Figure - available from: Frontiers in Psychiatry
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Correlational analysis of H3K9me2 promoter occupation and mRNA expression. Scatterplots showing correlations between H3K9me2 promoter DiffReps reads and mRNA levels of the corresponding gene. (A) Promoter loci where H3K9me2 occupancy is significantly increased in SCZ compared to NPC. Promoters GPHN, CDHR2, GPX6, and OXT show H3K9me2 diffReps reads have significant negative correlation with their corresponding mRNA levels. (B) Promoter loci where H3K9me2 occupancy is significantly decreased in SCZ compared to NPC. Promoters AKT3, CDH20, and C4B show H3K9me2 diffReps reads have significant negative correlation with their corresponding mRNA levels. Pearson’s r and P-values for each loci are shown in the insert table.
Source publication
The existence of repressive and durable chromatin assemblies along gene promoters or networks, especially in the brain, is of theoretical and therapeutic relevance in a subset of individuals diagnosed with schizophrenia who experience a chronic, persistent, and treatment-resistant trajectory. We used chromatin immunoprecipitation followed by deep s...
