Fig 2 - uploaded by Victor Blokhin
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Concentration of monoamines in perfusate during flow incubation of rat brain slices on the fifth postnatal day (P5) and P30, first with Krebs-Ringer buffer (KRB), and then KRB with increased K + content (KRB + K). * P < 0.05, when comparing groups incubated in KRB with increased K + content and KRB. DA, dopamine; NA, norepinephrine; nd, not detected.
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Context 1
... flow-through incubation of sections obtained from rats on P5 and P30 with KRB, dopamine is determined only on P30 (Fig. 2). During the subsequent incubation of the same sections in KRB with an increased K + , dopamine is determined at P5, and its concentration significantly increases in comparison with the control at P30 (common ...
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[This corrects the article DOI: 10.3892/etm.2019.8312.].
Citations
According to the literature, the cerebrospinal fluid (CSF) in the cerebral ventricles contains numerous neuron-derived physiologically active substances that can function as neurohormones and contribute to volume neurotransmission in the periventricular region of the brain. This study was aimed at carrying out a comparative analysis of CSF and the blood levels of monoamines in rats during ontogenesis as an indicator of age-related characteristics of monoamine transport to body fluids and their function as neurohormones in volume neurotransmission in the periventricular region of the brain. We have shown that CSF in the perinatal period and adulthood contains the most functionally significant monoamines: dopamine, noradrenaline, and serotonin. A comparison of the monoamine levels in the CSF and blood of animals of different age groups revealed that CSF contains monoamines of predominantly neuronal (cerebral) origin and almost no monoamines derived from the general circulation. We also established that monoamines are found in the CSF at physiologically active levels that allow them to act as neurohormones in both reversible volume neurotransmission in the adult brain and irreversible regulation of brain development in the perinatal period.
