Table 1 - uploaded by Kenjiro Koga
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The physicochemical properties (pH and osmolarity), ingredients, and impurities containing in compound glycyrrhizin injections (eight items) marketed in China were compared with those in bland-name drug (Stronger Neo-Minophagen C injection). Glycyrrhizin (GZ), glycine (Gly), and l-cysteine (CysH) as the ingredients, moreover, glycyrrhetinic acid (G...
Contexts in source publication
Context 1
... of Basic and Clinical Pharmacy 347 80 40 800 201109031 freeze-drying 80 40 800 PAI GAN NENG 101203 20 40 20 400 110314 20 40 20 400 110708 20 40 20 400 TIAN QING GAN MEI 1107132 10 50 2) 0 0 1107181 10 50 2) 0 0 1108242 10 50 2) 0 0 WEI YI XING 110103D1 freeze-drying 40 20 400 110103D2 freeze-drying 40 20 400 110501A1 freeze-drying 40 20 400 SNMC is a bland-name drug. No.2, 4, 5, 6, 7, and 9 are generic drugs having same ingredients as SNMC. ...
Context 2
... commercial products of compound glycyrrhizin injections are shown in Table 1. The bland-name drug is SNMC (No.1). ...
Context 3
... 3 shows the concentrations of -GZ and -GZ in all products. In product information sheet, TIAN QING GAN MEI (No.8 in Table 1) only indicates that -GZ is contained as the ingredient. The content of -GZ in SNMC was 101.2-102.0% ...
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Glycyrrhizin (GL) and Glycyrrhetic Acid 3-O-mono-β-D-glucuronide (GAMG) are the typical triterpenoid glycosides found in the root of licorice, a popular medicinal plant that exhibits diverse physiological effects and pharmacological manifestations. However, only few reports are available on the glycosylation enzymes involved in the biosynthesis of...
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Background:
Renowned since ancient times for its medical properties, liquorice is nowadays mainly used for flavoring candies or soft drinks. Continuous intake of large amounts of liquorice is a widely known cause of pseudo-hyperaldosteronism leading to hypertension and hypokalemia. These manifestations are usually mild, although in some cases may...
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Citations
Accumulating evidence suggests that compound glycyrrhizin may have beneficial effects on ulcerative colitis by inhibiting inflammation. However, the credibility of the evidence and safety for this practice are unclear. Therefore, we aimed to perform a systematic review and meta-analysis to evaluate the anti-inflammatory activity and safety of compound glycyrrhizin in the treatment of ulcerative colitis. PubMed, Embase, Cochrane Library, Web of Science, Chinese Biomedical Literature, China National Knowledge Infrastructure, Wanfang Database and CQVIP Database were searched for this review. Twenty-three qualified studies involving 2060 participants were included. There was a significant association of compound glycyrrhizin with TNF-α, IL-6, IL-8, IL-10, IL-17, adverse effects rate and recurrence rate. These results supported the anti-inflammatory activity of compound glycyrrhizin. In addition, compound glycyrrhizin can alleviate the adverse effects of conventional drugs (e.g. sulfasalazine), but it can also lead to edema. Further studies are required on the safety of compound glycyrrhizin and its mitigative effects on the adverse effects of conventional drugs.
Background:
Psoriasis vulgaris is a chronic skin condition affecting patients' quality of life. Long-term use of conventional therapy increases risk of unwanted side effects. Compound glycyrrhizin in conjunction with conventional therapy has been used in clinical practice, but the evidence for such practice has not been evaluated systematically.
Objective:
This review aims to evaluate the efficacy and safety of compound glycyrrhizin in combination with conventional therapy for psoriasis vulgaris.
Methods:
PubMed, Excerpta Medica dataBASE (Embase), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine Database (AMED), CiNii, Chinese Biomedical Literature, China National Knowledge Infrastructure, Chinese Scientific Journals Full Text Database and Wanfang Data were searched from their respective inceptions to July 2015. Randomized controlled trials comparing compound glycyrrhizin plus conventional therapy to conventional therapy alone for psoriasis vulgaris were included. Data analysis was performed using Review Manager 5.3.
Results:
Eleven randomized controlled trials were included in this review. Meta-analysis of the 11 randomized controlled trials indicated that the addition of compound glycyrrhizin increased the number of patients achieving Psoriasis Area and Severity Index (PASI) 60 (RR: 1.30 [1.21, 1.40], I(2) = 6%), when compared with conventional therapy alone. Comparable numbers of patients experienced adverse events in the two groups.
Conclusions:
Compound glycyrrhizin in conjunction with conventional therapy enhances clinical response, and compound glycyrrhizin as add-on therapy does not appear to pose any additional risk in the treatment of psoriasis vulgaris. However, the findings should be interpreted with caution of methodological flaws in the included studies. PROSPERO registration number: CRD42015027763.
