Fig 1 - uploaded by Thai-Son Tran
Content may be subject to copyright.
Download
View publication
Claisen-Schmidt condensation reaction in chalcones synthesis

Claisen-Schmidt condensation reaction in chalcones synthesis

Source publication
Fig. 1. Claisen-Schmidt condensation reaction in chalcones synthesis
Fig. 5. The correlation between docking scores and bioactivities of...
Fig. 6. (A) 2D and and (B) 3D interactions between S17 and the active...
The content of each sample in in vitro assay
+2 Acetylcholinesterase inhibitory activities of studied chalcone compounds
Synthesis, in vitro Acetylcholinesterase Inhibitory Activity Evaluation and Docking Investigation of Some Aromatic Chalcones
Article
Full-text available
  • Dec 2017
In this study, a total of twenty chalcones were synthesized via Claisen-Schmidt condensation reaction and evaluated for their in vitro acetylcholinesterase inhibitory activities using Ellman’s method. Molecular docking studies on acetylcholinesterase were performed to elucidate the interactions between these chalcone derivatives and acetylcholinest...
Cite
Download full-text

Context in source publication

Context 1
... condensation reaction [66] was applied to synthesize chalcones (Fig. 1). The reaction of acetophenone and benzaldehyde derivatives in KOH/ of concentrated HCl provided S1-S20 with satisfactory yields after re-crystallized from appropriate solvents. The by IR and 1 H-NMR ...

Similar publications

Figure 2
Figure 3
Table 3
Figure 4 The HSA d norm map of both sides of the molecule, showing CÁ Á...
+3 Figure 5
2-Benzyloxynaphthalene Aminoalkylated Chalcone Designed as Acetylcholinesterase Inhibitor: Structural Characterisation, in vitro Biological Activity and Molecular Docking Studies
Article
Full-text available
  • Jul 2020
The design of an acetylcholinesterase inhibitor with multifunctional properties became the perspective for the development of an effective drug against Alzheimer's disease. Towards this target, 1-{4-hydroxy-3-[(piperidin-1-yl)methyl]phenyl}ethan-1-one (chalcone 3) was prepared and studied as an acetylcholinesterase inhibitor. The novel chalcone 3 w...
View