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... biomarkers viz. Swertiamarin (ASB-00019440-005), Sweroside (ASB-00019435-010), Swertisin (ASB-00019441-010), Amarogentin (ASB-00001650-010), Luteolin (ASB-00012461-025), and Genistein (ASB-00007098-010) (Figure 1) of the Swertia herbs were procured from Chromadex, USA. Antioxidant assay reagent 2, 2-diphenyl-1-picrylhydrazyl (DPPH), β-carotene, tween-40 and linoleic acid were procured from Sigma-Aldrich (USA), and MP Biomedicals, India respectively. ...
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To prepare silver nanoparticles mediated by aqueous leaf extracts of Swertia chirayita and Punica granatum, the leaves of both plants were collected, washed and dried in shade and powdered. Using distilled water as media, aqueous extracts was obtained using Soxhlet extraction unit. The aqueous extracts were subjected to phytochemical screening to r...
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... The re sults are in line with pre vi ous re ports on Swer tia species where ace tone proved bet ter for ex trac tion of an tiox i dants ( Singh et al., 2012 ). How ever, re cent in vesti ga tions on Swer tia species sug gest the util ity of di verse sol vent systems for ex trac tion of phy to con stituents from Swer tia species ( Kshirsagar et al., 2014b ;Das et al., 2013 ;Ghadage et al., 2017 ;Srivastava et al., 2018 ). ...
... 1.09 ± 0.05 to 21.80 ± 1.09 mg/ g and UA: 0.39 ± 0.02 to 10.57 ± 0.53 mg/ g, re spec tively ( Table 4 ). Re cent in ves ti ga tions also sup ported the dis crep ancy in bioac tive com pounds in Swer tia species ( Srivastava et al., 2018 ). How ever, such vari a tion may be due to the ge o graph i cal sit u a tions, the na ture of plant ma te r ial, col lec tion time, ex trac tion meth ods used and dif fer ent sol vents used for ex trac tion. ...
The present study aimed to investigate phytochemical composition, antioxidant potential and quantification of anticancer, hepatoprotective and antidiabetic compounds using RP-UFLC from eight Swertia species. Extracts were obtained and evaluated for total phenolics; flavonoids as well as antioxidant properties were assessed by DPPH and FRAP assays. Identification and quantification of active components from different extracts obtained were performed by using RP-UFLC. Total phenolic content among the Swertia species ranged from 08.84 to 32.77 mg gallic acid equivalent (GAE)/g whereas total flavonoid content varied within range of 03.66–27.01 mg rutin equivalent (RE)/g plant material in different solvent extracts. DPPH activity, ranging from 20.67 to 91.85 percent radical scavenging activity (% RSA), whereas FRAP activity ranging from 00.98 to 04.34 mg Ascorbic acid Equivalent Antioxidant Capacity (AEAC)/g plant material in different solvent extracts. The varied range of content of active components was observed (Swertiamarin 3.18–130.53 mg/g, Betulinic Acid 0.63–1.93 mg/g, Oleanolic acid 1.09–21.80 mg/g and ursolic acid 0.39–10.57 mg/g). Hierarchical multivariate cluster analysis study divided eight species into seven clusters with two major clades with similarity ranging from 57.83 to 97.22% on the basis of TPC, TFC and antioxidant activity while dendrogram obtained from UFLC analyses had one major clade at 35.31% with six species separated from remaining two forming other clade with 35.31%–97.22% similarity. Depending on higher phytochemical content study represent S. chirayita to be the superior candidate among the all other species, contributing to higher DPPH and FRAP antioxidant activities with higher swertiamarin content.
