FIGURE 1 - available via license: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Content may be subject to copyright.
Considerations for Clinical Trials of Intermittent Fasting in Cardiovascular Disease
Source publication
Similar publications
Tetralogy of Fallot with pulmonary stenosis has a diverse clinical spectrum with the degree of right ventricular outflow tract obstruction (RVOTO) and size of the branch pulmonary arteries driving clinical management. Optimal surgical management involves consideration of patient clinical status and degree and location (subvalvar, valvar, and suprav...
Background/Objective: Cardiac magnetic resonance (CMR) is the reference method for right ventricular (RV) volume and function analysis, but time-consuming manual segmentation and corrections of imperfect automatic segmentations are needed. This study sought to evaluate the applicability of an echocardiographically established truncated cone–rhomboi...
BACKGROUND
The aim of this study was to determine the association of right ventricular function with in-hospital mortality and mortality 1 year after discharge in patients hospitalized for COVID-19 pneumonia.
METHODS
The study was conducted in Van Yuzuncu Yil University Faculty of Medicine hospital between February 10, 2021 and August 10, 2022. A...
Right ventricular structural and functional changes result from many cardiovascular disorders in cats. Accordingly, echocardiographic evaluation of the size and function of the right ventricle (RV) provides important prognostic information in many conditions affecting the right heart. Therefore, detection of these changes is clinically important an...
Citations
... IF has emerged as a potential strategy for reducing CVD risk factors [9,46,77]. IF promotes metabolic shifts from glucose to fatty acids and ketones, resulting in improved lipid profiles with reductions in total cholesterol, triglycerides, and LDL cholesterol levels [9,77,78]. IF inhibits atherosclerotic plaque development by decreasing inflammatory markers and prevents monocyte adhesion to Cell Biochemistry and Biophysics vascular endothelial cells, limiting atherosclerosis progression [9]. Additionally, IF increases brain-derived neurotrophic factor (BDNF) and leads to a reduction in blood pressure [9,77,78]. ...
... IF inhibits atherosclerotic plaque development by decreasing inflammatory markers and prevents monocyte adhesion to Cell Biochemistry and Biophysics vascular endothelial cells, limiting atherosclerosis progression [9]. Additionally, IF increases brain-derived neurotrophic factor (BDNF) and leads to a reduction in blood pressure [9,77,78]. It aids in obesity and diabetes management by promoting weight loss, enhancing glucose metabolism, and improving insulin sensitivity [9,46]. ...
... Another mechanism involves the circadian rhythm theory, which emphasizes synchronizing eating patterns with circadian clocks to optimize glucose and fat metabolism [77]. In addition, IF also promotes a ketogenic state, leading to lowered blood pressure and reduced fat accumulation [77,78]. These pathways suggest that IF could be a valuable tool in managing CVD risk factors and informing novel dietary recommendations for cardiovascular health maintenance. ...
Obesity is a leading cause of morbidity and mortality globally. While the prevalence of obesity has been increasing, the incidence of its related complications including dyslipidemia and cardiovascular disease (CVD) has also been rising. Recent research has focused on modalities aimed at reducing obesity. Several modalities have been suggested including behavioral and dietary changes, medications, and bariatric surgery. These modalities differ in their effectiveness and invasiveness, with dietary changes gaining more interest due to their minimal risks compared to other modalities. Specifically, intermittent fasting (IF) has been gaining interest in the past decade. IF is characterized by cycles of alternating fasting and eating windows, with several different forms practiced. IF has been shown to reduce weight and alleviate obesity-related complications. Our review of clinical and experimental studies explores the effects of IF on the lipid profile, white adipose tissue (WAT) dynamics, and the gut microbiome. Notably, IF corrects dyslipidemia, reduces WAT accumulation, and decreases inflammation, which reduces CVD and obesity. This comprehensive analysis details the protective metabolic role of IF, advocating for its integration into public health practices.
