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Abstract
Background
Silicosis is caused by long-term exposure to silica dust. Crystal rhinestone workers can be exposed to high levels of silica dust and are at risk of silicosis.
Aims
To explore silicosis cases, silica dust exposure and control measures in a rhinestone factory in South China.
Methods
We extracted and analysed data on new silicos...
Contexts in source publication
Context 1
... performed our investigation in close cooperation with employees and employers based mainly on work tasks and dust prevention systems. We identified workplaces and activities with exposure to crystalline silica dust and designed a measurement strategy including different exposure activities (Table 1). We collected bulk samples from raw materials and fallout dust around the workplaces (Table 2). ...Context 2
... case was female. Ninetythree workers were diagnosed as stage Ⅰ and five workers as stage Ⅱ (Table 1) Figure 2). Workers were removed from the factory when their silicosis was suspected. ...Context 3
... mean age of first exposure to silica dust and the age of diagnosis were 22 and 33 years, respectively. The mean duration of exposure was 9.2 years (range 3-16) (Table 1). There were no significant differences between cases in stage Ⅰ and stage Ⅱ for age at first exposure and diagnosis, and duration of exposure (Table 1). ...Context 4
... mean duration of exposure was 9.2 years (range 3-16) (Table 1). There were no significant differences between cases in stage Ⅰ and stage Ⅱ for age at first exposure and diagnosis, and duration of exposure (Table 1). Identified cases had four job titles. ...Context 5
... (90%) were drilling workers and eight (8%) were polishing workers. There were no significant differences in the age of first exposure and diagnosis and duration of exposure between drilling and polishing workers (Table 1). Mixing at the batch house, feeding at the furnace unit, screening at the screening workshop, drilling at the drilling workshop and polishing at the polishing workshop were the main activities involving exposure to silica dust. ...Similar publications
The recent increase in silicosis cases in several countries casts doubt on dust control practices and their effectiveness in preventing respirable crystalline silica (RCS) exposure. Apart from silicosis, RCS may lead to other illnesses, health-related quality of life losses for workers and their families, and economic losses for companies. Thus, th...
People with silicosis may develop Erasmus syndrome, a condition characterized by the emergence of systemic sclerosis (SSc) after silica exposure. This case study emphasizes the significance of understanding the connection between occupational silica exposure, silicosis, and SSc. A 24‐year‐old male stonecutter got silicosis and a form of SSc followi...
Silicosis is a worldwide serious occupational disease that is caused by inhalation of silica crystals. However, little is known about the pathogenesis mechanism of silicosis. We performed single-cell sequencing in bronchoalveolar lavage fluid (BALF) from mine workers with silicosis and their co-workers who did not develop silicosis, and found that...
Purpose
The large burden of silicosis and tuberculosis (TB) in the South African mining industry, coupled with an under-resourcing of the compensation agencies responsible for certifying occupational lung disease, have resulted in serious backlogs. This work aimed to measure the efficiency gains from triaging occupational lung disease claims using...
Occupation is an important contributor to disparities in respiratory disease, affecting financial status, health-care access, and exposure to hazardous substances. Although occupation and associated exposures are included in the socioecological models, work exposures remain persistently absent from research on health inequities and their contributi...
Citations
... Это свидетельствует о высокой распространённости силикоза в современном мире. Наряду с традиционными отраслями, на сегодняшний день силикоз выявляется в новых сферах экономики, использующих современные технологии (например, изготовление зубных протезов, создание изделий из искусственного камня, получение денима, хрустальных страз и т. д.) [8][9][10]. ...
... В Классификациях 1950, 1958, 1968 и 1971 гг. представлен не только силикоз, но и другие виды пневмокониозов 9 . В отечественной Классификации пневмокониозов 1976 г. выделено шесть групп пневмокониозов, в том числе силикоз. ...
... Основным сырьём для их изготовления является кварцевый песок. Рабочие, производящие кристаллы горного хрусталя из кварца, подвергаются воздействию большого количества кварцевой пыли, которое в несколько раз превышает ПДК, если воздействие не контролируется должным образом [9]. ...
The authors presented an analysis of modern views on the risks of industrial exposure to silica. We touch upon the study of this problem abroad and in Russia. Researchers describe diseases associated with silica, both in traditional and new spheres of the economy. In the article, scientists have considered the relationship of exposure to silicon dioxide with the formation of autoimmune, сhronic obstructive pulmonary disease (COPD), kidney pathology, cardiovascular system, etc. The article tells about modern views on the mechanisms of development of pulmonary and extrapulmonary diseases associated with exposure to silicon dioxide. The authors have presented modern approaches to the prevention of multisystem risks associated with silica. Ethics. The study did not require the conclusion of the Ethics Committee.
... Dust-induced lung diseases are now regarded as one of the most common occupational diseases in humans. They are among the highest in terms of days of incapacity for work, disability, and death globally [4][5][6]. Pulmonary lesions due to prolonged exposure to dust particles of various fibrogenicity are also prominent in the structure of occupational morbidity in industrial regions of the Russian Federation. Furthermore, they cause extensive economic damages due to the loss or reduction in employees' working capacity [7]. ...
Background
The present study aims to determine the structure of morbidity in workers contacting industrial aerosols, assess the timeliness of diagnosing dust-induced lung disease in major industrial centers, and optimize diagnostics for early detection of occupational lung diseases in workers exposed to industrial dust hazards.
Methods
The study on the structure and incidence of occupational lung diseases was carried out in 2016–2020 based on the Moscow Centre for Occupational Pathology data. For a more in-depth clinical examination, 114 patients who were first admitted to the Occupational Pathology Centre with diagnosed pneumoconiosis (PC), chronic dust-induced bronchitis (CDB), and chronic obstructive pulmonary disease (COPD) were selected. All patients were subjected to a complex clinical-functional, spirographic, echocardiographic, fibroscopic, radiological, and CT lung examination, with subsequent analysis of the results obtained. The pathology caused by exposure to industrial aerosols within the studied period was first diagnosed in 344 workers. Most patients (64%) with newly detected pathologies were 50–59 years of age, with work experience in adverse conditions of 21–25 years (41%).
Results
The spirographic study of respiratory function revealed decreased forced vital capacity (FVC) indices in CDB and COPD patients. Changes in expiratory flow rates suggest occupational bronchitis at an earlier stage, whereas no apparent results were noted for the PC diagnosis. The results of fibroscopic examination in PC patients revealed atrophic processes of the bronchial mucosa in 46 (88.5%) of them, and 6 (11.5%) patients had a subtropic process. The results of echocardiographic examination allowed diagnosing pulmonary heart disease in 83 patients (72.8%). Of them, 42 (80.8%) were revealed in the group of patients with PC, 18 (50.0%) in the COB group, and 14 (53.8%) in the COPD group.
Conclusions
Computed tomography (CT) detected pathological changes in 52 patients, while the X-ray examination in six people showed no evidence of lung destruction. CT scan also showed that the number of patients with fibrotic PC (including silicosis) in the study groups increased. Timely clinical and functional examination (spirography, fibroscopy, echocardiography) of patients allows detecting PC (including silicosis), CDB, and COPD at an early stage of disease progression.
... Sedangkan di Amerika Serikat diperkirakan terdapat 2 juta orang dan 3 juta orang di Eropa terpajan debu silika di lingkungan kerjanya. [11][12][13] Telah diketahui bahwa pajanan silika yang terkait dengan pekerjaan berhubungan dengan meningkatnya mortalitas penyakit pernapasan akibat kerja. Banyak proses dan kegiatan industri seperti pekerjaan konstruksi, pertambangan, pembuatan terowongan, seni, kerajinan tangan dan patung, dan perhiasan yang melibatkan paparan inhalasi silika. ...
... Banyak proses dan kegiatan industri seperti pekerjaan konstruksi, pertambangan, pembuatan terowongan, seni, kerajinan tangan dan patung, dan perhiasan yang melibatkan paparan inhalasi silika. 11 Langkahlangkah untuk mengurangi inhalasi silika yang dilakukan berdasarkan struktural, lingkungan dan perbaikan teknis di tempat kerja dapat mengurangi angka kejadian penyakit tersebut. 14 Berdasarkan paparan tersebut, artikel ini memuat identifikasi bahaya paparan debu silika terhadap pekerja tambang. ...
Introduction: Pneumoconiosis is an occupational systemic disease that generally manifests as diffuse pulmonary fibrosis caused by inhalation of long-term silica dust in the production process, silicosis is one of them. Purpose: This article aims to identify the dangers of silica dust exposure to mine workers. Method: This study uses several literature studies through systematic review obtained from 36 reference sources. Some inclusion criteria that have been used are health research or related research articles published in the 2009-2019 range and research articles that contain topics on the identification of hazards of exposure to silica dust to mine workers. Results: Literature review results explain that miners have a high risk of silicosis due to silica exposure. Inhalation of this dust poses a danger because of its high silica crystal content if it settles in the lungs and can cause silicosis. Discussion: Crystal silica has also been classified as a human carcinogen. Silica crystals entering the lungs through three potential exposure pathways are identified namely external irradiation, inhalation of granite dust, and radon exposure. silica dust from granite mining also suggests using a filter mask, because the mask can reduce the amount of dust up to twice as much. Conclusion: In conclusion, occupational exposure to silica dust causes serious lung disease that is silicosis which is irreversible and so far there has been no effective treatment. Effective precautions are needed to reduce the risk factors for silica dust exposure.
... Sedangkan di Amerika Serikat diperkirakan terdapat 2 juta orang dan 3 juta orang di Eropa terpajan debu silika di lingkungan kerjanya. [11][12][13] Telah diketahui bahwa pajanan silika yang terkait dengan pekerjaan berhubungan dengan meningkatnya mortalitas penyakit pernapasan akibat kerja. Banyak proses dan kegiatan industri seperti pekerjaan konstruksi, pertambangan, pembuatan terowongan, seni, kerajinan tangan dan patung, dan perhiasan yang melibatkan paparan inhalasi silika. ...
... Banyak proses dan kegiatan industri seperti pekerjaan konstruksi, pertambangan, pembuatan terowongan, seni, kerajinan tangan dan patung, dan perhiasan yang melibatkan paparan inhalasi silika. 11 Langkahlangkah untuk mengurangi inhalasi silika yang dilakukan berdasarkan struktural, lingkungan dan perbaikan teknis di tempat kerja dapat mengurangi angka kejadian penyakit tersebut. 14 Berdasarkan paparan tersebut, artikel ini memuat identifikasi bahaya paparan debu silika terhadap pekerja tambang. ...
Introduction: Pneumoconiosis is an occupational systemic disease that generally manifests as diffuse pulmonary fibrosis caused by inhalation of long-term silica dust in the production process, silicosis is one of them. Purpose: This article aims to identify the dangers of silica dust exposure to mine workers. Method: This study uses several literature studies through systematic review obtained from 36 reference sources. Some inclusion criteria that have been used are health research or related research articles published in the 2009-2019 range and research articles that contain topics on the identification of hazards of exposure to silica dust to mine workers. Results: Literature review results explain that miners have a high risk of silicosis due to silica exposure. Inhalation of this dust poses a danger because of its high silica crystal content if it settles in the lungs and can cause silicosis. Discussion: Crystal silica has also been classified as a human carcinogen. Silica crystals entering the lungs through three potential exposure pathways are identified namely external irradiation, inhalation of granite dust, and radon exposure. silica dust from granite mining also suggests using a filter mask, because the mask can reduce the amount of dust up to twice as much. Conclusion: In conclusion, occupational exposure to silica dust causes serious lung disease that is silicosis which is irreversible and so far there has been no effective treatment. Effective precautions are needed to reduce the risk factors for silica dust exposure.
... A number of this issue's papers focus on occupational respiratory disease. Exposure to silica dust at work has been explored among construction workers in Sweden and rhinestone workers in South China with the absolute need for surveillance of exposure levels and having clear safety limits emphasized [1]. Consideration of smoking increasing risk in silica dust-exposed workers in Sweden is highlighted by Jonsson et al. [2]. ...
Purpose of review:
There is a considerable burden of silica-associated lung diseases in the developing world. This review summarizes the epidemiology of these diseases, especially silicosis and silico-tuberculosis, mitigative efforts and treatment, especially in the context of developing countries.
Recent findings:
In 2017, the highest incidence of silicosis was in China, India and Brazil among the developing countries. The prevalence of silicosis amongst exposed workers may vary from 4 to 55%; there is a risk of underestimation because of the 'healthy worker effect'. The permissible exposure limit for respirable silica adopted by governments in developing countries remains higher than the proposed 0.025 mg/m3. Silica exposure in informal or unorganized industries is challenging, as it falls outside statutory controls. Recent efforts on regulation and compensation by various governments in developing countries are encouraging but need proper implementation on the ground. Biomarkers such as club cell protein 16 and imaging methods such as computed tomography may offer earlier and easier detection of silicosis. Advanced silicosis remains incurable; novel treatments such as antifibrotics agents may be potentially effective.
Summary:
Silica-associated lung diseases are prevalent in developing countries. Efforts directed at preventing or minimizing exposure to respirable crystalline silica are required for mitigation.
Atractylenolide III (ATL-III) is a major active constituent of the natural plant Atractylodes rhizome. Our previous study has shown that ATL-III may alleviate alveolar macrophage apoptosis via the inhibition of the mammalian target of rapamycin (mTOR)-mediated autophagy of human silicosis. Therefore, we aimed to further explore the function of ATL-III in autophagy, apoptosis, and pulmonary fibrosis by establishing the ATL-III-intervened silicosis mouse model in this study. Meanwhile, we sought and then verified potential autophagy-related signaling pathways by matching differentially expressed genes (attained by RNA sequencing) and the autophagy database. In this study, RNA-sequencing results implied that the epidermal growth factor receptor, the crucial upstream activator of mTOR, was seen as a potential autophagy-regulatory molecule in the ATL-III-intervened silicosis mouse model. The finding of this study was that ATL-III might improve the disorder of autophagic degradation via the activation of epidermal growth factor receptor-mTOR signals in the pulmonary tissue of the silicosis mouse model. ATL-III also alleviated cell apoptosis and silicotic fibrosis. Overall, we supposed that ATL-III might be a potential protective medicine, which had a regulatory effect on autophagy, for the intervention of silicotic fibrosis. In the future, the therapeutic drugs for silicosis should be further focused on the development and application of such natural autophagy agents.
Along with the development of Chinese industry, dust control in the workplace has become an important issue. Dust not only endangers people's lives and occupational health, but also pollutes the environment, which hinders the construction and progress of clean and green production in China. This paper collected 1186 Chinese dust control literature from web core databases for a review, spanning 30 years. A bibliometric approach was employed to analyze and discuss the content of the dust control field, covering literature releases, authors, institutions, journal source, citations, and keyword co-occurrence. Furthermore, Bayesian networks(BNs) predicted future hot topics (FHTs) in the field. The results showed that there were three stages of literature publication; Nie Wen was the author with the most publications in the domain of dust control in China; Shandong University of Science and Technology was the authoritative institution in the field; According to the keyword co-occurrence analysis, the area mainly contains dust types, dust control methods, dust explosion, numerical simulation, occupational diseases and dust pollution; Finally, environmental pollution, numerical simulation and coal mine dust control were considered as the FHTs.
Background
Mounting evidence suggests that alternative splicing is one of the ways for cells to adapt to environmental stress insults. The aim of this study was firstly to examine the effect of silica on the alternative splicing of lung fibrosis–associated genes.
Methods
Microarray analysis was used to construct the alternative splicing profile. Functional experiments were conducted using Cell Counting Kit-8, cell cycle, apoptosis, and epithelial–mesenchymal transition (EMT) analyses. Alternative splicing variants were verified by quantitative real-time polymerase chain reaction (qRT-PCR) polymerase chain reaction method.
Results
A total of 1850 genes that have alternative splices in response to silica insult were identified. PCDHB11, MALAT1, MT2A, RP11-126D17.1, and RP11-415I12.2 are the top 5 upregulated genes with occurrence of alternative splice, whereas NDE1, RNPEPL1, TREML2, CSF2RB, and PRKCSH are the top 5 downregulated genes with occurrence of alternative splice. Bioinformatic analysis showed these genes with the occurrence of alternative splice mainly are associated with EMT pathway, N-Glycan biosynthesis, and leukocyte transendothelial migration. Further study indicated that PRKCSH-2 knockdown promotes A549 cell proliferation potential by partially promoting EMT signals.
Conclusions
Significant changes in alternative splicing of silicosis-associated genes occur in patients with silicosis in silica conditions. Our study provides basic founding for further investigation into the detail molecular mechanisms underlying silica-induced silicosis.
