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... The remaining pancreatic β-cells underwent a burden to increase insulin levels to overcome the deficiency status, which progressively leads to induction of exhaustion and acceleration of β-cell apoptosis. Therefore, residual pancreatic β-cell is a novel pathway in the treatment of DM. [2] γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the central nervous system (CNS) of humans and other mammals, Figure 1. It synthesized by glutamate decarboxylase (GAD) from glutamate, which stored in the presynaptic vesicles. ...
