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Amorphous lead metaborate (Pb(BO 2 ) 2 H 2 O) nanostructures were synthesized by a simpl and cost-effective synthesis method which is based on precipitation of lead ions using boric acid/sodium hydroxide buffer (pH 9.2) in the presence of polyethylene glycol (PEG). Scanning electron microscopy images showed that the average particle size is 30±9 nm...
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... 913 cm −1 are the asymmetric and symmetric stretching of [BO 3 ], respectively. The band at 685 cm −1 is assigned to out-of-plane bending of [BO 3 ]. These assignments are consistent with the structure of Pb(BO 2 ) 2 ·H 2 O, in which the polyborate anion contains only [BO 3 ] functional group. The DTG/TG curve of the Pb(BO 2 ) 2 ·H 2 O product (Fig. 4) indicates three mass losses. First mass loss of 6.17 % appears from 303 K to 493 K, which corresponds to the loss of one water molecule and agrees with the calculated value of 5.80 %. Second mass loss is 2.56 % from 493 K to 693 K, which displays PEG decomposition [27]. Third mass loss in the DTG curve is at 785 K due to the ...
Citations
... The Synthesis of Lead Borate Nanoparticles (LB-Np) Amorphous LB-Np were prepared using a simple bufferprecipitation method. Their structural and morphological characterizations were done, and properties were explained in the previous study [16]. Briefly, sodium hydroxide and boric acid were mixed with each other (stoichiometric ratio 1:2) in 60 mL of distilled water. ...
Cancer is a complex and multistage disease that causes suffering worldwide. Several mutations in tumor suppressor proteins are mostly responsible for tumorigenic development. Thus, determination of the mutations and developing a mutation targeted therapy are crucial in order to cure cancer. Moreover, since healthy cells do not have mutations in their tumor suppressor genes, mutation-specific treatment is responsible for selective treatment without harming a healthy tissue in the body. In this current study, lead borate nanoparticles (LB-Np) have been synthesized, and their effects on P53 mutant cancer cells were investigated. The synthesis method includes steps of mixing a borate buffer solution with the lead nitrate solution, washing the resulting precipitate with distilled water and eventually preparing stable LB-Np solutions. Cell viability analysis was conducted to identify the toxicity of LB-Np in HaCaT, A549, MCF7, and T47D cell lines. The changes in morphologies of breast cancer cell lines were demonstrated by using microscopical analysis. Additionally, alterations in gene expressions were determined in breast cancer cell lines after LB-Np treatment. This multidisciplinary study also identified the selective effect of LB-Np in cancer cell lines, in vitro. MTS and quantitative polymerase chain reaction assays demonstrated the effect of LB-Np were specific for p53 mutation cell line, T47D. Breast cancer cell line T47D has 580 C/T mutation which affects the activation of p53 tumor suppressor protein. However, LB-Np treatment effectively killed T47D cell lines and did not affect any other cell lines that have no p53 mutations such as MCF7, A549, and healthy HaCaT. Overall, synthesized LB-Np were found to be effective in p53-mutated cell lines and showed a remarkable selective anti-cancer activity.
In the present work, lead metaborate nanoparticles (55 ± 10 nm) as a novel type of nano-fillers was used in order to increase the ballistic performance of aramid fabrics. The nanoparticles were synthesized by co-precipitation method and their dispersions were prepared with various polyethylene glycol (PEG) molecules and then were impregnated on Twaron® aramid fabrics. The ballistic panels were produced by a vacuum assisted resin transfer method using an epoxy system with treated and neat aramid fabrics. The ballistic impact resistance of the Twaron®/epoxy panels was determined according to the NIJ-STD-0108.01 standard. All panels were tested against 9 mm FMJ bullets with an impact speed of 390–400 m/s for armor application. The influence of the lead metaborates and/or silica as nano fillers on the energy dissipation capability and impact resistance of aramid fabrics was examined. It was observed that the samples impregnated with lead metaborate showed higher ballistic absorbed energy values than neat samples. The effect of lead metaborate on the energy absorption capacity of aramid/epoxy plates depends on PEG/nanoparticle mol ratio. Test results revealed that the aramid/epoxy laminates treated with dual phase containing nanosized lead metaborate and silica had high ballistic energy absorption values.
