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Correlation of atopy and HRCT scores. The atopy scores of the nonatopic subjects were accepted as zero. r = 0.54 and p < 0.001.
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Bronchiectasis is common in developing countries, but its precise underlying mechanism can be detected in only about 40% of the cases. The studies reporting the frequency of atopy and its relation to radiological findings and lung function in bronchiectasis are limited in number, and the results are controversial. The present study was designed to...
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Background: Chronic lung diseases such as bronchiectasis (BR) can adversely affect health-related quality of life (HRQOL), but there are limited studies conducted to investigate HRQOL in elderly BR patients. This study aims to investigate the HRQOL in elderly patients with BR and to assess its relationship with clinical outcomes and radiological fi...
Background:
The prevalence of non-cystic fibrosis (CF) bronchiectasis is increasing in both developed and developing countries in recent years. Although the main features remain similar, etiologies seem to change. Our aim was to evaluate the clinical and laboratory characteristics of our recent non-CF bronchiectasis patients and to compare these w...
Background/aims:
Bronchiectasis is aggravated by gastroesophageal reflux disease (GERD) owing to micro aspiration. Some researchers note the effect of antireflux surgery in bronchiectasis with GERD. However, few have investigated the effects of medical antireflux therapy. We investigated the effect of proton pump inhibitors (PPIs) in bronchiectasi...
Citations
... Since then, some studies have reported a direct link between bronchiectasis and bronchial hyperreactivity or atopy. [29,30] In our study, however, we did not identify a positive relationship between bronchiectasis and atopy. In addition, the higher level of serum eosinophils we observed in patients with coexistent bronchiectasis suggests that the presence of bronchiectasis could potentially be used to identify a phenotype of patients with severe eosinophilic asthma (SEA). ...
Background:
This meta-analysis aimed to systematically estimate the prevalence of comorbid bronchiectasis in patients with asthma and to summarize its clinical impact.
Methods:
Embase, PubMed, and Cochrane Library electronic databases were searched to identify relevant studies published from inception until March 2020.
Study selection:
Studies were included if bronchiectasis was identified by high-resolution computed tomography. Outcomes included the prevalence of bronchiectasis and its association with demographic characteristics and indicators of asthma severity, including results of lung function tests and the number of exacerbations.
Results:
Five observational studies with 839 patients were included. Overall, the mean prevalence of bronchiectasis in patients with asthma was 36.6% (307/839). Patients with comorbid bronchiectasis had lower forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) (MD: -2.71; 95% CI: -3.72 to -1.69) and more frequent exacerbations (MD: 0.68; 95% CI: 0.03 to 1.33) than those with asthma alone, and there was no significant difference of sex, duration of asthma and serum levels of immunoglobulin(Ig)Es between asthmatic patients with or without bronchiectasis.
Conclusion:
The presence of bronchiectasis in patients with asthma was associated with greater asthma severity. There are important therapeutic implications of identifying bronchiectasis in asthmatic patients.
... Sol ventriküler fonksiyonlardaki bozulma ise sadece sağ ventrikül fonksiyonu ile ilşikili bulunmuştur. GATA Ankara Hastanesi Allerjik Hastalıklar Kliniğinde bronşektazi hastalarında atopi ve bronşektazi ilişkisi araştırılmış ve bronşektazi olgularında atopi sıklığı %48.8, kontrol olgularda ise %11.8 olarak bulunmuştur(82). Yine ortalama atopi skoru sıra ile 14.3 ± 10.1 mm ve 5.5 ± 2.1 mm) olarak anlamlı yüksek bulunmuştur. ...
In this review, we aimed to determine the etiopathogenesis, diagnosis and treatment of non-cystic fibrosis bronchiectasis in the light of scientific studies conducted in our country. For this purpose, Pubmed, Web of Science ve Ulakbim TR Dizin were searched and the publications available as of July 2019 were evaluated and the findings of these studies were summarized and presented.
... Nine (25%) patients had positive SPT results with BR (4). Ozturk et al. reported that atopy was more frequent in patients with BR (48%) compared with healthy subjects (5). ...
... In total, 30.4% of BR patients were atopic (16). Except for Ozturk et al. 's research, most of the previous studies used different methodologies from our study, which used bronchography for the diagnosis of BR and had small sample sizes (5,15,16). In recent Turkish studies, the atopy rate was reported as 14.6%-25% in the general population (18,19). ...
Background/aim:
Non-cystic fibrosis bronchiectasis (non-CF BR) is common in developing countries.Limited data are available regarding the impact of atopy, and no data are available regarding allergic rhinitis in patients with adult bronchiectasis.The aim of this study was to evaluate the prevalence of atopy and allergic rhinitis in the clinical conditions of patients with BR.
Materials and methods:
The study enrolled 101 patients who were diagnosed with non-CF BR using high-resolution computed chest tomography. Allergic rhinitis (AR) was defined by skin prick test (SPT) positivity and the presence of any nasal symptoms (watery runny nose, nasal obstruction, nasal itching, and sneezing).
Results:
The mean age of patients was 48 ± 15 years (range 18–82); 55 (54.5%) patients were female. SPT positivity was detected in 37 (36.6%) cases. AR was detected in 32 (31.7%) patients with non-CF BR. AR was related to dyspnea (P = 0.04) and number of admissions to an emergency department in the previous year (P = 0.01). Forced expiratory volume in 1 s and forced vital capacity in patients with and without AR were different (P = 0.01 and P = 0.01, respectively). AR was correlated with number of admissions to an emergency department in the last year (r = 0.417, P = 0.005).
Conclusion:
We concluded that atopy was detected in more than one-third of adult non-CF BR patients. This study demonstrated that non-CF BR patients might have AR; it might be important to be aware of nasal symptoms in non-CF BR patients.
... Based on prior findings from our group and others, we sought to comprehensively assess sensitization levels to multiple specific allergens in the CAMEB cohort (10,(17)(18)(19)(20). Measured specific IgE (sIgE) titers against house dust mite (HDM), Alternaria alternata (Alt a), and recombinant allergens of Aspergillus fumigatus (rAsp) revealed high frequencies of sensitization in patients with bronchiectasis ( Figure 1). ...
Rationale:
Allergic sensitization is associated with poor clinical outcomes in asthma, chronic obstructive pulmonary disease and cystic fibrosis however its presence, frequency and clinical significance in non-CF bronchiectasis remain unclear.
Objective:
To determine the frequency and geographic variability that exists in sensitization pattern to common and specific allergens including house dust mite and fungi and, to correlate such patterns to airway immune-inflammatory status and clinical outcomes in bronchiectasis.
Methods:
Patients with bronchiectasis were recruited in Asia (Singapore & Malaysia) and the United Kingdom (Scotland) (n=238) forming the Cohort of Asian and Matched European Bronchiectasis (CAMEB) which matched recruited patients on age, gender and bronchiectasis severity. Specific-IgE response against a range of common allergens was determined, combined with airway immune-inflammatory status and correlated to clinical outcomes. Clinically relevant patient clusters based on sensitization pattern and airway immune profiles ("immuno-allertypes") were determined.
Measurements and main results:
A high frequency of sensitization to multiple allergens was detected in bronchiectasis, exceeding that in a comparator cohort with allergic rhinitis (n=149). Sensitization associated with poor clinical outcomes including decreased pulmonary function and more severe disease. 'Sensitized-bronchiectasis' was classified into two 'immuno-allertypes': one fungal-driven and pro-inflammatory versus house dust mite-driven, chemokine-dominant with the former demonstrating poorer clinical outcome.
Conclusion:
Allergic sensitization occurs at high frequency in bronchiectasis patients recruited from different global centres. Improving endo-phenotyping of 'sensitized-bronchiectasis', a clinically significant state, and 'treatable trait' permits therapeutic intervention in appropriate patients and may allow improved stratification in future bronchiectasis research and clinical trials.
... Based on prior findings from our group and others, we sought to comprehensively assess sensitization levels to multiple specific allergens in the CAMEB cohort (10,(17)(18)(19)(20). ...
... Bronşektazili hastalardaki atopi sıklığı %10-54 arasında değişmektedir (20). Çalışmamızda 4 (%11.4) ...
Aim: To evaluate the clinical characteristics of patients with bronchiectasis, localization, pulmonary function tests, the etiologic factors and investigation of the relationship between localization- pulmonary function tests and etiology in our Pediatric Allergy-Immunology Clinic. Materials and Methods: We retrospectively evaluated the clinical, radiologic, and physiologic findings of 35 patients with non cystic fibrosis- bronchiectasis confirmed by high-resolution computed tomography. Results: The mean age was 11.6 ± 3.3 (4.8-18) years, and 20 of them were males (57%). The age at onset of symptoms was 6.8 ± 3.8 (1-15) years, while the age of diagnosis was 10.4 ± 3.1 (4.2-15.8) years. The most common symptoms were cough (100%), sputum (54.3%) and wheezing (54.3%), respectively. Crepitant rale was the most frequent physical examination finding (45.7%). In evaluation of chest X-Ray findings; 8 (22.9%) of the patients had bronchiectasis and the most common finding was infiltration (12 (34.3%). Four of the (11.4%) patients had positive skin prick test. The most common involvements on HRCT were left lower lobe in 22 (62.8%), right lower lobe in 21 (60%), right middle lobe in 16 (45.7%). The causes of the bronchiectasis were found to be as postinfectious in 12 patients (34.3%), asthma 7 (20%), immun deficiency 5 (14.3%), and primary ciliary dyskinesia 4 (11.4%). There was not an aetiological cause in 7 (20%) of the patients. Conclusion: Infections in our country still maintain their importance in the etiology of bronchiectasis. Asthma with increasing frequency is another important factor in the development of bronchiectasis. Bronchiectasis should be investigated especially in patients with asthma who has ongoing complaints despite suitable treatment and/or those who has atypical symptoms for asthma despite normal chest radiography. Keywords: Bronchiectasis, childhood, asthma
... 1 Recurrent bacterial, viral and parasitic infections may be likely to induce atopy and hypersensitivity as suggested previously. 20 To our knowledge, this study has demonstrated the association of atopy and RVV with undetermined etiology for the first time in the published literature, as patients with recurrent vaginal candidiasis were mostly included in other studies dealing with the issue. [3][4][5][6] Although SPT is a valuable and useful diagnostic tool to document atopy in daily medical practice, we must admit that lack of vaginal provocation test during an asymptomatic period, determination of total and specific IgE levels and eosinophil count in blood and vaginal smears as limitations of our study. ...
Recent findings show that the vaginal mucosa can develop an allergic response to environmental allergens and there is a strong association between atopy and some recurrent vulvovaginal infections. In this study, we investigated prospectively the rate of atopy in patients with recurrent vulvovaginitis of undetermined etiology (RVV).
After being investigated by a gynecologist, 35 patients with RVV who were considered as undetermined etiology formed the study group. The control group consisted of 150 healthy females. Study and control groups were investigated for atopy by means of skin prick test for common aeroallergens. Associated allergic disease and familial atopy history of the subjects were recorded.
The rate of atopy (11/35; 31.4% vs 9/150; 6%) was significantly higher (P < 0.001) in the study group than in the controls. Familial history of atopy was significantly more frequent in the study group than in the controls (10/35; 28.6% vs 8/150; 5.3%, P < 0.05). RVV in atopics is more associated with seasonal rhinitis than in nonatopics (5/11; 45.4% vs 2/24; 8.3%, P < 0.05).
We concluded that a significant number of RVV is associated with atopy. Although the exact mechanism(s) of this relationship remains to be investigated atopy might be a causative and/or contributing factor in the pathogenesis of RVV.
Background:
Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease due to Aspergillus fumigatus (Af) which occurs in 10% of patients with cystic fibrosis (CF). ABPA is associated with increased morbidity and accelerated lung function decline; however, existing diagnostic criteria are nonspecific and diagnosis remains challenging. As ABPA is driven by Th2 inflammation, the aim of this study was to evaluate exhaled nitric oxide (FE NO ), eosinophilic cationic protein (ECP), peripheral eosinophil count, and bronchodilator response (BDR) in patients with CF.
Methods:
A prospective observational cohort study of pediatric CF patients in a tertiary center. Patients had a clinical and serologic ABPA assessment, FENO , serum ECP, peripheral eosinophil count, and assessment of BDR. Patients were stratified into three groups; ABPA, Af sensitized (AFS), and non-ABPA non-Af-sensitized (non-AFS).
Results:
A total of 62 patients were included in the study: 13% ABPA, 19% AFS, and 68% non-AFS. Mean FENO was higher in the ABPA group at 37.8 ppb compared to AFS 15.1 ppb (P = .05) and non-AFS 13.7 ppb (P = .04). Mean peripheral eosinophil count in ABPA group was also higher at 1000 cells/uL, compared to AFS 221 cells/uL (P = .03) and non-AFS 220 cells/uL (P = .03). Mean BDR in ABPA group was 13% compared to 5.5% in non-AFS (P = .01). Serum ECP was higher in patients with ABPA positive compared to the other groups, although this was not statistically significant.
Conclusion:
In children with cystic fibrosis, FENO and peripheral eosinophil counts are elevated in ABPA compared to those that are just sensitized to Aspergillus and may serve as useful diagnostic tests.
Objective: To assess the efficacy of bronchodilators in the treatment of bronchiectasis. Methods: Forty-three patients with bronchiectasis were involved in the study. Each patient inhaled 400 g salbutamol via metered dose inhaler at the first day and inhaled 5 mg salbutamol via nebulizer the next day, and the lung function was tested 30 min after inhalation. The same procedures were done respectively at 3 d and 4 d with ipratropium bromide 40 g by metered dose inhaler and 500 g by a nebulizer respectively. Results: The results showed significant improvements from the baseline of peak expiratory flow rate (PEF) by 8. 4% and 14. 2%, forced expiratory volume in the 1st second(FEV1) by 7. 5% and 13. 0% and forced vital capacity (FVC) by 8. 9% and 14. 3% after low- and high-dose salbutamol, respectively. The improvements after low- and high-dose ipratropium bromide for PEF, FEV1 and FVC were 7. 3% and 11. 6%, 5. 5% and 8. 2%, 6. 9% and 9.4%, respectively. Eighteen patients(41. 9%)responded to one or both bronchodilators significantly 015% improvement in FEV1). Six patients responded to both, nine to salbutamol alone and another three to ipratropium bromide alone. Skin prick testing against a panel of 14 allergens was done on each subject and 13 cases showed positive results (30. 2%). Conclusion: There are significant bronchodilator responses in some patients with bronchiectasis and patients with bronchiectasis should therefore undergo bronchodilator testing.
