Figure - available from: Journal of Fluorescence
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Comparison of (a) peak absorbance and (b) peak fluorescence of un-irradiated and irradiated 10− 5 M Curcumin in mixture solvent with fluoride concentration. Insets show the variation of peak absorbance and fluorescence with logarithm of fluoride concentration
Source publication
The present work describes the enhanced photochemical degradation of natural dye Curcumin in acetonitrile–water mixture in the presence of fluoride upon irradiation with light. The strong basicity of fluoride modifies the solvent environment around Curcumin molecule leading to alkaline mediated degradation of Curcumin which is further accelerated b...
Citations
... Optical properties of curcumin derivatives are owing to the existence of pH, additives and polarity of solvent. Due to the easy synthesis and high sensitivity in solvent environment, they are widely used for metal ion detection [98]. Curcumin exists in two forms keto and enol, the enol form allows the molecule to accept and donate electrons, and further due to the availability of enol form it can act as metal chelator for metal ions [99]. ...
In recent years, the development of optical chemosensors for the sensitive and selective detection of trace level metal ions in aqueous media has garnered significant attention within the scientific community. This review article provides a comprehensive overview of the synthesis strategies and applications of optical chemosensors dedicated to the detection of metal ions at low concentrations in water-based environments. The discussion encompasses a wide range of metal ions, including but not limited to heavy metals, transition metals, and rare earth elements, emphasizing their significance in environmental monitoring, industrial processes, and biological systems. The review explores into the synthesis methodologies employed for designing optical chemosensors, discovering diverse materials like organic dyes, nanoparticles, polymers, and hybrid materials. Special attention is given to the design principles that enable the selective recognition of specific metal ions, highlighting the role of ligand chemistry, coordination interactions, and structural modifications. Furthermore, the article thoroughly surveys the analytical performance of optical chemosensors in terms of sensitivity, selectivity, response time, and detection limits. Real-world applications, including water quality assessment, environmental monitoring, and biomedical diagnostics, are extensively covered to underscore the practical relevance of these sensing platforms. Additionally, the review sheds light on emerging trends, challenges, and future prospects in the field, providing insights into potential advancements and innovations. By synthesizing the current state of knowledge on optical chemosensors for trace level metal ions detection. The collective information presented herein not only offers a comprehensive understanding of the existing technologies but also inspires future research endeavors to address the evolving demands in the realm of trace metal ion detection.
... In addition, it can be a prospective candidate for treating AD, because of its high anti-oxidative activity and coordination with transitional metal ions [21,22] . However, the chemical structure of curcumin is represented by two symmetric o-methoxy phenolic groups attached to the a and b-unsat- urated b-diketone which provides an opportunity to exhibit many photophysical and photochemical properties [23][24][25] . And as a fluorescent molecule, its photophysical properties such as large molar extinction coefficient, high fluorescence quantum yield and visible light excitation, as well as long- wavelength emission have been utilized for fluorescence probing sensing applications [25,26] . ...
The aim of this study was to design and synthesize amphiphilic supramolecular structures consisting of curcumin and diosgenin-terminated poly (ethylene glycol). Diosgenin, a natural plant extract, has proven to possess significant biological activities such as anti-tumor, anti-diabetes, anti-inflammatory, anti-cancer, and effect on improving memory in Alzheimer’s disease. While curcumin, the main compound of the spice turmeric, is one of the natural products that exhibits a wide range of pharmacological activities. But poor water solubility and low bioavailability of these materials have limited their clinical applications. Herein, novel amphiphilic conjugate poly (ethylene glycol) diosgenin-curcumin with improved solubility and bioavailability were developed. Cytotoxicity/anticancer effects on human fibroblast cells and human breast cancer cells are investigated with prospective potential applications in cancer therapeutics. The synthesized polymeric conjugate demonstrated non-toxic to L929 (fibroblast) cell lines but highly toxic to MCF-7 breast cancer cell lines.
Nowadays multi-drug resistant microorganisms is a serious public health problem worldwide. To overcome it, new antimicrobial strategies have been developed. Among them, antimicrobial photodynamic therapy is an efficient tool against various micro-organisms in different medical and healthcare fields. The antimicrobial photodynamic protocol is based on the interaction of a photosensitizer, molecular oxygen, and an appropriate light source. Herein, we described the main physical and chemical proprieties of curcumin, an useful natural photosensitizer, including its degradation pathways, analytical methods for quantification, extraction method, synthetic methodologies, and pharmaceutical formulations used. Moreover, a comprehensive review of the past 10 years (2010−2019) concerning the application of curcumin as photosensitizer against microorganisms is described and discussed.
