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Purpose. To retrospectively study the effect of fish oil-based lipid emulsion and soybean oil-based lipid emulsion on cholestasis associated with long-term parenteral nutrition in premature infants. Methods. Soybean oil-based lipid emulsion and fish oil-based lipid emulsion had been applied in our neonatology department clinically between 2010 and...
Contexts in source publication
Context 1
... oil group was made up of 32 premature infants, while fish oil group was made up of 29 premature infants. Chi- square test analysis showed that there were no differences in terms of gender, feeding intolerance, and the incidence of infection history in the two groups (Table 1). í µí±¡-test analysis between the two groups showed no difference in birth weight, gestational age, age at which feeding began, or the days of life of occurrence of cholestasis (Table 1). ...
Context 2
... square test analysis showed that there were no differences in terms of gender, feeding intolerance, and the incidence of infection history in the two groups (Table 1). í µí±¡-test analysis between the two groups showed no difference in birth weight, gestational age, age at which feeding began, or the days of life of occurrence of cholestasis (Table 1). And no significant difference was found in the administration of intravenous nutrition in the two groups (Table 2), indicating good comparability between the two groups. ...
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Background
Liver transplantation (LT) is one of the widely recognised and leading treatments for end-stage liver disease. Nutrition impacts its success. Total parenteral nutrition (TPN) is usually prescribed for patients recommended prolonged fasting after LT. The supplement of SMOFlipid (soybean oil, MCT oil, olive oil, and fish oil) is easily met...
Citations
... Riedy et al. [45] also used relative high Effect of a fish oil-based lipid emulsion dose of fish oil (1.5 g/kg/day) to treat a severely malnourished neonates and proposed that appropriate doses of fish oil may assist in the prevention of EFAD. FO has not been consistently effective in reversing PN-related cholestasis [46]. Low body weight, age, presence of severe liver disease, and mechanical ventilation may affect the efficacy of fish oil therapy in children [47]. ...
... Even though fish oil may be beneficial in patients with cholestasis, it fails to stop the progression of liver fibrosis, which leads to end-stage liver disease [48]. Wang et al. [46] reported that there was no difference between fish oil and soybean oil on PN-related cholestasis treatment in prematurity on long-term PN. Physicians are still trying to identify the most appropriate doses of fish oil. ...
Background/objectives:
The aim of this study was to assess the effects of a fish oil-based lipid emulsion on intestinal failure-associated liver disease (IFALD) in children.
Subjects/methods:
From January 2014 through June 2017, we enrolled 32 children with IF on long-term parenteral nutrition (PN). When the levels of any three of seven liver indicators (TBA, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, gamma glutamyl transferase (γ-GT), total bilirubin (TB), or direct bilirubin (DB)) were two times higher than normal levels, we switched a 50:50 mix of soybean oil and medium-chain triglycerides (MCT) lipid emulsion (with an average dose of 1.30 g/kg/day) to a fish oil-based lipid emulsion (1 g/kg/day) and measured liver function in the children. Meanwhile, inflammation and oxidative stress-related markers were also measured.
Results:
The average fish oil therapy duration was 26 ± 21 days, and the median duration of PN support was 84 days. With fish oil therapy, levels of TBA, ALT, AST, γ-GT, TB, and DB all significantly decreased. Enteral nutrition was introduced following fish oil resulting in higher energy intake (99.88 ± 31.06 kcal/kg/day) compared with before fish oil (67.90 ± 27.31 kcal/kg/day, P = 0.001). No significant difference was found in average PN energy (P = 0.147). In addition, levels of inflammatory indicators like tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), and white blood cell (WBC) significantly decreased.
Conclusions:
Fish oil therapy alleviates IFALD in children.
lipids (fats and oils) are a concentrated source of energy in poultry diets that improves palat-ability, feed consistency, provides essential fatty acids and increases the absorption of fat-soluble vitamins. fresh oil is an expensive energy source and its exposure to air, heat, metallic catalyst during storage and processing may lead to its oxidative deterioration. this review highlights the response of modern poultry to dietary oxidized oil on growth performance, nutrients digestibil-ity, gut health, carcass characteristics, meat quality, blood chemistry and tissue oxidative status. literature shows that in moderately (peroxide value (pv): 20 to 50 meq kg-1) and highly (pv: 50 to 100 meq kg-1 or above) oxidized oils, lipid peroxidation causes rancid odours and flavours that negatively affect feed palatability, reduces intestinal villus height that decreases the surface area available for nutrients absorption. the oxidation products also damage fat soluble vitamins (a, d, E and K) in blood resulting in an oxidative stress. the use of oxidized oil in poultry diets has no significant effect on dressing percentage, pH and meat colour, whereas carcass weight decreases and drip loss of meat increases. Overall, there is a contradictory data regarding the influence of oxidized oil in poultry feed depending on the pv and inclusion levels. the reviewed literature shows that the use of mildly oxidized (pv<20 meq kg-1) oil in poultry feed with 4 to 5% inclusion level decreases the feed cost and ultimately cost of poultry production without compromising their growth performance. It can, therefore, partially replace fresh oil as an efficient, cost effective and sustainable energy source in poultry diets. Carbohydrates and lipids (fats and oils) are the main energy sources in poultry ration. Lipids provide about 2.25 times greater energy compared with carbohydrates
This study was conducted to evaluate the effects of hydroalcoholic leaf extract of Withania somnifera (WS) and α-tocopherol acetate (α-Toc) in the diets containing oxidised oil on the growth performance, immune response, and oxidative status in the broiler chickens. A 3-way factorial design (2 × 3 × 2) was applied consisting of the oxidised oil (0 and 2%), WS (0, 100 and 200 mg/kg diet), and α-Toc (0 and 200 mg/kg). In total, 600 one-day-old male broilers were randomly subjected to 12 treatments with 5 replicates (10 birds/replicate). Broilers were provided with feed and water ad libitum during the 42-day experimental period. On day 42, one bird per each replicate was killed to measure the lymphoid organ weights, intestinal morphometric parameters, and MDA content in the thigh meat. Dietary oxidised oil reduced the FI, and BWG (p
Lipids (fats and oils) are concentrated source of energy in poultry diets that improves palatability, feed consistency, provides essential fatty acids and increases the absorption of fat-soluble vitamins. Fresh oil is an expensive energy source and its exposure to air, heat, metallic catalyst during storage and processing may lead to its oxidative deterioration. This review highlights the response of modern poultry to dietary oxidized oil on growth performance, nutrients digestibility, gut health, carcass characteristics, meat quality, blood chemistry and tissue oxidative status. Literature shows that in moderately (peroxide value (PV): 20 to 50 meq kg ⁻¹ ) and highly (PV: 50 to 100 meq kg ⁻¹ or above) oxidized oils, lipid peroxidation causes rancid odours and flavours that negatively affect feed palatability, reduces intestinal villus height that decreases the surface area available for nutrients absorption. The oxidation products also damage fat soluble vitamins (A, D, E and K) in blood resulting in an oxidative stress. The use of oxidized oil in poultry diets has no significant effect on dressing percentage, pH and meat colour, whereas carcass weight decreases and drip loss of meat increases. Overall, there is a contradictory data regarding the influence of oxidized oil in poultry feed depending on the PV and inclusion levels. The reviewed literature shows that the use of mildly oxidized (PV < 20 meq kg ⁻¹ ) oil in poultry feed with 4 to 5% inclusion level decreases the feed cost and ultimately cost of poultry production without compromising their growth performance. It can, therefore, partially replace fresh oil as an efficient, cost effective and sustainable energy source in poultry diets.
The objective of this study was to determine the effect of oxidized fish oils on growth performance, metabolic oxidative status, and intestinal barrier function in broiler chickens. A total of 240 1-d-old female broiler chickens were assigned to 4 dietary treatments. Dietary treatments comprised of a basal diet supplemented with 4% of non-oxidized (fresh) fish oil, low-oxidized fish oil (FLX), moderately oxidized fish oil (FMX), and highly oxidized fish oil (FHX). Serum corticosterone levels at day 14 and liver concentrations of malondialdehyde (MDA) at day 14 and 21 were higher in birds fed oxidized fish oil compared with those fed then non-oxidized fish oil diet (P < 0.01 in both cases). Furthermore, mRNA expression levels of claudin-1 and occludin were reduced, while those of IL-22 and catalase were increased, in the livers of birds fed the highly oxidized oils compared with those fed fresh fish oils (P ≤ 0.001 in all cases). These results indicate that supplementation of broiler diets with 4% oxidized fish oils can cause lipid peroxidation in the liver, involving increased concentrations of MDA, impaired gut barrier function as a result of increased intestinal permeability due to decreased expression of the tight junction proteins claudin-1/occludin, and intestinal inflammation mediated via upregulation of IL-22 expression in the mucosal tissues.
