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Comparison between normotensive and hypotensive patients according to demographic characteristics, propofol infusion, diagnosis on admission and past medical history.
Contexts in source publication
Context 1
... patient died during the follow-up. Table 1 shows demographics and clinical characteristics of the hypotensive and normotensive patients at the beginning of Propofol infusion. Indication for Propofol infusion and mean rate of infusion did not differ significantly between hypotensive and normotensive patients. ...Context 2
... patient died during the follow-up. Table 1 shows demographics and clinical characteristics of the hypotensive and normotensive patients at the beginning of Propofol infusion. Indication for Propofol infusion and mean rate of infusion did not differ significantly between hypotensive and normotensive patients. ...Similar publications
Objective
To compare the efficacy and safety of remimazolam besylate and propofol for deep sedation in critically ill patients.
Methods
In this single-center, prospective, randomized, controlled pilot study, patients in the intensive care unit (ICU) requiring deep sedation were randomized to receive remimazolam besylate or propofol intravenously....
Citations
... Additionally, diverging from other studies, an increased need for catecholamines was not detected when using sevoflurane in this susceptible patient group, aligning with the cardiovascular stability observed in patients subjected to prolonged volatile sedation [44]. Conversely, propofol sedation significantly increased the necessity for vasopressin and epinephrine [46,47], a phenomenon likely attributable to propofol's established vasodilatory effects. ...
Background
Optimal intensive care of patients undergoing valve surgery is a complex balancing act between sedation for monitoring and timely postoperative awakening. It remains unclear, if these requirements can be fulfilled by volatile sedations in intensive care medicine in an efficient manner. Therefore, this study aimed to assess the time to extubation and secondary the workload required.
Methods
We conducted a prospective randomized single-center trial at a tertiary university hospital to evaluate the postoperative management of open valve surgery patients. The study was randomized with regard to the use of volatile sedation compared to propofol sedation. Sedation was discontinued 60 min after admission for critical postoperative monitoring.
Results
We observed a significantly earlier extubation (91 ± 39 min vs. 167 ± 77 min; p < 0.001), eye-opening (86 ± 28 min vs. 151 ± 71 min; p < 0.001) and command compliance (93 ± 38 min vs. 164 ± 75 min; p < 0.001) using volatile sedation, which in turn was associated with a significantly increased workload of a median of 9:56 min (± 4:16 min) set-up time. We did not observe any differences in complications. Cardiopulmonary bypass time did not differ between the groups 101 (IQR 81; 113) versus 112 (IQR 79; 136) minutes p = 0.36.
Conclusions
Using volatile sedation is associated with few minutes additional workload in assembling and enables a significantly accelerated evaluation of vulnerable patient groups. Volatile sedation has considerable advantages and emerges as a safe sedation technique in our vulnerable study population.
Trial registration : Clinical trials registration (NCT04958668) was completed on 1 July 2021.
