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Orange jasmine, Murraya paniculata (Rutaceae), is a plant from India widely used in folk medicine as antinociceptive, antiinflammatory, and antioxidant. Although oral hypoglycemic agents and insulin are the mainstays of treatment of diabetes mellitus (DM), there is a significant demand for new natural products to reduce the development of diabetic...
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Context 1
... acid (peak 1), catechin (peak 2), chlorogenic acid (peak 3), caffeic acid (peak 4), ellagic acid (peak 5), epicatechin (peak 6), rutin (peak 7), quercitrin (peak 8), quercetin (peak 9), kaempferol (peak 10), and luteolin (peak 11). 4), ellagic acid (peak 5), epicatechin (peak 6), rutin (peak 7), quercitrin (peak 8), quercetin (peak 9), kaempferol (peak 10), and luteolin (peak 11) ( Fig. 1 and Table 1). ...
Context 2
... 1-week treatment of diabetic rats with MPE (100, 200, and 400 mg/kg) decreased blood glucose levels by, re- spectively, 66, 57, and 63% blood glucose, as related to the same group before treatments (Table 2). While the treatment of diabetic rats with GLI 5 and MET 50 brought glycemia to normal levels, hyperglycemia was maintained in untreated diabetic controls ( Fig. 1/ Table 1 ). A similar profile was observed in TG and cholesterol levels (Tables 3 and 4). ...
Context 3
... other studies confirm the presence of coumarins, flavones, and flavonols in extract from leaves ( Aziz et al., 2010;Zhang et al., 2012Zhang et al., , 2010). The flavonols that are listed in Table 1 are common to many plant species, and thus not expected to have any specific role in the management of diabetes. Although this man- uscript did not identify the presence of coumarins, fla- vones or flavonols are examples of classes of compounds that can influence the pathogenesis of dia- betes in different action models as antioxidant effect (Sundaram et al., 2014;Testa et al., 2016) and inhibitory activities of α-glucosidase and α-amylase ( Zhao et al., 2015), respectively. ...
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Orange jasmine, Murraya paniculata (Rutaceae), is a plant from India widely used in folk medicine as antinociceptive, antiinflammatory, and antioxidant. Although oral hypoglycemic agents and insulin are the mainstays of treatment of diabetes mellitus (DM), there is a significant demand for new natural products to reduce the development of diabetic...
Citations
... According to research, this plant has the ability as an analgesic, anti-inflammatory, and able to treat tooth pain. As for other studies the kemuning plant has the potential as a diabetes drug because it has a glucoselowering effect [11]. Besides being used in the health sector, the Minangkabau people traditionally use yellow roots as knife stalks or ladiang (machetes). ...
Five plants i.e.Kemuning (Murrayapaniculata (L.) Jack), Temurui (Murrayakoenigii (L.) Spreng), Kuntobimo (Kigeliaafricana (Lam.) Benth. Syn. K. pinnata (Jacq.) DC.),Sala (CouroupitaguianensisAubl), and Salam (Syzygiumpolyanthum (Wight) Walp.) are regarded as types of plants that have the potential to be developed as raw materials for herbal medicine. Those five plants were planted in thespecies trial as well as ex-situ conservation plots in the Grand Forest Park Bunder, Gunungkidul at the end of 2018. This study aimsto find out more about research status of these plant types by literature review method, e.g. from books, proceedings, both print and online journals, and conducting seed evaluation in the Yogyakarta Center for Forest Biotechnology and Tree Improvement. Seed evaluation method in the nursery was conducted by measuring diameter, height and sturdiness of as many as 36 seedlings for each plant. The seed evaluation in the nursery showed the average diameter of 4.93 mm, theaverage height of 31.66 cm, and the average seedling sturdiness of 6.63. The evaluation results also show that the best seeds ready for field test planting in order are Sala, Salam, and Kemuning. As for Temurui and Kuntobimo seedlings, due to their limited height, an intensive maintenance is needed, especially fertilization, so that at the end of the year theywould also beready for field planting.
Background:
Diabetes is a metabolic disease linked to multiple comorbidities, such as low-grade inflammation. β-pinene, a monoterpene commonly found in aromatic plants, is endowed with anti-inflammatory effect and this fact lead us to investigate the possible hypoglycemic, hypolipidemic and anti-inflammatory effects of the monoterpene in the alloxan-induced diabetes experimental model.
Methods:
Male Wistar rats (200-250 g) were treated orally with β-pinene (25, 50, 100, and 200 mg/kg) or glibenclamide (5 mg/kg), for seven consecutive days. Diabetes was induced by alloxan (40 mg/kg) through the penile vein. On the seventh day of treatment, blood samples were collected for biochemical analysis. The anti-inflammatory effect of β-pinene was evaluated using the carrageenan-induced paw edema model, followed by the carrageenan-induced peritonitis.
Results:
The treatment with β-pinene decreased plasma glucose, triglyceride, VLDL, LDL, and HDL levels, when compared to those of the control group. In addition, the association β-pinene 10 mg/kg + glibenclamide 2 mg/kg significantly decreased blood glucose, total cholesterol, and triglyceride level. Finally, oral treatment with β-pinene reduced carrageenan-induced paw edema and leukocyte migration in the peritoneum. Taken together, our results indicate that β-pinene shows hypoglycemic and hypolipemic effects, which may involve some common mechanisms of glibenclamide. Besides, the monoterpene presented an anti-inflammatory action in diabetic rats that needs further investigation in order to clarify such effect and its correlation with the alterations observed in plasma parameters of β-pinene-treated diabetic rats.
