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Characteristics of 58 patients with allergic contact dermatitis due to nitrofurazone
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Introduction:
Allergic contact dermatitis (ACD) is a form of dermatitis due to type 4 hypersensitivity reaction that occurs when the skin comes into contacts with the topical product. Topical nitrofurazone is a widely used antimicrobial drug in our country which is well known to cause ACD.
Aim:
In this study, ACD cases with different clinical fe...
Context in source publication
Citations
... The ointment form of nitrofurazone comprises 0.2% nitrofurazone and the vehicles polyethylene glycol (PEG) 300, PEG 1000, and PEG 4000. Nitrofurazone sensitization is widely reported in the literature [18]. Because of the high incidence of allergic reactions, the use of nitrofurazone has been largely discontinued in Western countries [19]. ...
Background: Both the skin and neuronal systems originate from the ectoderm. In patients hospitalized for neurosurgery, their skin may be affected by genetic and environmental factors.
Objective: This study researched disease relationships by evaluating the profile of hospitalized neurosurgery patients who consulted with dermatology in a tertiary clinic (Neurosurgery Clinic, Ankara Training and Research Hospital, Ankara).
Methods: This study included hospitalized neurosurgery patients who consulted with dermatology. Age, gender, type of hospitalization, neurosurgical diseases, and dermatology diseases were selected as study variables. The medical health records of the patients were retrospectively scanned and analyzed.
Results: A total of 172 consultations were analyzed. The mean age of patients was 44.7 years old ranging from 1 year to 99 years old. The percentage of male patients was 54.7%; 25.5% of the patients were hospitalized for cerebral vascular diseases, 30.2% for spinal diseases, 22.1% for tumors, 12.2% for infections, and 1.2% for other neurosurgical diseases. The most commonly diagnosed dermatological disease in patients was drug eruptions (18.6%), followed by seborrheic dermatitis (16.2%) and contact dermatitis (14.5%).
Conclusion: According to this study, the most commonly diagnosed dermatological diseases in neurosurgery inpatients were drug eruption, contact dermatitis, and seborrheic dermatitis. The results of this study may be helpful in terms of neurosurgical training planning and treatment management.
... None of the dermatologists preferred this molecule, while it was the fourth most preferred antibiotic, chosen by 27.6% of non-dermatologists. Allergic contact dermatitis due to nitrofurazone is a well-known complication that dermatologists are familiar with it, having treated it many times throughout their careers, and it is well-described in the literature [4,9]. However, our findings indicate that this experience and literature knowledge are not shared by non-dermatologist physicians. ...
Objective: Regardless of their specialty, physicians frequently encounter dermatological conditions. We aimed to determine the topical medication choices of physicians for various dermatoses and to identify differences in preferences between dermatologists and non-dermatologist physicians. Methods: Using an online survey, physicians were asked to select three preferred topical antibiotics/antiseptics, antifungals, and corticosteroids when treating a pyoderma, dermatophytosis, or a dermatosis necessitating topical corticosteroid therapy. Statistical analysis was performed using Statistical Package for the Social Sciences v.27. Results: Among 358 physicians, 24.0% were dermatologists, and 76.0% were non-dermatologist physicians. The mean age was 38.40, and the average duration of medical practice was 14.04 years. The most frequently chosen topical antibacterials were fusidic acid (74.3%) and mupirocin (65.9%); topical antifungals were isoconazole nitrate + diflucortolone valerate (56.4%), tioconazole (27.7%), and naftifine (25.1%); and topical corticosteroids were clobetasol propionate (38.5%), methylprednisolone aceponate (36.6%), and mometasone furoate (34.6%). Dermatologists used nitrofurazone and izokonazol nitrate + diflucortolone valerate less frequently compared to non-dermatologists (0% vs. 27.6% and 8.1% vs. 71.7%, respectively; p-values <0.001). Family physicians/general practitioners constituted the largest group selecting clobetasol propionate (28.3%). Conclusion: Physicians in our country predominantly choose fusidic acid and mupirocin as topical antibiotics, aligning with existing literature. However, nitrofurazone, causing contact dermatitis, and corticosteroid-containing antifungals with the potential for complications due to inappropriate use are frequently preferred by non-dermatologist physicians but not by dermatologists. The bold choice of clobetasol propionate, an ultrapotent topical corticosteroid, by family physicians/general practitioners is an important issue to address during medical education and post-graduation.
... 16,17 Exposure to these antibiotics for a long time may cause several side effects such as nausea, vomiting, headache, loss of appetite and dizziness. 18,19 Thereafter, it is necessary to develop a suitable method to prevent the environmental pollutions caused by these antibiotics. ...
The solvothermal reaction of ZrCl4 with benzo[1,2-b:4,5-b’]dithiophene-2,6-dicarboxylic acid linker molecule in presence of trifluoro acetic acid modulator afforded the UiO-66 type of metal organic framework (MOF) (IITG-5, IITG = Indian...
... This ointment is widely used to treat various types of superficial wounds, including burns. However, complications such as localized and limited drug absorption in the wound, drug resistance, allergic contact dermatitis, edema, erythema, itching, and blisters have been reported (4,5). Due to these complications, Bajaj and Gupta reported that Nitrofurazone was the most sensitizing agent in 390 patients and that 36.2% of the patients had a positive reaction due to Nitrofurazone(4). ...
Background & Aim: Routine treatment of burn injuries is dressing with Nitrofurazone ointment. It has several complications including sensitivity. Aloe vera is a traditional treatment for wound healing. This study aimed to compare the effectiveness of Aloe Vera gel with Nitrofurazone ointment in the healing of superficial partial-thickness burns.
Methods & Materials: The present study was a split body controlled clinical trial which was carried out on 30 patients with superficial partial-thickness burns. The study was conducted in the Shafa Hospital in Kerman, Iran in 2016. The sample was recruited from patients who had at least two burns, each burn on an alternate side of the body. Samples were allocated to two groups that received Aloe Vera gel or 2% Nitrofurazone ointment on their burns. Bates-Jensen Wound assessment tool was used to evaluate the healing of burns. Statistical analysis was conducted by SPSS-16 and using the repeated measure ANOVA.
Results: The repeated measure ANOVA showed that there was a significant change in the score of BWAT in all areas during the intervention period ( p=0.001), but The trend of healing in the two groups during the intervention period was not significantly different( p=0.098).
Conclusion: Based on this study it looks like Aloe vera gel is as effective as 2% Nitrofurazon ointment in healing wounds.
... It has been used for the treatment of various infections in hospitals, pyodermic infections, and cutaneous ulcers. [22] So patch test positivity to this antigen is consistent with our study population. ...
Introduction: Health care workers form an important occupational group with a high risk of hand eczema. All health care professionals are exposed to a variety of allergens and irritants which can cause hand dermatitis, resulting in significant morbidity. Aims and Objectives: To assess the clinical profile of hand eczema in hospital employees, to perform patch test in relevant cases and to find out the most common sensitizers in them. Materials and Methods: This was a cross‑sectional, hospital‑based study in which the staff was screened for features of hand eczema and patch testing was done in the suspected cases of allergic contact dermatitis. Results: Out of 340 employees screened, 46 employees (13.5%) suffered from hand eczema. The most common type was wear and tear dermatitis accounting for 17 (36.9%) cases, followed by discoid eczema, pompholyx, focal palmar peeling, finger‑tip eczema, hyperkeratotic eczema, ring eczema, and unspecified types.
Patch testing was positive in 15 (32.6%) cases. The most common allergen was paraphenylene diamine, followed by fragrance mix, nitrofurazone, mercaptobenzothiazole, potassium bichromate, black rubber mix, and thiuram mix. A statistically significant association (0.001) was found with an underlying history of atopy. Conclusion: Hand eczema is a commonly encountered dermatological complaint in many hospital employees. Proper counseling, work, up, patch testing, and treatment can mitigate the symptoms in such employees.
... However, complications such as localized and limited drug absorption in the wound, drug resistance, allergic dermatitis, burning, edema, erythema, renal impairment, thrombocytopenia, itching, and blisters have been reported. Due to these complications, researches are conducting to nd less complicated and effective alternatives for the treatment of burns (13)(14)(15)(16)(17)(18)(19). Aloe Vera is a clump-forming, perennial succulent with basal rosettes of tapering thick leaves. ...
Background: Burn injuries are one of the most common sources of trauma globally that comprise a significant drain on long-term personal and healthcare cost Large surface area burn wounds are difficult to manage and may result in significant physiologic and psychological sequelae. The aim of this study was to compare the effectiveness of Aloe Vera gel with 2%Nitrofurazone ointment in the healing of superficial partial thickness burns wounds.
Methods: The present study was a split body controlled, randomized clinical trial. The sample was recruited from patients with superficial partial thickness burns wound who were prescribed to treat with 2% Nitrofurazone ointment. Thirty patients with at least two burn, each burn on an alternate side of the body, entered the study — samples allocated to two area which received Aloe Vera gel or 2% Nitrofurazone ointment on their burns. Bates-Jensen Wound. assessment tool (BWAT) was used to evaluate the healing of burns. the epithelialization parameter and sum score Bates-Jensen tools evaluated before, one, two and three weeks after the beginning of treatment.
Results: The mean ± SD of epithelialization parameter in Aloe Vera area were 5.0±00.00, 4.0±46.57, 3.0±50.57, 2.0±56.62. The mean ± SD of epithelialization parameter in 2% Nitrofurazone ointment area were 5.0±00.00, 4.0±66.54, 3.0±76.50, 3.0±03.61.and The mean ± SD of BWAT scores in Aloe Vera area were 30.32 ± 3.28, 27.33 ± 3.38, 21.33 ± 3.13, 16.12 ± 2.16 respectively (F(2, 65.07) =440.00, p=0.001). The mean ± SD of BWAT scores in 2% Nitrofurazone ointment area were 30.51 ± 3.79, 28.45 ± 3.49, 23.36 ± 2.89, 19.23 ± 2.11 ( F(1, 52.00) =228.00, p=0.001).
Conclusions: There is a significant difference in epithelialization parameter and (BWAT) scores between intervention and control area. Based on this study it looks like that aloe vera gel could promoted epithelialization and wound closure more effectively than 2% Nitrofurazone ointment
The integumentary system consists of the skin, hair, mammary glands, adnexal glands, and toenails. Hair quality may be modified by such environmental factors as day length, temperature, elevation, and general nutrition, but the dominant factor in determining quality is heredity. Parasitic diseases of the skin include mange, pediculosis, and myiasis. Fungal dermatitis is uncommon in camelids, but can occur in both South American Camelids (SACs) and Old World Camels. Overgrowth of the toenail is the most common disorder of the SACs foot. Camelid mastitis occurs in the same forms as seen in dairy cattle, namely, subclinical, peracute, acute and chronic. The goals of the proliferative phase are to form granulation tissue and an epithelial covering over the wound. There is a dearth of veterinary research regarding wound healing in camelids, yet a plethora of literature involving research on small laboratory animals and humans exist.
Furacin is an ointment for topical administration containing the anti-
biotic nitrofurazone (0.2%) and a mixture of polyethylene glycol
(PEG) polymers (PEG 300, PEG 1500, PEG 4000) that act as a vehicle
to facilitate its penetration through the skin.
Our case highlights the importance of performing the correct
PT with the components and excipients of topical medications.
Sensitization to the active principle does not exclude a possible cosensitization to the other components; cross-reactivity or sensi-
tization to other excipients present in drugs and cosmetics must
be ruled out.
