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Pterocarpus erinaceus (Fabaceae) is a medicinal plant used in the treatment of several diseases such as, fever, diarrhea, and dysentery. The aim of this research work is to isolate phytochemicals, evaluate antimicrobial and cytotoxic activities of the extract/isolated compounds from the stem bark of Pterocarpus erinaceus. The plant material was air...
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... At the chemical level, compounds belonging to polyphenols, tannins, alkaloids, flavonoids, saponins, anthocyanins and anthraquinons 20 could be responsible for the in vivo antisalmonellal activity of Khaya grandifoliola. This antisalmonellal properties can be due to the action of one or more specific active components of the extract; this explanation corroborates the finding of Sokoudjou et al. 28,29 who showed that some compounds including scopoletin and canarimoic acid isolated from the stem barks of Canarium schweinfurthii were active against Salmonella Enteritidis and Salmonella Typhimurium. In addition, some compounds belonging to the classes of terpenoids, flavonoids, polyphenols and alkaloids are well known for their antisalmonellal activities 28,[30][31][32][33] . ...
... This antisalmonellal properties can be due to the action of one or more specific active components of the extract; this explanation corroborates the finding of Sokoudjou et al. 28,29 who showed that some compounds including scopoletin and canarimoic acid isolated from the stem barks of Canarium schweinfurthii were active against Salmonella Enteritidis and Salmonella Typhimurium. In addition, some compounds belonging to the classes of terpenoids, flavonoids, polyphenols and alkaloids are well known for their antisalmonellal activities 28,[30][31][32][33] . Finally, this antisalmonellal potential in broilers may be linked to the ability of these secondary metabolites to directly kill Salmonella or boost the immune system of the host. ...
Salmonella infections remain one of the major health problems in both poultry farming and human medicine. In addition, resistance to Salmonella has emerged as a global health problem in both sectors. The present study aimed at evaluating the in vivo antisalmonellal and antioxidant activities of 95° ethanol extract of Khaya grandifoliola using broiler chickens as animal model. Animals were divided into the normal control group, negative control group, positive control group and three test groups treated with the extract at 10, 20 and 40 mg/kg respectively. The antioxidant status of broiler chickens was also evaluated by measuring the concentration of enzymatic antioxidants (catalase, glutathione peroxidase) and biochemical markers (malondialdehyde and nitric oxide). The results showed that infected animals treated with the Khaya grandifoliola extract at 40 mg/kg recovered on day 11 after the beginning of the treatment and on day 13 for those treated at the 10 and 20 mg/kg. The antioxidant assay showed that the infection led to the reduction of enzymatic markers in the body of infected animals, while the treatment increases such makers. The infection resulted in a significant increase in serum and pulmonary malondialdehyde. It also caused a significant decrease in cardiac and pulmonary nitric oxide whereas the treatment depending on the doses of the extract tends to normalize these biochemical markers. The overall results showed that Khaya grandifoliola extract can be successfully used in the treatment of avian salmonellosis as well as the management of the oxidative stress caused by the infection.
... The wide range of antisalmonellal properties can be explained by the qualitative and/or quantitative variation of various groups of potentially active secondary metabolites. [20] Indeed, the phytochemical screening of the extracts of Khaya grandifoliola revealed the presence of certain classes of compounds whose members have already been known to exhibit antisalmonellal activities like alkaloids, [21,22] flavonoids [23] and polyphenols. [24] The phytochemical screening of the various extracts of Khaya grandifoliola revealed the presence of several classes of secondary metabolites: Given that polyphenols, tannins, alkaloids, flavonoids, saponins, anthocyanins and anthraquinons were presents in all the extracts, the antisalmonellal property of Khaya grandifoliola could be attributed to the presence of these secondary metabolites which may act by a synergistic mechanism. ...
... [25] Some flavonoids have shown several pharmacological activities including antibacterial and antifungal. [23,26] Alkaloids have been reported to exhibit antisalmonellal activities. [21,22] Many saponins are known to be antimicrobial. ...
Salmonella infections remain a significant problem in the veterinary and human health sector. In addition, the inappropriate use of antibiotics as growth factor or against infectious diseases has led to resistance issues, especially in poultry farm. The aim of this study was to evaluate the in vitro antisalmonellal and antioxidant properties of Khaya grandifoliola in order to develop new control strategies against salmonellosis. The antisalmonellal properties of Khaya grandifoliola were evaluated (against two isolates and one strain of Salmonella) by serial dilution method while the antioxidant activities and phytochemical screening were performed using standard methods. The result showed that the 95% ethanol and hydroethanolic 70% extracts of Khaya grandifoliola were the most active against Salmonella Typhimurium and Salmonella Typhi, having the same MIC (128 µg/ml). For the DPPH • radical scavenging activity, all the hydroethanolic extracts and decoction showed IC 50 ˂ 12.5 µg/ml while the IC 50 of infusion and the maceration were 39.57 µg/ml and 15.16 µg/ml, respectively. In the FRAP assay, the reducing power of the 70% ethanol extract is the highest of all the extracts (1.46) at a concentration of 50 μg/ml followed by 50% and 30% ethanolic extracts. At 200 µg/ml, the WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 7.632 Yamako Konack et al. World Journal of Pharmacy and Pharmaceutical Sciences 95% ethanol extracts, 70% and the infusion showed the strongest reducing power of iron (1.41). At the highest concentration (200 µg/ml), the anti-radical power of hydroxyl is highest for the 95% extracts (11.00), followed by maceration and 30% hydroethanolic extract. The overall results of this study showed that extracts of Khaya grandifoliola especially the 95% ethanol extract can be successfully used as alternative treatment against salmonellosis.
