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Context:
Fine-needle aspiration (FNA) is increasing in popularity as a means of diagnosing mass lesions in retroperitoneal area. With use of radiologic guidance for needle placement, this technique is an effective way to obtain diagnostic material.
Aims:
The aims of the study were (1) to establish the validity and reliability of fine needle aspi...
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Histochemical studies on the mandibular condyle of the human fetus at gestational ages 12, 14, and 16 weeks were performed. Methods. Histological sections were stained with Schiff’s periodic reaction for glicoproteins, hematoxiline eosine detects mesenchymal tissue and trichhromic stain for collagen. The ANOVA one-way test was used to evaluate the...
Background:
The role of tumour inflammation and the dysplastic epithelial-stromal interactions on the nature of collagen fibres in the extracellular matrix of dysplastic epithelium is not fully understood. The present study was aimed to evaluate and compare the inflammation and pathological stromal collagen (loosely packed thin disorganized collag...
Citations
... USG abdomen, CECT abdomen is usually diagnostic. Aspiration cytology has been reported in some studies [8]. Alphafetoprotein (AFP) (preoperative and during postoperative follow up) is done in all cases. ...
Introduction: In pediatric surgical practice, teratomas in gonads and sacrococcygeal areas are relatively common neoplasms. Teratomas in extragonadal sites are rare, with diverse clinical features and variable biological behavior. Aim: The aim of the study was to observe the prevalence of pediatric teratomas in atypical sites, clinical presentation, and histological variation. Materials and Methods: This prospective observational study was carried out for 5 years from January 2017 to December 2022 in the Department of Pathology in a tertiary care hospital in collaboration with Department of Pediatric Surgery. 119 cases of pediatric teratoma were analyzed in the Department of Pathology of which 42 cases were at atypical sites. Clinical parameters like history taking and relevant clinical examination, imaging studies and routine investigations were all done according to the proforma. The excised specimens were received. Sections from various areas of the tumor was submitted. The paraffin embedded tissue blocks were subsequently stained for H&E followed by histopathological reporting. Results and Analysis: A total of 119 cases of pediatric teratomas were recorded, of which, 42 cases were teratoma of atypical site. This included, retroperitoneal teratoma (14 cases), sacrococcygeal teratoma (13 cases), gastric teratoma (3 cases), cervical teratoma (1 case), pulmonary teratoma (1 case), adrenal teratoma (2 cases), floor of the mouth (1 case), pancreas (1 case), 37 kidney (2 cases), abdominal wall (1 case), oral cavity (2 cases) and mesentery (1 case). Retroperitoneum and sacrococcyx were the commonest rare sites. Conclusion: Meticulous search for the immature or malignant component should be instituted as it helps in therapeutic decisions. Early diagnosis influences clinical decision and management, providing a better outcome. Continued follow-up (with alpha-fetoprotein and radiology) to rule out recurrence. More effective antenatal screening, for early diagnosis and management, to reduce the risk of malignant transformation, hence better prognosis.
... USG abdomen, CECT abdomen is usually diagnostic. Aspiration cytology has been reported in some studies [7]. Alpha-fetoprotein (AFP) (preoperative and during postoperative followup) is done in all cases. ...
Background: Extra-gonadal teratomas are rare tumors in Pediatric surgical practice. We studied the teratomas of atypical sites attended in our tertiary care center. Aim: Aim of the study was to find out the incidence of pediatric teratomas in atypical sites, clinical presentation and histological variation. Material and Methods: Over 15 years (January 2005 to December 2020), 29 cases of pediatric teratomas in atypical sites were studied. These sites included neck (number-one), retroperitoneum (number-fourteen), adrenal gland (number-two), renal (number-two), gastric(number-three), pancreas (number-one), pulmonary (number-one), floor of the mouth(number-one), oral (number-two), abdominal wall (numberone) and the mesentery (number-one). Patients were treated in the Department of Pediatric Surgery and specimens were reviewed in the Department of Pathology. Age, sex, clinical presentation, investigations (all patients had complete blood examination and alpha-fetoprotein) and imaging (USG of the local part and CECT as guided by the organ of involvement). Results: 29 pediatric teratomas in uncommon sites were reviewed. Out of 14 cases of retroperitoneal teratoma, three were immature. Cervical teratoma in a neonate was mature. Three cases of gastric teratomas were reported as mature. Two cases of adrenal teratomas also showed the histological features of mature teratoma. Renal teratomas (two) were benign. One each of pulmonary teratoma, pancreas and floor of the mouth were reported as mature. Two patients presented with oral teratoma were reported as mature teratomas. One patient had teratoma arising from the abdominal wall and was resected completely (mature teratoma). Teratoma arising from the mesentery also underwent complete resection. Conclusion: A small percentage of Pediatric teratomas occur in atypical sites. In our series, retroperitoneal tumors were predominant. Early surgical excision is the treatment of choice. Malignant change is known to occur in Pediatric teratoma and the patients need long term follow-up.
... such as needle core biopsy (NCB) or fine needle aspiration biopsy (FNAB), guided using ultrasonography (US) or computed tomography (CT), offer the possibility of obtaining a correct diagnosis, differentiating between benign and malignant tumors and also between metastatic and primary tumors, as well as establishing the tumor subtype. This allows the physician to establish the most appropriate therapeutical management: radiotherapy or chemotherapy, with or without surgery (3). ...
Minimally invasive biopsy procedures have proven over the years to be essential for obtaining a correct diagnosis of retroperitoneal tumors,
The retroperitoneal space is a potential space extending from lumbar to the pelvic region, behind the peritoneum. It encloses many vital organs like adrenals, kidneys, ureters, pancreas, aorta and its branches, inferior vena cava and its tributaries and many lymph nodes along with loose connective tissue and fat. The literature regarding role of fine needle aspiration cytology (FNAC) for diagnosis of retroperitoneal lesions as a whole, is exceedingly limited. The present study was conducted to elucidate the spectrum of retroperitoneal lesions and to determine the diagnostic accuracy of fine needle aspiration cytology, presenting to a tertiary care referral centre. A total of 389 aspirates from retroperitoneal lesions were reviewed for clinical and radiological details. The smears were studied for the cytological diagnosis. Cytological-histological correlation was assessed and the causes for discordant diagnoses were determined. The patients' age ranged from 1 to 88 years. There were 234 (60.2%) males and 155 (39.8%) females. In 61 (15.7%) aspirations, the yield was inadequate for reporting and 328 were satisfactory. About 113 (29.0%) aspirates were from pancreatic masses alone, 97 (24.9%) from the retroperitoneal lymph nodes, 70 (17.9%) from the kidneys, 45 (11.5%) from the adrenals, 41 (10.5%) from the retroperitoneal soft tissues and 23 (5.9%) from retroperitoneal segments of the gut. There were 249 (64.0%) neoplastic lesions and 79 (20.3%) non-neoplastic lesions, the ratio being 3.1:1. Eight (2.0%) aspirates were reported as suspicious for malignancy, and 5 (1.2%) aspirates were reported as neoplastic but could not be categorized as benign or malignant. Of the neoplastic lesions, malignant neoplasms (n = 216; 87.1%) were much more common than the benign (n = 20; 8.0%), the ratio being 10.8:1. Of all the satisfactory aspirates, subsequent histopathology was available only in 33/327 (10%) cases. A positive correlation between cytological and histological diagnosis was observed in 27/33 (81.8%) cases. We believe FNAC is a useful method for an early, rapid, minimally invasive and reliable pre-operative diagnosis for retroperitoneal lesions and can often obviate the need for open surgical biopsy.
