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Previous studies have reported that different blood groups are associated with the risk of chronic degenerative diseases that mainly involve inflammation and neoplastic processes. We investigate the relationship between blood groups and the erythroprotective effect of extracts from Navicula incerta against oxidative damage as a proposal to develop...
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... Artemia salina bioassay evaluated the acute toxicity of the extracts from N. incerta using the Molina-Salinas [23] and Leos-Rivas [24] method with some modifications. The toxicity of samples was classified according to Robles-García et al. [25], as indicated in Table 1. To hatch A. saline cysts (100 mg), it was necessary to use 1 L of sterile seawater (35 PSU). ...Citations
... Vitamin C (L-ascorbic acid) is an important reducing agent, capable of donating electrons and protons to receptor molecules such as free radicals. In relation to the reducing potentials of antioxidants, they play a very important role in inhibiting oxidation and cytoprotective effects (neuroprotective, hepatoprotective and erythroprotective effects), preventing the development of chronic diseases related to oxidative stress, such as neurological [9], hemolytic [10][11][12] and carcinogenic processes [11,13]. ...
... Vitamin C (L-ascorbic acid) is an important reducing agent, capable of donating electrons and protons to receptor molecules such as free radicals. In relation to the reducing potentials of antioxidants, they play a very important role in inhibiting oxidation and cytoprotective effects (neuroprotective, hepatoprotective and erythroprotective effects), preventing the development of chronic diseases related to oxidative stress, such as neurological [9], hemolytic [10][11][12] and carcinogenic processes [11,13]. ...
... Recent research suggests that microalgae extracts act as important erythroprotective agents, reducing oxidative stress depending on the surface antigen of the erythrocytes [10][11][12]. Fucoxanthin and β-Carotene are among the most important and abundant marine carotenoids in algae and microalgae since they contribute more than 10% of the total estimated production of carotenoids in the marine environment [17]. These pigments have generated great interest in the pharmaceutical food industry due to their various health-beneficial properties, promoting pharmacological effects related to oxidative stress [13,18,19]. ...
Previous studies detail that different blood groups are associated with incidence of oxidative stress-related diseases such as certain carcinomas. Bioactive compounds represent an alternative for preventing this oxidative stress. The aim of this study was to elucidate the impact of blood groups on the erythroprotective potential of fucoxanthin, β-Carotene, gallic acid, quercetin and ascorbic acid as therapeutic agents against oxidative stress. The impact of ABO blood groups on the erythroprotective potential was evaluated via the antioxidant capacity, blood biocompatibility, blood susceptibility and erythroprotective potential (membrane stabilization, in vitro photostability and antihemolytic activity). All tested antioxidants exhibited a high antioxidant capacity and presented the ability to inhibit ROO•-induced oxidative stress without compromising the cell membrane, providing erythroprotective effects dependent on the blood group, effects that increased in the presence of antigen A. These results are very important, since it has been documented that antigen A is associated with breast and skin cancer. These results revealed a probable relationship between different erythrocyte antigens with erythroprotective potential, highlighting the importance of bio-targeted drugs for groups most susceptible to certain chronic-degenerative pathologies. These compounds could be applied as additive, nutraceutical or encapsulated to improve their bioaccessibility.
... The antihemolytic capacity of a 0.75 mM PC sample was determined to be 97%, however, the blood group of the experiment was not specified [31]. Additionally, it was evaluated the erythroprotective effect of extracts from the Navicula incerta and obtained high percentages of hemolysis inhibition with an acetone (89.20% ± 0.70), methanolic (96.70% ± 1.10), and ethanolic (81.80% ± 3.20) extract on group O [102]. Based on the same type of extract and blood group, in the present work, the percentage of inhibition of hemolysis detected was higher (100.00% ...
There are multiple associations between the different blood groups (ABO and RhD) and the incidence of oxidative stress-related diseases, such as certain carcinomas and COVID-19. Bioactive compounds represent an alternative to its prevention and treatment. Phycobiliproteins (PBP) are bioactive compounds present in the microalga Porphyridium cruentum and, despite its antioxidant activity, their inhibitory effect on hemolysis has not been reported. The aim of this work was to evaluate the erythroprotective potential of phycobiliproteins from P. cruentum in different blood groups. The microalga was cultured in F/2 medium under controlled laboratory conditions. Day 10 of culture was determined as the harvest point. The microalgal biomass was lyophilized and a methanolic (MetOH), Tris HCl (T-HCl), and a physiological solution (PS) ultrasound-assisted extraction were performed. Extract pigments were quantified by spectrophotometry. The antioxidant activity of the extracts was evaluated with the ABTS+•, DPPH•, and FRAP methods, finding that the main antioxidant mechanism on the aqueous extracts was HAT (hydrogen atom transfer), while for MetOH it was SET (single electron transfer). The results of the AAPH, hypotonicity, and heat-induced hemolysis revealed a probable relationship between the different antigens (ABO and RhD) with the antihemolytic effect, highlighting the importance of bio-directed drugs.
