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Creatinine phosphokinase levels
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Context: Fusion of lumbar spine is one of the standards of care for various pathologies such as lumbar canal stenosis and spondylolisthesis. Transforaminal lumbar interbody fusion (TLIF) achieves the necessary goals but with greater muscular trauma due to denervation and loss of muscle mass which may result in poor short-term outcomes. Minimally in...
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Context 1
... serum creatine phosphokinase (CPK) levels were also measured on third postoperatively day in the patients of the two procedural groups. It was found that the MIS-TLIF group showed lower levels (16.56 ± 4.41 u/L) which was statistically significant as compared to the O-TLIF group (24.52 ± 7.2 u/L) [ Figure 1]. ...
Context 2
... serum creatine phosphokinase (CPK) levels were also measured on third postoperatively day in the patients of the two procedural groups. It was found that the MIS-TLIF group showed lower levels (16.56 ± 4.41 u/L) which was statistically significant as compared to the O-TLIF group (24.52 ± 7.2 u/L) [ Figure 1]. ...
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... The increase in disc height from 8 mm to 12 mm and foraminal height from 15 mm to 22 mm, both with P-values of <0.001, are indicative of the efficacy of the surgical procedure in restoring spinal anatomy. These improvements are comparable to those reported in a 2022 study, where postoperative radiological parameters significantly improved following lumbar spondylolisthesis surgery [18]. In the present study, the average operative time of 147.5 minutes and blood loss of 382.7 mL are within the ranges reported in the literature, suggesting a standard level of complexity and risk associated with these procedures [19]. ...
Introduction: Lumbar spondylolisthesis, a condition characterized by the displacement of one vertebra over another, often leads to chronic back pain and functional impairment. Posterior decompression and TLIF are used as surgical options for patients with lumbar spondylolisthesis. Aim of the Study: The aim of this study was to assess the clinical & radiological outcomes of posterior decompression & transforaminal lumbar interbody fusion (TLIF) among patients with lumbar spondylolisthesis. Methods: This prospective observational study was carried out at NITOR, Dhaka, Bangladesh, during the period from January 2020 to December 2021. Total 30 patients with degenerative lumbar spondylolisthesis were included in this study. Result: In this study, majority of participants were aged 41-50 (47%), predominantly female (60%). Clinical outcomes showed significant improvements post-treatment: low back pain and leg pain, measured by VAS, decreased substantially, and disability scores (ODI and Roland-Morris) also improved markedly. Quality of life, assessed by SF-36, showed notable enhancements in both physical and mental scores. Radiologically, there were significant improvements in disc and foraminal height, reduction in spondylolisthesis severity, and restoration of lumbar lordosis and spinal stability. The average surgery time was around 147.5 minutes, with a mean blood loss of 382.7 mL and an average hospital stay of 7.1 days. A 90% fusion rate was achieved at 1-year follow-up, with dural tears being the most common complication. Despite some complications, the majority of surgeries were completed safely. Conclusion: Posterior decompression and TLIF appear to be effective in treating lumbar spondylolisthesis, as evidenced by improved clinical and radiological outcomes.
... A total of 15 studies were finally included for data extraction and analysis. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The detailed search methodology is summarized in Figure 1 (PRISMA flowchart). The study design, demographics, and features of the included studies are summarized in Table 1. ...
... [5] Balasubramanium et al. reported it to be 33 ± 12 shots per case. [12] Other studies also concluded increased radiation exposure with minimally invasive techniques. [32,33] The cost of treatment is a major factor in deciding the surgical approach/technique. ...
Objective: The global shift of trends to minimally invasive spine (MIS) surgery for lumbar degenerative diseases has become prominent in India for few decades. We aimed to assess the current status of MIS techniques for lumbar interbody fusion and their surgical outcomes in the Indian population.
Materials and Methods: A systematic review (following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines) was performed using PubMed and Google Scholar till November 2020. The primary (visual analog scale [VAS] and oswestry disability index [ODI] scores; intraoperative blood loss; duration of surgery; duration of hospital stay, and fusion rate) and secondary (wound-associated complications and dural tear/cerebrospinal fluid (CSF) leak) outcomes were analyzed using Review Manager 5.4 software.
Results: A total of 15 studies comprising a total of 1318 patients were included for analysis. The pooled mean of follow-up duration was 26.64 ± 8.43 months (range 5.7–36.5 months). Degenerative spondylolisthesis of Myerding grade I/II was the most common indication, followed by lytic listhesis, herniated prolapsed disc, and lumbar canal stenosis. The calculated pooled standard mean difference (SMD) suggested a significant decrease in postoperative ODI scores (SMD = 5.53, 95% confidence interval [CI] = 3.77–7.29; P < 0.01) and VAS scores (SMD = 6.50, 95% CI = 4.6–8.4; P < 0.01). The pooled mean blood loss, duration of postoperative hospital stay, duration of surgery, and fusion rate were 127.75 ± 52.79 mL, 4.78 ± 3.88 days, 178.59 ± 38.69 min, and 97.53% ± 2.69%, respectively. A total of 334 adverse events were recorded in 1318 patients, giving a complication rate of 25.34%.
Conclusions: Minimally invasive transforaminal lumbar interbody fusion (TLIF) is the most common minimally invasive technique employed for lumbar interbody fusion in India, while oblique lumbar interbody fusion is in the initial stages. The surgical and outcome-related factors improved significantly after MIS LIF in the Indian population.
... However, open approaches are associated with significant soft-tissue morbidity. 4 Minimally invasive spine surgery (MIS) has attracted increasing attention in the past few years. 4 The first description of MIS-TLIF appeared in the literature in 2003, and since that time, use of this technique has been gaining popularity. ...
... 4 Minimally invasive spine surgery (MIS) has attracted increasing attention in the past few years. 4 The first description of MIS-TLIF appeared in the literature in 2003, and since that time, use of this technique has been gaining popularity. 5 Proponents of MIS fusion suggest that it is associated with reduced blood loss, short hospital stay and lesser postoperative pain. ...
Study design:
Prospective, observational.
Objectives:
The aim of our study was to assess the amount of reduction in lean muscle mass (LMM) of multifidus muscle (MFM) between conventional open Transforaminal lumbar interbody fusion (CO-TLIF) as compared to Minimally invasive spine Transforaminal lumbar interbody fusion (MIS-TLIF).
Methods:
This study was conducted between 2017 and 2020. It included 100 patients divided into two groups, 50 patients treated with CO-TLIF, 50 treated with MIS-TLIF. Only patients undergoing single level, primary lumbar fusion at L4-5 or L5-S1 level for degenerative pathologies were included. All patients were assessed by magnetic resonance imaging (MRI) scans 1-year post surgery. Measurements were performed using ImageJ image processing program.
Results:
Mean percentage reduction in LMM in CO-TLIF group was 45.52 ± 12.36% and MIS-TLIF group was 25.83 ± 9.64% [statistically significant (t = 8.78, P < .001)]. Mean percentage reduction in LMM on side of cage insertion was 39.63 ± 15.96% and opposite side was 31.40 ± 15.01% [statistically significant (t = 9.06, P < .001)]. Mean reduction of LMM among males was 29.38 ± 15.23% and females was 40.42 ± 12.67% [statistically significant (t = -3.95, P < .001)].We observed significant but weak degree of correlation between age and percentage reduction of LMM (r = .22, P = .028).
Conclusion:
Mean reduction in LMM was greater in CO-TLIF group as compared to MIS-TLIF. There was greater reduction in LMM in females and on side of cage insertion. We also found greater reduction in LMM with increasing age in both groups.
Objective: To compare the clinical, radiological and functional outcomes of patients between open TLIF and minimally invasive TLIF techniques. Study Design: Prospective cohort study Place and duration: Study was conducted at department of neurosurgery Bakhtawar Amin Hospital, Multan from August 2021 to July 2022 in duration of one year. Methodology: A total of 94 patients planned for transforaminal lumbar interbody fusion (TLIF) were enrolled in study. Main variables of study were intra operative blood loss, duration of surgery, VAS score, ODI index and functional score. SPSS version 24 was used for data analysis, t-test and chi square test were applied to see association among variables. P value less than or equal 0.05 was considered as significant. Results: Oswestry disability index readings were 35.16±2.18 and 5.12±0.61 in O-TLIF and MIS-TLIF groups respectively at 3 weeks after surgery. The differences were statistically insignificant, (p>0.050). Physical component summary of both the groups at different time intervals as shown better outcomes in MIS-TLIF group, no difference was found to be statistically significant except at 6 week. Mental component summary in both the groups was almost equal, (p>0.050). Implications: There was no local study on comparison of open and minimally invasive technique for TLIF, our study will fulfill the local reference gap and help the surgeons for choice of better management technique in future. Conclusion: Minimally invasive surgery TLIF technique is better in immediate benefits as soft tissue injury and iatrogenic injury which is associated with better post operative pain functional recovery time. So, minimal invasive interbody fusion is a safe and reliable option for short term (blood loss, post operative pain) and long term outcomes like functional recovery. Keywords: Interbody fusion, VAS score, SF-36, ODI index, TLIF Technique
