Fig 1 - available from: Arthritis Research & Therapy
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Classification flow diagram. C-GCA, cranial giant cell arteritis; LV-GCA, large-vessel giant cell arteritis; LVV, large-vessel vasculitis; PMR, polymyalgia rheumatica; STA, superficial temporal artery; TAK, Takayasu arteritis; UEOLVV, unclassified EOLVV
Source publication
Background
This study aimed to identify new characteristics of elderly onset large-vessel vasculitis (EOLVV) by focusing on human leucocyte antigen (HLA) genotype, polymyalgia rheumatica (PMR), and affected vascular lesions observed on positron emission tomography/computed tomography (PET/CT) imaging.
Methods
We retrospectively studied 65 consecut...
Contexts in source publication
Context 1
... of this study A total of 65 patients who had LVV with extracranial LVV lesions were divided into two groups according to age, with a cutoff of 50 years: 25 patients with youngonset LVV diagnosed as TAK and 40 patients with EOLVV. Among the 40 patients with EOLVV, 13 were diagnosed with LV-GCA, whereas the remaining 27 were categorized as UEOLVV (Fig. ...
Context 2
... and PET/CT findings between patients who had UEOLVV with PMR and those with LV-GCA To classify EOLVV based on the HLA genotype, presence of PMR, and affected vascular lesions detected through PET/CT imaging, we initially focused on PMR, subsequently classifying the 27 patients with UEOLVV into two groups: 11 and 16 patients with and without PMR (Fig. 1). Accordingly, patients who had UEOLVV with PMR had higher HLA-B52 positivity and different clinical and laboratory characteristics compared to those without PMR (Table 1). There was no difference in HLA-DR between the two groups. In contrast, patients who had UEOLVV with PMR demonstrated almost similar clinical and laboratory features ...
Context 3
... the other hand, no such clustering was observed in patients who were HLA-B52-negative (Fig. 2). Additionally, the evaluation of the distribution of the affected vessels showed that patients who had UEOLVV with PMR and those with LV-GCA had almost the same number and similar diffuse pattern of affected vessels, including the axillary artery (Supplementary Figure S1 and Table S1). These results suggest that UEOLVV with PMR and LV-GCA may exhibit similar characteristics, especially in patients who were HLA-B52-positive (Fig. 2). ...
Citations
... We have read with interest the article published in Arthritis Research & Therapy by Kushimoto et al. suggesting that the HLA-B*52 allele may indicate the presence of diffuse extracranial large vessel vasculitis (LVV) in patients with giant cell arteritis (GCA) [1]. GCA is the prototype of LVV that affects people over 50 years of age, especially those of European descent [2]. ...
... Kushimoto et al. evaluated 40 Japanese patients over 50 years of age who were categorized as elderly-onset LVV (EOLVV) that showed diffuse vascular lesions similar to those found in extracranial LVV-GCA, 13 of them also had temporal artery involvement, while 27 did not [1]. The 27 patients with isolated extracranial EOLVV were classified into two groups: 11 and 16 patients with and without PMR. ...
... The 27 patients with isolated extracranial EOLVV were classified into two groups: 11 and 16 patients with and without PMR. The 11 extracranial EOLVV patients with PMR and the 13 patients with both cranial and extracranial involvement formed a cluster of patients who were Open Access HLA-B*52 positive [1]. However, we could not demonstrate a higher prevalence of the HLA-B*52 allele in Spanish patients with extracranial GCA [10]. ...
