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Background: Acute lymphoblastic leukemia (ALL) is a disease caused by a mutation of lymphoid progenitor cells in bone marrow, that induces uncontrolled lymphoid cell proliferation. ALL is the most common type of leukemia in children. Various clinical and laboratory manifestation makes the diagnostic process more complicated. This study aimed to obs...
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... and bone pain (30.6%). Research conducted at Hasan Sadikin Hospital showed that the clinical manifestations that often appeared were paleness, hepatomegaly, and fever [10]. A systematic review and meta-analysis study by Clarke at al (2016) showed that the five most common symptoms in >50% of ALL children were hepatomegaly, splenomegaly, pallor, fever, and bruising [16] Meanwhile, a study in Saudi Arabia showed that the most common symptoms in ALL children were fever, fatigue, bone pain, paleness, weight loss, and decreased consciousness [17]. ...
... Most patients had a platelet level of 20,000−99,000/uL at 52.8%. Previous research at Hasan Sadikin Hospital found that severe anemia with hemoglobin levels <7 g/dL occurred in 44.8% of cases, leukocytosis occurred in 46.9% of cases, and severe thrombocytopenia occurred in 55% of cases [10] Other studies showed that at the time of diagnosis, the median leukocytes were 7120/uL (450−600,000/uL), the median hemoglobin was 7.5 g/dL (2,4−15.3 d/dL), the median platelets were 47,400/uL (4,000−544,000 /uL). ...
... The research showed that LLA was more common in boys (52.8%). Previous research at Hasan Sadikin Hospital in Bandung in 2016 obtained the same results, namely, the majority of ALL occurred in boys, as did other studies [10][11][12]. A systematic review and meta-analysis conducted in Indonesia showed that ALL was more common in boys, 2.45 per 100,000 children, than in girls, 2.05 per 100,000 children [13]. ...
Objective: We examined differences of vitamin D levels at initial diagnosis and after induction phase chemotherapy in children with Acute Lymphoblastic Leukemia (ALL). Methods: A cross-sectional study was conducted on newly diagnosed children with ALL from October 2021 until October 2022 at Dr. Hasan Sadikin Hospital−Bandung, West Java, Indonesia. Vitamin D levels were measured twice using blood samples: at initial diagnosis and after the remission induction phase of chemotherapy. A paired t-test was applied and the value of p<0.05 is considered as statistically significant. Result: There were 53 subjects that fulfilled research criteria. Thirty−six subjects met the inclusion criteria while 17 were excluded. Majority of ALL patients were male (52.8%) and aged 1−10 years (83.3%). Mean vitamin D level of ALL children at initial diagnosis was 16.68±9,56 ng/mL. After the induction phase of chemotherapy, mean vitamin D level was 11.84±7,8 ng/mL. Paired t-test was performed to obtain p value = 0.000. Conclusion: The prevalence of hypovitaminosis D in ALL children is 88.8%. Vitamin D levels after chemotherapy are lower than at initial diagnosis.
