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Co-infection of Aspergillus flavus (left) and Aspergillus fumigatus (right). From caseous nodules and heart lesions.
Source publication
Confirmatory diagnosis of invasive aspergillosis is paramount to ensure proper treatment and effective
management of the disease in food and companion animals. Suspected invasive aspergilllosis in
chickens was encountered at post-mortem. Morphological and molecular methods were employed to
identify Aspergillus from samples collected from dead ch...
Contexts in source publication
Context 1
... were aseptically taken from the nodules and heart lesions from the chickens and cultured on Sabouraud dextrose agar at 30ºC for 7 days. Greenish and yellowish colonies were observed on the surface of the media (Figure 2). A small amount of the colonies was removed from the culture, stained with lactophenol cotton blue and observed under a biological microscope to study fungal morphology. ...
Context 2
... were aseptically taken from the nodules and heart lesions from the chickens and cultured on Sabouraud dextrose agar at 30ºC for 7 days. Greenish and yellowish colonies were observed on the surface of the media (Figure 2). A small amount of the colonies was removed from the culture, stained with lactophenol cotton blue and observed under a biological microscope to study fungal morphology. ...
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Objective:
Invasive aspergillosis of the central nervous system in immunocompetent patients is a rare disease. We present in this study three cases that were treated in our centre and reviewed the results of similar studies from Saudi Arabia.
Methods:
We retrospectively reviewed all cases of invasive aspergillosis of the central nervous system (...
Citations
... The primary cause is A. fumigatus, though other species such as A. niger, A. nidulans, A. flavus, and various Aspergillus species, sometimes in mixed infections, also play significant roles [1,5]. Aspergillus fumigatus predominates in respiratory fungal infections likely due to its smaller, easily airborne spores [6]. Avian aspergillosis affects various domesticated and wild birds, particularly those in captivity, and can lead to substantial economic losses due to high morbidity, mortality, and compromised growth and feed efficiency in affected birds [1,5,7,8]. ...
Aspergillus fumigatus is recognized as a significant respiratory pathogen in poultry,
causing substantial economic losses and severely impacting farmers’ livelihoods. This
case report details the laboratory diagnosis of a clinical outbreak of A. fumigatus on
a poultry farm in Jos, Plateau State, Nigeria. The diagnosis was made using a combination
of historical data, clinical signs, postmortem examination, histopathology, and
microbial culture, and identification. Notable findings included nodular lesions on the
lungs and peritoneum, with fungal hyphae embedded within the lung tissue. Microbial
culture revealed characteristic macroscopic features of A. fumigatus and the presence of
Escherichia coli, indicating a potential secondary bacterial infection. Treatment involved
administering 500,000 IU oral nystatin at 320 tablets per day for 14 days (1 tablet per 10
kg body weight) and Florum® (20% florfenicol) at 1mL per 2L of drinking water for 5 days.
The farmer was advised to implement measures to enhance biosecurity, sanitation, and hygiene on the farm. Two weeks after treatment, the farmer recorded zero mortality even though he could not keep track of the actual number of dead birds, he however, estimated about 100 mortality. The farmer also acknowledged that the birds started laying at 17 weeks. A second farm visit when the birds were 19 weeks old also showed that they were thriving well and no mortality was recorded. This case report underscores the importance of accurate diagnosis for the early detection and prevention of disease agents and ensuring rational antimicrobial use for therapeutic purposes.
