Fig 1 - uploaded by Lizy Roselet
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Chemical Structure of (a) Metformin hydrochloride (b) Pioglitazone hydrochloride and (c) Glimepiride.
Source publication
Metformin hydrochloride, Pioglitazone hydrochloride and Glimepiride are antidiabetic drugs used in the treatment of Type-2 diabetes. In this study, supramolecular complexes of these three drugs were synthesized and characterized using ¹H NMR spectroscopy. The possible encapsulation of the drugs inside the supramolecular complexes were depicted acco...
Context in source publication
Context 1
... of the drug, increase the therapeutic index, the efficacy/pharmacokinetics properties, and decrease the drug toxicity. In this study, 1 H NMR spectroscopy is employed to evaluate the supramolecular complexes of a-cyclodextrin with the three antidiabetic drugs namely Metformin hydrochloride,Pioglitazone hydrochloride and Glimepiride as shown in Fig. 1 and thereby used as a potential candidate in drug industry for desired pharmokinetic properties in ...
Citations
... The precipitate obtained after evaporation was dried and used for characterization. [7] Preparation of liquid inclusion complexes About 0.1650 g of stigmasterol was dissolved in 10 ml of ethanol and about 0.2918 g of α-CD was dissolved in 30 ml double-distilled water in a beaker. Liquid inclusion complexes were synthesized by varying the concentration of α-CD from 2 × 10 −3 M to 1 × 10 −3 M. The reactions were carried out at room temperature. ...
... Generally, when a guest molecule is encapsulated within the CD cavity, the hydrogen atoms present on the inner surface of the cavity (H-3 and H-5) will be shielded considerably [19] by the outer surface (H-1, H-2, H-4) and will be unaffected by the formation of inclusion complex. [7] The formation of inclusion complexes was studied by the changes in chemical shift caused by the guest and host to each other. The chemical shift change is defined as the difference in the chemical shift between the host and the host-guest complex. ...
