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Changes in RQLQ results following the third and fourth herbal plaster (hp) treatments in Ph-negative patients
Source publication
Background
Allergic rhinitis is regarded as an imbalanced Th1/Th2 cell-mediated response. The present study used microarray analysis to compare gene expression levels between allergic rhinitis patients before and after a series of acupoint herbal plaster applications. Methods
In this experimental pilot study, volunteers experiencing sneezing, runny...
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Abstract Background Allergic rhinitis is a common respiratory disease. Acupuncture is used to treat it in traditional Chinese medicine, and generally, the L120, ST2 and ST36 acupoints are selected in clinical practice. We report a new method of acupuncture at the sphenopalatine acupoint (SPA) for treatment of persistent allergic rhinitis (PAR). The...
Citations
... Akupunktur telah lama digunakan di TCM untuk mengobati RA dan penelitian tentang pengobatan ini telah menunjukkan hasil yang beragam. Namun penelitian yang paling sering dilakukan hanya menunjukkan manfaat klinis akupunktur terhadap RA secara sederhana (Choi et al., 2013;Shiue et al., 2016). ...
Abstrak Rhinitis alergika (RA) adalah salah satu gangguan kesehatan sebagai kelainan pada hidung disertai gejala bersin-bersin, hidung berair, rasa gatal dan tersumbat pada hidung setelah mukosa hidung terpapar alergen yang diperantarai oleh imunoglobulin E (IgE). Banyak penelitian yang membuktikan dampak akupunktur pada sistem imun. Penelitian ini merupakan sistematic review dan meta-analisis, dengan PICO, yaitu Population: pasien rhinitis alergika. Intervention: terapi akupunktur. Comparison: sham/placebo akupunktur. Outcome: kualitas hidup. Artikel yang digunakan dalam penelitian ini diperoleh dari beberapa database antara lain Google Scholar, MEDLINE/PubMed, Science Direct, Hindawi, Europe PMC dan Springer Link. Artikel-artikel ini dikumpulkan selama 1 bulan. Kata kunci untuk mencari artikel adalah sebagai berikut: “acupuncture for allergic rhinitis†OR “acupuncture for seasonal allergic rhinitis†OR “acupuncture for parenial allergic rhinitis†AND “quality of life†AND “randomized controlled trialâ€. Artikel yang termasuk dalam penelitian ini adalah artikel full text dengan desain studi randomized controlled trial (RCT). Kualitas hidup diukur dengan menggunakan Rhinitis Quality of Life Quissioner (RQLQ). Meta analisis ditulis menggunakan PRISMA flow diagram dan dianalisis dengan menggunakan aplikasi Review Manager 5.4. menunjukkan terdapat pengaruh terapi akupunktur terhadap kualitas hidup pasien rhinitis alergika. Akupunktur mampu menurunkan skor RQLQ (meningkatkan kualitas hidup), meskipun secara statistik tidak signifikan. Pasien rhinitis alergika yang mendapatkan akupunktur rata-rata memiliki kualitas hidup dengan skor RQLQ 0.17 unit lebih baik daripada mendapatkan sham akupunktur/akupunktur palsu (SMD = -0.17; CI 95% = -0,40 hingga 0.05; p = 0.120). Terdapat pengaruh akupunktur terhadap kualitas hidup pasien rhinitis alergika. Kata Kunci: Acupuncture, Allergic rhinitis, Kualitas Hidup, RQLQ, Randomized Controlled Trial, Meta-analisis
... Also with regard to the Th1-pathway, controversial results can be found in the literature. Whereas gene expression profiles in patients with AR before and after acupoint herbal plaster have shown an up-regulation of the Interferon (IFN)signalling [28], the concentration of IFN-γ remained constant throughout acupuncture treatment in humans with AR in other trials [19,20,27]. ...
Purpose
Numerous studies have demonstrated effectiveness for acupuncture in the treatment of seasonal allergic rhinitis (SAR). However, the underlying mechanism remains still unclear.
Methods
29 SAR patients were recruited from a large randomized, controlled trial investigating the efficacy of acupuncture in SAR. 16 patients were treated by acupuncture plus rescue medication (RM, cetirizine), 6 patients received sham acupuncture plus RM and 8 patients RM alone over 8 weeks. Patients were blinded to the allocation to real or sham acupuncture. At baseline and different time-points during intervention, plasma and nasal concentration of mediators of various biological functions were determined in addition to validated disease-specific questionnaires.
Results
The concentration of biomarkers related to the Th1-, Th2-, and Treg-cluster was not changed in patients who received acupuncture, in neither plasma nor nasal fluid. However, with respect to eotaxin and some unspecific pro-inflammatory cytokines (IL-1b, IL-8, IP-10, MIP-1b, MCP-1), acupuncture led to a, partially significantly, lower nasal concentration than sham acupuncture or RM. Furthermore, the nasal symptom score was significantly reduced in patients only after real acupuncture.
Conclusion
In SAR, acupuncture reduces the intranasal unspecific inflammation, but does not seem to act immunologically on the Th1–Th2-imbalance.
... However, undesirable side effects have been reported with the long-term use of these drugs, which include drug resistance and drug dependence. Therefore, drugs obtained from plant sources, which have fewer side effects and better safety profiles, have attracted increased attention in recent years [10][11][12]. Black cumin (Nigella sativa L.) has been known for its antioxidant, anti-inflammatory, antibacterial, antifungal, antidiabetic, analgesic, anticancer, and immunomodulatory effects [13][14][15]. It has been widely used as a traditional medicine for the treatment of many inflammatory and allergic diseases in countries belonging to the African, Asian, Arab, and Indian subcontinent regions [16]. ...
Background
A formulation of black cumin ( Nigella sativa L.), licorice ( Glycyrrhiza glabra L.), anise ( Pimpinella anisum L.) and tea ( Camellia sinensis (L.) Kuntze) (denoted BLAB tea) is traditionally used to relief allergy reaction including allergic rhinitis. However, little is known about its underlining mechanism of anti-allergic effects.
Methods
To investigate the anti-allergenic mechanism of BLAB tea, we treated ovalbumin (OVA)-induced allergic rhinitis (AR) model of mice with BLAB tea, and elucidated its possible mechanism of action. Mice in the control group were treated with phosphate-buffered saline only. Subsequently, the infiltration of different inflammatory cells was measured. In addition, histopathological changes in the nasal mucosa, and the levels of allergen-specific cytokines and OVA-specific immunoglobulins were measured.
Results
The aqueous extract of BLAB significantly alleviated the nasal symptoms and reduced the accumulation of inflammatory cells in the nasal mucosa and nasal lavage fluid of AR model of mice.
Conclusion
The aqueous extract of BLAB induced the production of Th1 and Treg cytokines and inhibited the release of Th2 cytokines and histamine in nasal mucosa and serum of mice while decreasing the serum levels of OVA-specific IgE, IgG1, and IgG2a. These results suggest the potential of the aqueous extract of BLAB as a treatment option for allergic diseases.
... AHP, by contrast, became a relatively appropriate choice and was easier for patients to accept. As one type of TCM method, herbal plaster was applied with a drug applicator using the mature technique, stimulating the skin at specific acupoints [18]. Our team previously completed the 36 cases clinical observation of AHP for the prevention and treatment of PONV after surgery [19]. ...
Background
Postoperative nausea and vomiting (PONV) are common in posterior lumbar intervertebral fusion (PLIF) patients undergoing general anesthesia. The previous clinical observation has shown that a traditional acupoint herbal plaster (AHP) is beneficial to patients with PONV. This trial aims to assess the effect of the AHP for the prevention and treatment of PONV after PLIF in patients with general anesthesia.
Methods
A multicenter, parallel, randomized controlled trial (RCT) will be conducted. A total of 166 participants will be randomized to either a treatment group receiving an AHP or a control groups receiving an acupoint placebo plaster (APP) in a 1:1 ratio. The primary outcomes are the first occurrence and frequency of nausea and vomiting. The secondary outcomes include the severity grading of nausea and vomiting using a visual analog scale (VAS) measurement system, quality of life, and serological indicators. The safety evaluation is mainly about adverse events and skin reactions’ observation. Assessments will be carried out at the baseline, day 1, and day 2 (the end of the intervention). The central randomization system in the clinical trial ( http://124.205.181.142:8082/xwtf/ ) will be used to conduct random allocation.
Discussion
This scientific methodology design of the trial is expected to provide clinical evidence to support the AHP for the prevention and treatment of PONV.
Trial registration
This study is retrospectively registered with the Chinese Clinical Trial Registry ( http://www.chictr.org.cn ) on 19 April 2018. ID: ChiCTR1800015768.
... [18] Wormwood has the effect of warming meridians and dispelling cold, and can dispel dampness and relieve itching used externally. [19] According to modern mechanism studies, moxibustion therapy has antiallergic effects and can treat a variety of diseases related to allergic reactions, including urticaria, allergic rhinitis, irritable bowel syndrome, [20][21][22] etc. Moxibustion therapy also has antibacterial effects, which can inhibit various bacteria such as gram-negative bacteria, Streptococcus beta, This paper is funded by the Innovative research team of high-level local universities in Shanghai-Clinical and basic research on the prevention and treatment of some inflammatory diseases by integrative medicine. ...
Background:
Chronic spontaneous urticaria (CSU) is a common disease in clinical, and often recrudescent. However, sometimes Western medicine treatments such as antihistamines cannot completely control the symptoms of CSU; therefore, more effective and optimized treatments are needed. Numerous studies have confirmed that moxibustion therapy is effective in treating CSU. Given that no relevant systematic reviews and meta-analysis have been carried out, we set out to prove the effect of moxibustion therapy for CSU.
Methods:
This protocol will be conducted based on the PRISMA-P guidelines and comply with the recommendations of the Cochrane Collaboration Handbook for Systematic Reviews. We plan to search the subsequent databases: PubMed, Web of Science, EMBASE.com and Cochrane Library, China National Knowledge Infrastructure, WanFang Database, Chinese Science Journal Database, and China Biomedical Literature Database. The studies will be screened under the eligibility criterion. The quality of the studies will be assessed based on the Cochrane risk bias tool. Ultimately, Review Manager 5.3 will be used for statistical analysis.
Results:
This research will comprehensively evaluate the effectiveness of moxibustion therapy for CSU, and provide a more reasonable and effective treatment plan for CUS.
Conclusion:
This research will bring new evidence for the efficacy of moxibustion therapy in the treatment of CSU and provide a basis for future clinical applications.
Inplasy registration number:
INPLASY2020100045.
... Например, исследовательский коллектив под руководством H. Shiue и соавт. (2016) [64] показал, что терапия травяными пластырями, применяемыми с помощью техники моксибустион, ассоциирована с небольшим, но статистически значимым улучшением баллов качества жизни по RQLQ (p = 0,04). ...
The high prevalence of allergic rhinitis in a population, the link between this disease and asthma, and a significantly higher economic burden of the disease, causing a negative impact on the patients quality of life, have resulted in increased attention to the problem of allergic rhinitis at the global level. Nowadays optimal allergic rhinitis treatment and management include disease control, consisting of assessing the level of disease control and selecting a treatment scheme based on this assessment. Current studies are focused on the development of questionnaires and testing systems for assessing the level of disease control, especially given the absence of a standardized control assessment procedure tool. Studies also address the possibility of using the indicators of quality of life to measure the level of disease control. The present review deals with the issue of understanding of using this parameter to measure the effectiveness of pharmacotherapy of different groups of patients with allergic rhinitis. The review includes randomized clinical trials covering the period 20102019 including the following keywords: Rhinitis Quality of Life, Allergic Rhinitis Quality of Life, Allergic Rhinitis Questionnaire, RQLQ. In total, 4.407 publications were identified and analyzed, only 60 publications were selected for comparative analysis after a second review. According to the results, in general, it can be concluded that the indicator of the quality of life allows us to identify the advantages of pharmacotherapeutic regimens in the long term (for example, allergen-specific immunotherapy, alternative therapy). Moreover, it demonstrates a correlation with objectivistic indicators in randomized clinical trials of standard treatment. It is still necessary, however, to address the question of whether it would be possible to use the assessment of the quality of life as a part of allergic rhinitis treatment in everyday clinical practice to select a group of drugs, their dosages, and correct regimes in dynamics. Using the indicator of the quality of life for managing patients with allergic rhinitis in Russia requires tremendous work in terms of cross-cultural adaptation of questionnaires and large-scale population-based pharmacoepidemiological studies.
... In TCM, disease is understood to originate from an imbalance or poor flow of qi. Acupuncture has long been used in TCM to treat AR, and studies of this treatment have shown mixed results, with the most rigorous studies showing only modest clinical benefits [21][22][23][24]. The 2015 revision of the American Academy of Otolaryngology-Head and Neck Surgery clinical practice guidelines for AR cites a low level of confidence in the evidence to support acupuncture as a treatment option. ...
Background:
Many studies have shown the potential therapeutic effect of acupuncture on allergic rhinitis. Most of these studies were limited by low-quality evidence. Preliminary experiments showed that the use of acupuncture at three nasal acupoints plus acupoint application (AAP) achieves a more persistent effect in the treatment of perennial allergic rhinitis than acupuncture alone. In this study, a multicenter, single-blind, randomized controlled trial will be performed, in which acupuncture at nonmeridian acupoints and sham AAP will be used as the control group to evaluate the effect of AAP through long-term observation.
Methods:
The trial is designed on the basis of the Consolidated Standards of Reporting Trials 2010 guidelines and Standards for Reporting Interventions in Controlled Trials of Acupuncture. A total of 120 participants with perennial allergic rhinitis will be randomly assigned to a treatment or control group. A specially appointed investigator will be in charge of randomization. The participants in the treatment group will be treated with acupuncture at EX-HN3, LI20, and EX-HN8 thrice per week for a total of 12 sessions. In addition, they will undergo AAP at DU14, BL13, EX-BI, and RN22. The participants in the control group will be treated with sham AAP. The primary outcome will be the change in the Total Nasal Symptom Score from baseline to the completion of 4-week treatment. Secondary outcomes include changes in visual analog scale and total non-nasal symptom scores from baseline to the second and fourth weeks of treatment, as well as 1, 3, and 6 months after the completion of treatment. Peripheral blood IL-4, IL-5, IL-6, IL-8, and IL-10 levels will be measured, and any side effects related to treatment will be observed and recorded.
Discussion:
It is expected that this randomized clinical trial will provide evidence to determine the effects of AAP compared with acupuncture at nonmeridian acupoints and sham AAP, particularly the long-term effect. These findings will help improve the clinical application of this technique.
Trial registration:
Acupuncture-Moxibustion Clinical Trial Registry AMCTR-ICR-18000179. Registered on 12 April 2018.
... 13 HAT for allergic rhinitis and asthma can improve self-reported health and social function, and it can also reduce the frequency of use of western medicine. [14][15][16] Therefore, HAT is a convenient, noninvasive technology that is worth developing and provides self-regulation within treatment parameters. ...
Objective
Hypotension during hemodialysis (HD) is the most common complication that negatively affects the quality of life of patients. The objective of the current study was to evaluate the preliminary efficacy and safety of herbal acupoint therapy (HAT) for intradialytic hypotension (IDH).
Methods
A randomized, placebo-controlled trial was performed in 32 HD patients to determine whether HAT was more effective than a sham treatment for the treatment of IDH. The outcomes were frequency of IDH episodes and number of nursing interventions during HD sessions, pre- and post-dialysis BP, subjective change in fatigue as measured by the Visual Analogue Scale (VAS), and recovery time from fatigue after dialysis at the 0th and 4th week. Data analyses were performed using per-protocol population.
Results
In all, 27 patients (84%) completed the entire study. At the end of the intervention, the patients in the HAT group were found to have a significantly lower frequency of IDH episodes, fewer nursing interventions, a lower intervention failure rate, and earlier discontinuation of dialysis than those in the sham group (p < .05). The improvement in degree of fatigue (p = .001) was greater and recovery time from fatigue after dialysis (p = .03) was shorter in the group treated with HAT than in the sham group. HAT was safe, with 2 withdrawal cases due to local erythema caused by the patch.
Conclusions
HAT appears to be safe and efficacious for improving IDH-related symptoms and intervention in HD patients. Larger studies are needed to confirm the benefit of this technique for IDH.
... The AHP therapy is a type of transdermal drug delivery. To date, the mechanisms behind this therapy remain undefined; several studies have indicated that AHP took part in the immunological regulation when treating allergic rhinitis and asthma [14,15]. With an increasing understanding of the skin as an immune system, the intradermal route has emerged as an ideal route to administer vaccines and immunomodulators [16]. ...
Objective
To investigate the site of action of sinapine thiocyanate (ST), following acupoint herbal patching (AHP).
Methods
Twenty Wistar rats were randomized into five groups (groups A, B, C, D, and E), and all groups received the same AHP in vivo. Skin samples were excised at 2 h, 4 h, 6 h, 10 h, and 26 h after AHP administration from group A to group E separately and the concentrations of ST in the skin were determined using a liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) method. A pharmacokinetic profile of ST following AHP was performed at the same time in a group of five Wistar rats to detect plasma levels at the same time intervals.
Results
The mean ± SD ST concentrations (ng/ml) at 2 h (group A), 4 h (group B), 6 h (group C), 10 h (group D), and 26 h (group E) after AHP administration were 250.01 ± 61.99, 61.01 ± 30.41, 40.12 ± 26.94, 78.66 ± 59.43, and 19.55 ± 18.95, respectively. No ST was detected in rats' plasma samples at the same time points.
Conclusions
The site of action of ST following AHP is in the skin.
... However, the prolonged use of those methods results in a variety of undesirable side effects, including anaphylactic risk and prolonged duration. Consequently, natural products characterized as being more effective and safe, have attracted more attention [7]. EGCG is the major polyphenolic constituent of green tea catechins [8]. ...
... The early phase can induce sneezing, nasal itching, runny and congested nasal passages, and other symptoms. The late phase con- tributes to patient fatigue, malaise, irritability, and other symptoms [7]. Our data are a clear indication that the number of occurrences of nasal rubbing and of sneezing increased after OVA stimulation, which is a hallmark of allergic rhinitis. ...
... Overall, accumulating evidence indicates that the above-mentioned mediators act as a primary contributory role in the pathogenesis of AR. Consistent with previous studies [7,36,52,53], our data showed that OVA stimulation increased the level of histamine, IL-1β, IL-4, IL-6, and IgE. Thereby, a variety of anti-allergic drugs alleviate the symptoms of allergic rhinitis by lowering the level of aforementioned mediators [54]. ...
Currently, a variety of studies have demonstrated that green tea has anti-allergic properties, and the major polyphenolic compound, epigallocatechin gallate (EGCG), plays a significant role. Some research indicates that EGCG reduces the production and expression of allergy-related substances. Therefore, EGCG has a potential effect of reducing allergic rhinitis (AR). In this study, the effect of EGCG on allergic rhinitis in an ovalbumin (OVA)-induced mouse model was investigated. After administration of EGCG, the number of sneezes and the occurrence of nasal rubbing were significantly decreased, the concentrations of immunoglobulin E (IgE) and histamine were suppressed in AR mouse serum, the levels of interleukin (IL)-1β, IL-4, and IL-6 were reduced in AR mice nasal lavage fluid (NLF), and the nasal mucosa mRNA and protein expression of cyclooxygenase 2 (COX-2), IL-1β, IL-4, and IL-6 were inhibited. The data indicate that EGCG has a beneficial effect of reducing allergic rhinitis.
