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3. Convergence of Purkinje cells GABAergic output into the deep cerebellar nuclei

3. Convergence of Purkinje cells GABAergic output into the deep cerebellar nuclei

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The cerebellum is thought to coordinate movement by processing sensorimotor information in the cerebellar cortex before relaying its output to other brain structures. Since all information processed by the cerebellar cortex converges on Purkinje cells (PCs), the ability to record the spiking output from identified populations of these cells is cruc...

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The brain’s control of movement is thought to involve coordinated activity between cerebellar Purkinje cells. The results reported here demonstrate that somatic Ca2+ imaging is a faithful reporter of Na+-dependent “simple spike” pauses and enables us to optically record changes in firing rates in populations of Purkinje cells in brain slices and in...