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Objective:
Glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) is a subunit of a ligand-gated ion channel that regulates the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by controlling the release of gonadotropin-releasing hormone. Few studies have investigated the association between the GRIA1 gene and human...
Context in source publication
Context 1
... Pearson correlation analysis showed significant positive correlations between LH and FSH levels (r= 0.504, p< 0.01), LH levels and number of follicles (r= 0.611, p< 0.01), FSH levels and age (r= 0.207, p < 0.05), number of follicles and age (r = 0.192, p = 0.048), and FSH levels and number of follicles (r= 0.438, p< 0.01). However, no significant correlation was found between LH levels and age (r = 0.162, p = 0.107) ( Table 4). These results illustrate the interactions among FSH and LH levels, age, and number of follicles. ...Similar publications
A comparative prospective study was conducted in the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al-Nahrain University, from September 2019 to March 2020. The aim of the study was to evaluate the level of hyaluronic acid (HA) in endometrial fluid at day of trigger in infertile women whom undergoing ovarian stimul...
Citations
... Cushman et al. found the correlation between GRIA1 SNPs and cattle infertility [19]. In addition, Sheikhha et al. also observed the relationship between GRIA1 variants and ovarian response to human menopausal gonadotropin in the group of Iranian women [20]. The above studies show that GRIA1 plays an important role in diseases related to pregnancy in women. ...
Background
Recurrent spontaneous abortion (RSA) is one of the common complication of pregnancy, bringing heavy burden to the patients and their families. The study aimed to explore the lncRNA-miRNA-mRNA network associated with recurrent spontaneous abortion.
Methods
By transcriptome sequencing, we detected differences in lncRNA, miRNA and mRNA expression in villus tissue samples collected from 3 patients with RSA and 3 normal abortion patients. Differentially expressed lncRNAs, miRNAs and genes (DELs, DEMs and DEGs, respectively) were identified, and Geno Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used to determine the functions of DELs and DEGs, which were analysed by Fisher’s test. We also observed the regulatory relationships between miRNA-mRNA and lncRNA-miRNA by Cytoscape 3.6.1.
Results
The results showed that 1008 DELs (523 upregulated and 485 downregulated), 475 DEGs (201 upregulated and 274 downregulated) and 37 DEMs (15 upregulated and 22 downregulated) were identified. And we also constructed a novel lncRNA-related ceRNA network containing 31 lncRNAs, 1 miRNA (hsa-miR-210-5p) and 3 genes (NTNG2, GRIA1 and AQP1).
Conclusions
lncRNA-related ceRNA network containing 31 lncRNAs, 1 miRNA (hsa-miR-210-5p) and 3 mRNAs (NTNG2, GRIA1 and AQP1) was constructed. The results may provide a basic theory for elucidating the mechanism underlying RSA.
