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Clinical Staging of Mast Cell Tumors
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... histologic grade re- mains the gold standard for predicting the biologic behavior of cutaneous mast cell tumors, other prognostic factors include tumor location, proliferative indices, breed, recurrence, c-kit mutations, c-kit staining pattern, and microvessel density. [4][5][6][7][8][9][10][11] In addition to biologic behavior, the ap- propriate treatment for canine mast cell tu- mors will also be dictated by the extent of disease, referred to as the clinical stage ( Table 2). To determine the clinical stage in dogs with mast cell tumors, a complete blood count, a serum chemistry profile, urinalysis, a thoracic radiographic examina- tion, and an abdominal ultrasonographic examination should be performed before instituting therapy. ...
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Mast Cell Activation Syndrome (MCAS) is an immunogenic disorder typically presenting with episodic multi-organ symptoms, caused by the inappropriate and aberrant release of mast cell mediators. Symptoms may be severe, including anaphylaxis and often occur in response to specific triggers which include many drugs and potentially chemo...
