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To explore the effects of nutritional support combined with insulin therapy on serum protein, procalcitonin (PCT), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), pentraxin-3 (PTX-3), and serum amylase (AMS) levels in patients with diabetic ketoacidosis complicated with acute pancreatitis.
A total of 64 patients with diabetic ketoacidosi...
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Background
Spontaneous bacterial peritonitis (SBP) is a common and life-threatening infection in patients with decompensated cirrhosis (DC), and it is accompanied with high mortality and morbidity. However, early diagnosis of spontaneous bacterial peritonitis (SBP) is not possible because of the lack of typical symptoms or the low patient complianc...
Citations
... However, the mechanism has not yet been clarified. [6] Additionally, under the stimulation of various etiologies in vivo and in vitro, AP leads to the activation of pancreatic enzymes in the pancreas of the human body and induces inflammatory reactions such as digestion, edema, and hemorrhage in the pancreatic tissues, greatly affecting the treatment of patients with diabetes. [2] Currently, exploring effective therapy for DKA complicated with AP is urgent. ...
Background
This study aimed to provide a clinical basis for the therapy of diabetic ketoacidosis (DKA) complicated with acute pancreatitis (AP) through exploring the clinical efficacy of dexamethasone.
Methods
A total of 106 DKA patients complicated with AP admitted to Wuxi People’s Hospital Affiliated to Nanjing Medical University from January 2020 to December 2022 were selected and randomly divided into a study group (n = 53) and a placebo group (n = 53) according to the random number table method. The study group patients were given dexamethasone, while the placebo group patients were treated using placebos. Subsequently, changes of laboratory indexes and clinical symptoms before and after treatment were compared between the 2 groups, as well as adverse events after treatment.
Results
There was no significant difference between the 2 groups in terms of general information ( P > .05), indicating that the 2 groups patients were comparable. Before treatment, laboratory indexes and clinical symptoms between the 2 groups were not significantly different ( P > .05). After treatment, compared with the placebo group, patients in the study group exhibited lower levels of indicators such as random venous blood glucose, serum sodium, serum chlorine, urea nitrogen, urine glucose, urine ketone, serum amylase, and triglyceride and higher levels of PH value and serum potassium, with a statistically significant difference ( P < .05); also, the study group patients were improved significantly in clinical symptoms such as abdominal pain, nausea and vomiting, polydipsia and polyuria, diarrhea, disorders of consciousness and hypotension or shock ( P < .05). Moreover, the possibility of adverse events in the study group after treatment was much lower than that in the control group (17.0% vs 58.5%) ( P < .05).
Conclusion
Dexamethasone has a good clinical effect on DKA patients complicated with AP.
... Bupleurum can increase endogenous MOT secretion to enhance the peristalsis of the mouse small intestine; Fructus aurantii and areca have also been found to regulate gastrointestinal motility, regulate intestinal smooth muscle, and promote intestinal peristalsis. In addition, this study found that Shenling Chengqi decoction combined with routine treatment can improve the nutritional status of patients, but the results of this study showed that the nutritional status of patients was significantly improved after 7 days, but there was no significant improvement after 3 days of treatment [21]. We believe that this phenomenon may be caused by the slow process of improving the nutritional status of the body. ...
Objective. To investigate the effects of Shenling Chengqi decoction combined with routine treatment on gastrointestinal function and immune status of patients with gastrointestinal injury in severe sepsis. Methods. 160 patients with sepsis were randomly divided into a control group (n=80) and observation group (n=80). The control group was given routine treatment such as anti-infection and vasoactive drugs. The observation group was treated with Shenling Chengqi decoction on the basis of routine treatment for 7 days. The improvement of gastrointestinal symptoms, nutritional status, gastrointestinal dynamics, inflammatory response, and immune function was observed before and after treatment. The outcome indicators were evaluation of gastrointestinal symptoms, evaluation of disease severity, nutritional status, gastrointestinal dynamic indexes, inflammatory indexes, and immune function indexes. SPSS 22.0 statistical software was used for data processing. The paired t-test was used for comparison before and after treatment. Results. Compared with the control group, the disappearance time of reflux, vomiting, and recovery time of bowel sounds in the observation group were significantly shorter (P
Objective
This study aims to determine the optimal conditions for isolating and purifying the bioactive components in acerola cherry concentrate (ACC), assess their immunomodulatory effects, and establish a foundation for the extensive utilization of acerola cherry (AC).
Methods
Vitamin C (VC) in ACC was purified and characterized using optimized HPLC and NMR spectroscopy. The concentrate was divided into VC, de-VC, and AC, each with five concentration gradients. The immunoregulatory effects of each group on mice were assessed through delayed-type hypersensitivity (DTH) and carbon clearance test.
Results
VC can be isolated and purified in batches using a 100 DAC column with a loading volume of 0.3% and characterized as VC by NMR. The delayed-type hypersensitivity (DTH) results indicate a significant increase in ear weight difference between the AC1 and AC3 groups (P < 0.05). Additionally, the carbon clearance test showed a significant improvement in the VC2, de-VC1, de-VC2, de-VC3, and AC1-5 carbon clearance functions (P < 0.05).
Conclusions
The separation of VC and de-VC in ACC was successfully achieved. DTH and carbon clearance test revealed that ACC enhanced mouse immunity. However, the efficacy of the concentrate was found to diminish following isolation and purification, indicating that the VC and de-VC segments in the concentrate may have exhibited synergistic effects.
