Fig 1 - uploaded by Dr. Muhammad Bilal Azmi
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Chemical structure of Cefixime.
Source publication
The objective of this study was to compare the antibacterial activity of standard and
different brands of Cefixime, against standard samples and clinical isolates of E. coli and S.
aureus collected from different hospitals. Standard samples and isolates of E. coli and S.
aureus were separately cultured in Mueller Hinton broth. After the bacteria...
Context in source publication
Context 1
... researches have reported Cefixime as a nontoxic and effective oral therapeutic especially in case of multidrug-resistance ( Memon et al., 1997). The chemical structure of Cefixime (Figure 1.) having molecular formula C 16 H 15 N 5 O 7 S 2 , with molecular weight 453.4, consists of the Cephem nucleus, in which a ring of -lactam is fused to a 6- membered di-hydro-thiazine ring (Gelone and O' Donnell, 2005). ...
Similar publications
The objective of this study was to compare the antibacterial activity of standard and different brands of Cefixime, against standard samples and clinical isolates of E. coli and S. aureus collected from different hospitals. Standard samples and isolates of E. coli and S. aureus were separately cultured in Mueller Hinton broth. After the bacterial i...
Citations
The development of highly efficient anti-bacterial wound dressings was carried out. For this purpose nanofibrous mats, hydrogels and films were synthesized from chitosan, poly(vinyl alcohol) and hydroxyapatite. The physical/chemical interactions of the synthesized materials were evaluated by FTIR. The morphology, structure; average diameter and pore size of the materials were investigated by scanning electron microscopy. The hydrogels showed a greater degree of swelling as compared to nanofibrous mats and films in phosphate buffer saline solution of pH 7.4. The in vitro drug release studies showed a burst release during the initial period of 4 h and then a sustained release profile was observed in the next upcoming 20 h. The lyophilized hydrogels showed a more slow release as compared to nanofibrous mats and films. Antibacterial potential of drug released solutions collected after 24 h of time interval was determined and all composite matrices showed good to moderate activity against Gram-positive and Gram-negative bacterial strains respectively. To determine the cytotoxicity, cell culture was performed for various cefixime loaded substrates by using neutral red dye uptake assay and all the matrices were found to be non-toxic.
