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Deleted in Colon Cancer (DCC) is a tumor suppressor gene, which is deleted in 70% of Colon cancers. Here, we investigate the protein product of DCC in much detail towards a better understanding how it leads to cancers. The protein sequence was retrieved through NCBI. Three mutations in protein sequence have been identified that are associated with...
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... strand, beta turn, random coil stability, analysis of domains were performed and it was observed that mutation of single amino acid has a great affect on the domain structure and stability (Table 3). Evolutionary tree obtained by MEGA4 can be divided in three separated clusters representing each domain suggesting independent evolution of domains (Fig. 4). ...
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... F is conserved in FN3 domain except D. rerio ( Fig. 2) and mutated amino acid P shows a higher degree of variability across different organisms (Fig. 3). It was also observed from the results of MEGA4 (MSA tool) that the three domains were evolved separately as the tree is clearly separated in three different clusters representing each domain (Fig. 4). Table 3 shows the physico-chemical properties of predicted domains (using PROTPRAM and SOPMA) before and after mutation. From the results we concluded that the change of single amino acid will disrupt the confirmation of protein that may prevent it from its normal function (Table 3). Evolutionary tree suggests that the three domains ...
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