ways in which scientists and an artist collaborated, and the public engagement activities designed as part of the project. Evaluation results suggest that the project achieved its goal of inspiring interest in the discipline of acoustics through the exploration of an otherworldly work of art.