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Allergy to citrus fruits is often associated with pollinosis and sensitization to other plants due to a phenomenon of cross-reactivity. The aims of the present study were to highlight the cross-reactivity among citrus and the major allergenic pollens/fruits, throughout clinical and molecular investigations, and to evaluate the sensitization frequen...
Citations
... Due to a phenomenon called cross-reaction, allergy to oranges is often associated with pollinosis and sensitization to other plants [22]. Using reverse primer R1, a total of 56 fragments were amplified in all Citrus sinensis varieties. ...
... Clinically, since EEP is a fruit-based product, this irrigant might not be suitable to be used on patients with citrus allergies. Although the prevalence is rare [71], precautionary measures should be taken, which may limit its application in clinical settings. Exploration of the antibiofilm activity of EEP at 6.25% against the multi-species bacteria that cause endodontic infection should be investigated in the future. ...
Concerns have been raised about the usage of sodium hypochlorite (NaOCl) in endodontics following its toxic effects. Effective ecoproduce (EEP), an organic solution produced through the fermentation of fruit peels, exhibits antibacterial and antibiofilm action, suggesting its potential as an endodontic irrigant. However, studies on its cytotoxicity are limited. This in vitro study aimed to evaluate the cytotoxic effects of EEP at different concentrations and fermentation periods against the MC3T3-E1 cell. EEP derived from orange and pineapple peel waste and fermented for 3 and 6 months was prepared from 100% to 0.78% concentration. Briefly, 2.5% NaOCl was used as the comparison group. Cell viability was analysed using Alamar Blue and Live and Dead Cell assay. A transmission electron microscope (TEM) was used to evaluate ultrastructural changes to the cells. Data analysis was performed using a two-way mixed Analysis of Variance (ANOVA). EEP exhibited concentration-dependent cytotoxicity regardless of the fermentation period (p > 0.05). A concentration below 6.25% was non-cytotoxic and comparable to the negative control (p > 0.05). Live and Dead Cell assay and TEM analysis complement the findings. The mean cell viability of EEP at all concentrations for both fermentation periods was significantly higher than that of 2.5% NaOCl (p < 0.05). Conclusively, 6.25% EEP fermented for 3 and 6 months are non-cytotoxic and can serve as an alternative endodontic irrigants.
... El estudio de Lorio y Luca señala que el camu camu provocó alergia alimentaria en 1 de los pacientes reclutados para su muestra, y estimaron un 39% de sensibilización a los frutos cítricos y el mecanismo mediado fue por IgE, además de presentar reactividad cruzada. 11 En adición, las frutas cítricas también contienen diversas moléculas bioactivas (flavonoides, ácido ascórbico, entre otros componentes), con capacidad de producir efectos antibacterianos, antivirales, incluso antiinflamatorios, que pueden utilizarse en forma de extracto para contrarrestar los síntomas de la alergia alimentaria (estos compuestos tienen función importante en la vía de las interleucinas). 12 Con base en estos hallazgos, es importante ampliar el campo de investigación respecto a las sustancias que contienen los frutos cítricos. ...
Objetivo:
Determinar la frecuencia de alergia alimentaria en general, y de productos de consumo común oriundos del Perú, en estudiantes de medicina humana.
Métodos:
Estudio observacional, descriptivo y retrospectivo, al que se incluyeron estudiantes de medicina humana de 18-25 años, de una universidad privada del Perú, seleccionados mediante muestreo tipo “bola de nieve” a través de mensajería electrónica. El tamaño de la muestra se calculó con el programa OpenEpi v3.0 y la fórmula de prevalencia.
Resultados:
Se registraron 355 estudiantes, con edad media de 20.9 años (SD ± 5,01). La frecuencia de alergia alimentaria fue de 9.3% del total de la muestra; y la frecuencia de alergia a productos de consumo común (oriundos del país) reportó: mariscos 2.24%, especias y condimentos 2.24%, frutas 1.4%, leche 1.4% y carnes rojas 0.84%.
Conclusiones:
Existe una frecuencia de 9.3% de alergia alimentaria autorreportada, producida por productos de consumo común (oriundos del Perú) a nivel nacional.
... Учитывая высокую чувствительность и специфичность прик-прик теста с нативным яблоком и ОФПТ с раствором яблочного сока, полученная чувствительность прик-прик теста с мандарином и ОФПТ с растворами водно-солевого экстракта и сока мандарина (53 и 44 %) может отражать процент истинноположительных реакций на мандарин, что соответствует распространённости истинной ПА на цитрусовые в популяции лиц с поллинозом [26]. В случае отрицательного результата предложенных тестов реакцию на цитрусовые следует рассматривать как неспецифическую. ...
... 26 To elaborate with an example: two major orange allergens are Cit s 2, profilin, 27 and Cit s 3, a lipid transfer protein (LTP). 28 Profilins are known for their ability to cross-react with grass pollens and LTPs with LTP allergens of other fruits such as Pru p 3 in peach. 28 Interestingly, orange fruit allergenic extracts have also been shown to cross-react with orange tree pollen. ...
... 28 Profilins are known for their ability to cross-react with grass pollens and LTPs with LTP allergens of other fruits such as Pru p 3 in peach. 28 Interestingly, orange fruit allergenic extracts have also been shown to cross-react with orange tree pollen. 29 Several recent studies shed light on the significance of sesame seed allergy in the Middle East, 10,14 sometimes referring to it as the "Middle Eastern peanut". ...
Background
Despite the recognition of food allergies as a significant cause of morbidity and a growing public health burden worldwide, there are no epidemiological studies addressing food sensitization and allergy in Jordan.
Objective
To conduct an epidemiological study that retrospectively analyzes sensitization data from 3463 patients with suspected immunoglobulin E (IgE)‐mediated food allergic reactions who performed specific IgE tests in our laboratories in Jordan.
Methods
Specific IgE (s‐IgE) tests were analyzed for patients who performed enzyme allegro‐sorbent testing based on either self‐reported food allergy or upon physician's request.
Results
2.3% of the analyzed samples were cross‐reactive to carbohydrate determinants. A quarter of the patients were sensitized to one or more food allergens, with males having higher odds of being s‐IgE positive. Furthermore, a higher prevalence of sensitization was seen in infants and children compared with adults. s‐IgE was most frequently found against cow milk (11.2%), pistachio (4.9%), soybean (4.6%), cherry (4.4%), and orange (4.4%). Interestingly, the s‐IgE class distribution profile of pistachio differed from the rest of the top hits being skewed away from the weak class 1 leaning more towards higher IgE classes. Food allergen sensitization was age group‐dependent: milk, tree nuts, and eggs were the main food groups causing sensitization in infants, while it was fruits followed by milk in children and adults.
Conclusions
Our work represents the first epidemiological study addressing food sensitization in Jordan. This study lays a solid foundation for future studies that can help better guide food allergy diagnosis, patient dietary modifications, and food elimination plans, as well as assist decision‐makers in the region to develop national strategies for an efficient and sustainable healthcare system.
... Epidemiology studies show permanent increase number of allergy patients. About 2% of world population has got food allergy and up to 3% of adults has got contact allergy , (Iorio, Del Duca et al. 2013), (D'Amato, Cecchi et al. 2010). Citrus allergens can lead to gastrointestinal and skin symptoms and because of cross reaction inhalant symptoms also (Iorio, Del Duca 2013). ...
... About 2% of world population has got food allergy and up to 3% of adults has got contact allergy , (Iorio, Del Duca et al. 2013), (D'Amato, Cecchi et al. 2010). Citrus allergens can lead to gastrointestinal and skin symptoms and because of cross reaction inhalant symptoms also (Iorio, Del Duca 2013). ...
This is the 3rd. book in the scientific book series entitled „Advances in biomedical research”.This book series is the result of the meetings and hard work of young scientists from various universities and institutes in Poland.In this monograph we present the topics in Biomedical Research from 2019. All presented articles have passed the peer-review process positively. The articles come from various fields of biomedicine from microbiology throughout regenerative medicine&rehabiliation to cancer research.
Wishing you enjoyable and productive reading.
Editors,
Łukasz Biały MD, PhD Izabela Młynarczuk-Biały MD, PhD
FULL TEXT LINK: http://bc.wydawnictwo-tygiel.pl/publikacja/C79E0468-B924-453E-E1ED-6E8D05D1001B
... 17,18 The most common of these foods are citrus and nightshade vegetables, which are thought to generate sensitivities in large proportions of the population. 19,20 Several diet-associated antigens have also been identified, although the mechanisms by which they exert their effects on the immune system have not been well-elucidated. ...
Introduction:
Inflammation underlies a variety of chronic medical conditions, including diabetes. The anti-inflammatory diet, one that excludes foods that may stimulate inflammation and includes foods that reduce inflammation, may improve inflammatory biomarkers in people with diabetes and pre-diabetes.
Study design:
Thirty participants with diabetes or pre-diabetes were randomized (2:1) in a controlled feeding study that compared the anti-inflammatory diet (n=20) to a control diet (n=10) based on the American Diabetes Association recommendations. Diets were matched for protein, carbohydrate, fat, and fiber content as closely as possible. Participants were fed an isocaloric diet for 2 weeks, followed by continued ad libitum feeding in their dietary group assignment for an additional 4 weeks. All meals were prepared by the study team.
Outcomes:
Primary outcomes included inflammatory markers, including cytokines and hsCRP. Secondary outcomes included body weight and biomarkers for cardiovascular disease and diabetes.
Results:
Both diets resulted in trends in reduced markers of inflammation, especially with weight loss. In addition, glucose, lipids, and triglycerides all trended downward, also non-significantly and equally in both groups.
Conclusion:
Dietary change can improve inflammation as well as other cardiometabolic risk factors. In this study, the anti-inflammatory diet did not affect markers of inflammation more than the control diet.
... Citrus fruits are a common allergen 37,38 that increase the risk of atopic diseases and are often seen as a trigger for IBS. 39,40 Upon asking, MH mentioned that she noticed bloating on occasions after consuming tangerines. ...
Chronic joint or musculoskeletal pain is the leading cause of disability in the United States and worldwide. Current treatment options are limited in their ability to alter disease outcome. Recent studies are unequivocal about the inflammatory origins of musculoskeletal pain and prove that nutritional therapy can be a cost-effective option to improve patient outcomes in clinical care. This case study examines the effect of a nine-week nutritional intervention in a 47-year-old female with an eight-year chronic pain in her shoulders and knees. The nutritional program included a three-week Elimination Diet Food Plan, followed by a Detox Food Plan. Both diet plans followed guidelines offered by the Institute for Functional Medicine®. The client also had secondary complaints that included nausea, bloating, a foul taste in her mouth, and adult-onset acne. After nine weeks, the client achieved nearly full range of motion in her shoulders. Knee movements improved significantly, and the client was able pursue physical activities without pain. During this time, all digestive issues resolved and skin breakouts reduced, though skin lesions remained.
... Sin embargo las creencias pueden variar entre países, padres mexicanos reportaron que la leche, camarones y otros mariscos pueden causar alergia; padres noruegos reportan que las frutas, chocolate, nueces (4) pueden causar alergia. En nuestra muestra encontramos la creencia de que los cítricos pueden causar mayoritariamente alergias; aunque se ha identificado sensibilización a cítricos, generalmente por reacción cruzada con proteínas homólogas a las del polen, la alergia es raramente observada (5) . ...
... Two consensus sequences were obtained homologous to PLA21 (Genbank ID: EEF38745) and PLA23 (EEF48118) of Ricinus communis. This sequence showed high homology in citrus pollen [40]. The apple PLA21-like fragment sequence is similar to A. thaliana PLA 2 -β and it is positioned on apple LG13 where, according to v 1.0 of apple genome, two putative coding sequences for phospholipase (MDP0000154214 and MDP0000249250) were found very close to each other, differing only for a couple of SNPs (Table 1). ...
... The presence of PLA 2 transcripts in pollen was recently demonstrated in A. thaliana, where three out of four PLA 2 paralogs (PLA 2 -β, −γ and −δ) were expressed during pollen development; in this process, as well as during pollen germination and tube growth, endoplasmic reticulum and Golgi-localized PLA 2 plays critical roles [41]. Moreover, the expression of two isoforms of secretory phospholipases (sPLA 2 α and β) was found to increase during germination of Citrus clementine pollen [40]. As in Citrus, we also identified the putative isoforms −α and −β of PLA 2 genes and located them in tandem on chromosome 13. ...
Allergy to freshly consumed apple fruits is often associated to pollinosis and manifested as oral allergy syndrome (OAS). The allergenic properties of apple varieties differ greatly, spanning from low allergenic to high allergenic varieties. The knowledge of the genetic determinants for allergenicity has been of great interest in scientific community for several years, but the molecular mechanisms involved are still little understood. Here, factors putatively involved in allergenicity were investigated at biochemical and molecular level in pollen and in fruits of apple varieties differing in their allergenic potential. Among putative sensitizing factors, transglutaminase (TGase) and phospholipase A2 (PLA2) were considered together with reactive oxygen species (ROS) and known apple allergen genes, with particular attention devoted to the Mal d 1 gene family, the most important one in sensitization. We found that the expression of some allergen genes and the activities of TGase, PLA2 and ROS producing enzyme are lower in the hypo-allergenic variety ‘Durello di Forlì’ in comparison with the high-allergenic genotypes ‘Gala’ and ‘Florina’. These results highlight correlations among allergen expressions, enzymatic activities and apple cultivars; these data underline the possibility that some of them could be used in the future as markers for allergenicity.
