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Change in average compressive strength of the cements tested as a function of their composition: (a) −30% liquid part (l.p.), (b) −15% l.p., (c) correct ratio, (d) +10% l.p., (e) +20% l.p., (f) +40% l.p. A summary of all the results obtained from the tests is shown in the comparison of manufacturing inaccuracy from seasoning time in Figure 5a,b.
Source publication
The paper presents the results of experimental strength tests of specimens made of two commercially available bone cements subjected to compression, that is a typical variant of load of this material during use in the human body, after it has been used for implantation of prostheses or supplementation of bone defects. One of the factors analysed in...
Contexts in source publication
Context 1
... to the test plan and the previously mentioned ISO standard, the results obtained were averaged and, taking into account the standard deviation, are pre-sented in the following diagrams. Figure 4 shows the compression strength results grouped according to the inaccuracy of the liquid component dosage measured with increasing seasoning time. The data clearly show that the average compressive strength decreases with seasoning time. ...
Context 2
... to the test plan and the previously mentioned ISO standard, the results obtained were averaged and, taking into account the standard deviation, are presented in the following diagrams. Figure 4 shows the compression strength results grouped according to the inaccuracy of the liquid component dosage measured with increasing seasoning time. The data clearly show that the average compressive strength decreases with seasoning time. ...
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Citations
... Figure 3 presents the percentage breakdown of fixation methods found in the Swedish, Australian, British and American endoprosthesis registries. Bone cement, or polymethylmethacrylate (PMMA), has been used in surgical fixation of protheses over the last 60 years [59][60][61][62]. The primary function of bone cement is to transfer forces from the bone to the prosthesis [63,64]. ...
Knee osteoarthritis (OA) is one of the leading causes of disability around the globe. Osteoarthritis is mainly considered a disease affecting the elderly. However, more and more studies show that sports overuse, obesity, or congenital disorders can initiate a pathologic cascade that leads to OA changes in the younger population. Nevertheless, OA mostly affects the elderly, and with increasing life expectancy, the disease will develop in more and more individuals. To date, the golden standard in the treatment of the end-stage of the disease is total joint replacement (TJR), which restores painless knee motion and function. One of the weakest elements in TJR is its bonding with the bone, which can be achieved by bonding material, such as poly methyl-methacrylate (PMMA), or by cementless fixation supported by bone ingrowth onto the endoprosthesis surface. Each technique has its advantages; however, the most important factor is the revision rate and survivor time. In the past, numerous articles were published regarding TJR revision rate, but no consensus has been established yet. In this review, we focused on a comparison of cemented and cementless total knee replacement surgeries. We introduced PICO rules, including population, intervention, comparison and outcomes of TJR in a PubMed search. We identified 783 articles published between 2010 and 2023, out of which we included 14 in our review. Our review reveals that there is no universally prescribed approach to fixate knee prostheses. The determination of the most suitable method necessitates an individualized decision-making process involving the active participation and informed consent of each patient.
... Poly(methyl methacrylate) (PMMA) is a biocompatible polymer, well established in medical applications, with mechanical properties similar to bone [23,24]. PMMA was investigated as a polymer with long-term stability after implantation [25]. ...
The study explores the in vitro biocompatibility and osteoconductivity of poly(methyl methacrylate)/nano-hydroxyapatite (PMMA/nHA) composite nanofibrous scaffolds for bone tissue engineering (BTE). Electrospun scaffolds, exhibiting both low and high fiber orientation, were investigated. The inclusion of hydroxyapatite nanoparticles enhances the osteoconductivity of the scaffolds while maintaining the ease of fabrication through electrospinning. SEM analysis confirms the high-quality morphology of the scaffolds, with successful incorporation of nHA evidenced by SEM-EDS and FTIR methods. DSC analysis indicates that nHA addition increases the PMMA glass transition temperature (Tg) and reduces stress relaxation during electrospinning. Furthermore, higher fiber orientation affects PMMA Tg and stress relaxation differently. Biological studies demonstrate the composite material's non-toxicity, excellent osteoblast viability, attachment, spreading, and proliferation. Overall, PMMA/nHA composite scaffolds show promise for BTE applications.
... During vertebroplasty and kyphoplasty procedures, the preparation of cement stands as a crucial step influencing the physical characteristics of the bone cement. Past research has highlighted several contributing factors, including temperature, humidity, solution ratio, blending speed during preparation, and the introduction of blood or normal saline [52,53]. In our established protocol, we ensured precise cement preparation within a controlled-temperature environment in the operating room to mitigate temperature-related effects. ...
Symptomatic osteoporotic compression fractures are commonly addressed through vertebroplasty and kyphoplasty. However, cement leakage poses a significant risk of neurological damage. We introduced “aspiration percutaneous kyphoplasty”, also known as “decompressed kyphoplasty”, as a method to mitigate cement leakage and conducted a comparative analysis with high viscosity cement vertebroplasty. We conducted a retrospective study that included 136 patients with single-level osteoporotic compression fractures. Among them, 70 patients underwent high viscosity cement vertebroplasty, while 66 patients received decompressed percutaneous kyphoplasty with low-viscosity cement. Comparison parameters included cement leakage rates, kyphotic angle alterations, and the occurrence of adjacent segment fractures. The overall cement leakage rate favored the decompressed kyphoplasty group (9.1% vs. 18.6%), although statistical significance was not achieved (p = 0.111). Nonetheless, the risk of intradiscal leakage significantly reduced in the decompressed kyphoplasty cohort (p = 0.011), which was particularly evident in cases lacking the preoperative cleft sign on X-rays. Kyphotic angle changes and the risk of adjacent segment collapse exhibited similar outcomes (p = 0.739 and 0.522, respectively). We concluded that decompressed kyphoplasty demonstrates efficacy in reducing intradiscal cement leakage, particularly benefiting patients without the preoperative cleft sign on X-rays by preventing intradiscal leakage.
... For polymer materials, there are several types of modifications: chemical modifications, physical modifications and physical-chemical modifications. Chemical modifications involve, for example, changing the type and amount of hardener to adjust the curing time, strength, chemical and low/high temperature resistance of the material [18][19][20][21]. In physical modifications of epoxy resins, the most commonly used agents include fillers, stabilizers, plasticizers and thinners. ...
The aim of this research was a comparative analysis of selected mechanical properties of epoxy compounds that were modified with metallic fillers and aged in aqueous environments. The tested epoxy compounds consisted of three components: styrene modified epoxy resin based on Bisphenol A, triethylenetetramine curing agent (resin/curing agent ratio of 100:10) and two types of metallic fillers in the form of particles: aluminum alloy (EN AW-2024–AlCu4Mg1) and tin-phosphor bronze (CuSn10P). Samples were subjected to ageing in 4 water environments: low-, medium- and high-mineralized natural water and in a sugar-containing solution for 1, 2 and 3 months. The epoxy samples were subjected to compressive strength tests in accordance with the ISO 604:2002 standard. It was observed that, among others, the compositions seasoned in low-mineralized water usually achieved the highest average compressive strength. As for filler type, using the bronze filler (CuSn10P) usually achieved the highest average compressive strength results.
... Apart from these, a series of constitutive models have been found to successfully understand and record the compressive response of PMMA bone cement-like polymers [15][16][17]. The bone cement constituent's mixing ratio [18,19], mixing techniques [20], and presence of blood [21,22] and antibiotics [23] in bone cement also influence its mechanical properties. However, the existing various constitutive models for polymer materials cannot fully describe the large compressive deformation characteristic over a range of strain rates of PMMA bone cement. ...
A new mathematical model of compressive stress-strain behaviour of low viscosity (LV) and high viscosity (HV) bone cement has been proposed to capture large uniaxial deformation under constant applied strain rate by incorporating three-term power law. The modeling capacity of the proposed model has been validated using uniaxial compressive test under eight different low strain rates ranging from 1.39 × 10-4 s-1 to 3.53 × 10-2 s-1 for low viscosity and high viscosity bone cement. The well agreement between the model and experimental response suggests that the proposed model can successfully predict rate dependent deformation behavior for Poly(methyl methacrylate) (PMMA) bone cement. Additionally, the proposed model was compared with the generalized Maxwell viscoelastic model and found to be in good agreement. The comparison of compressive responses over low strain rates for LV and HV bone cement reveals their rate-dependent compressive yield stress behaviour along with a higher value of compressive yield stress of LV bone cement compared to HV bone cement. For example, at the strain rate of 1.39 × 10-4 s-1 the mean value of compressive yield stress of LV bone cement was found to be 64.46 MPa, whereas for HV bone cement it was 54.00 MPa. Moreover, the modeling of experimental compressive yield stress with the Ree-Eyring molecular theory suggests that the variation of yield stress of PMMA bone cement can be predicted using two processes Ree-Eyring theory. The proposed constitutive model might be useful to characterize large deformation behaviour with high accuracy for PMMA bone cement. Finally, both variants of PMMA bone cement also exhibit ductile-like compressive behaviour below the strain rate of 2.1 × 10-2 s-1, whereas above this threshold strain rate, brittle-like compressive failure behavior is observed.
... Then, the surgeon sutures the wound together with the graft and the membrane, which protects the newly transplanted tissue against too-fast resorption [86]. The use of bone substitutes is increasingly noticed, and they are used with two main advantages in mind: an ability to integrate with the regenerating bone and a strength similar to the [87,88] cortical bone. The most commonly used are ceramics or hydroxyapatite cement, which the patient's bone uses up and replaces with bone tissue [89][90][91]. ...
The application of 3D printing in bone grafts is gaining in importance and is becoming more and more popular. The choice of the method has a direct impact on the preparation of the patient for surgery, the probability of rejection of the transplant, and many other complications. The aim of the article is to discuss methods of bone grafting and to compare these methods. This review of literature is based on a selective literature search of the PubMed and Web of Science databases from 2001 to 2022 using the search terms "bone graft", "bone transplant", and "3D printing". In addition, we also reviewed non-medical literature related to materials used for 3D printing. There are several methods of bone grafting, such as a demineralized bone matrix, cancellous allograft, nonvascular cortical allograft, osteoarticular allograft, osteochondral allograft, vascularized allograft, and an autogenic transplant using a bone substitute. Currently, autogenous grafting, which involves removing the patient's bone from an area of low aesthetic importance, is referred to as the gold standard. 3D printing enables using a variety of materials. 3D technology is being applied to bone tissue engineering much more often. It allows for the treatment of bone defects thanks to the creation of a porous scaffold with adequate mechanical strength and favorable macro-and microstructures. Bone tissue engineering is an innovative approach that can be used to repair multiple bone defects in the process of transplantation. In this process, biomaterials are a very important factor in supporting regenerative cells and the regeneration of tissue. We have years of research ahead of us; however, it is certain that 3D printing is the future of transplant medicine.
... Critical bone defects, defined as being more than 2 cm in length or surpassing 50 percent of the circumference of the defect, necessitate the addition of biomaterials for their repair, as they are not otherwise capable of full regeneration [2]. Self-polymerizing biomaterials, known as bone cements, are utilized for bone defect treatment in orthopedics, traumatology, or maxillofacial surgery, after trauma or bone tumor resection [3,4]. Recent trends have focused on the research and development of biomaterials for bone repair that have proven to have high scientific and clinical value. ...
Bone regeneration has gained attention in the biomedical field, which has led to the development of materials and synthesis methods meant to improve osseointegration and cellular bone activity. The properties of hydroxyapatite, a type of calcium phosphate, have been researched to determine its advantages for bone tissue engineering, particularly its biocompatibility and ability to interact with bone cells. Recently, the advantages of utilizing nanomolecules of hydroxyapatite, combined with various substances, in order to enhance and combine their characteristics, have been reported in the literature. This review will outline the cellular and molecular roles of hydroxypatite, its interactions with bone cells, and its nano-combinations with various ions and natural products and their effects on bone growth, development, and bone repair.
... Buchholz and Engelbrecht first introduced antibiotics-loaded bone cement, composed of polymethyl methacrylate (PMMA) and its monomer, in the 1970s [5]. Even though the mechanical strength will be affected by an improper mix ratio or environment and additional biodegradable materials, such as different types of antibiotics, antibioticloaded bone cement still remains important in clinical usage [6][7][8][9]. ...
Background:
Antibiotic-loaded bone cement (ALBC) spacers are used in the first stage when treating periprosthetic joint infection (PJI). This study aimed to investigate whether a spacer made from commercial ALBC or plain bone cement with additional antibiotics could affect the spacer exchange rate before reimplantation.
Methods:
Patients undergoing two-stage exchange arthroplasty due to chronic PJI from January 2014 to August 2021 were retrospectively reviewed. The exclusion criteria included arthroplasty in the setting of septic arthritis, megaprosthesis, atypical pathogen infection, spacer placement unrelated to PJI, and spacer exchange due to mechanical complications. The patient demographics, brand of cement, and microbiology were recorded manually. The primary outcome was the incidence of spacer exchange due to persistent infection and the secondary outcome was the incidence of reinfection after reimplantation. A multivariate logistic regression analysis and Chi-square test were conducted to identify the effect of cement type on the spacer exchange.
Results:
A total of 334 patients underwent two-stage exchange arthroplasty for PJI. The spacer exchange rates in the commercial and non-commercial ALBC groups were 6.4% and 25.1%, respectively (p = 0.004). After controlling for confounding factors, there were significant differences between the commercial group and non-commercial groups in the spacer exchange rate (adjusted OR = 0.25; 95% CI = 0.72-0.87, p = 0.029). The use of commercial ALBC was not associated with a lower reinfection rate after reimplantation (p = 0.160).
Conclusions:
In a two-stage exchange arthroplasty scenario, the spacer comprised of commercial ALBC resulted in a lower spacer exchange rate than the plain bone cement, both of which had additional antibiotics. However, the use of commercial ALBC was not associated with a lower incidence of reinfection following reimplantation.
... It is also possible to develop custom compositions by reacting one of the many available epoxy resins with selected hardeners (e.g., amine). When preparing adhesives (as well as other, two-component polymeric materials [39][40][41][42]), the correct stoichiometric ratio of the curing resin and hardener is crucial. This can determine not only the strength of the adhesive bond but many other performance parameters such as the resistance to heat, harmful environmental influences, oils, etc. ...
This paper presents the results of an experimental study of adhesive joint strength with consideration of the inaccuracy of the hardener dosage, in the context of evaluating the degradation of joints when used either at ambient or elevated temperatures. The butt joint strength characteristics were assessed for two types of adhesives-rigid and flexible-and two curing scenarios-with and without heat curing. An excess hardener was shown to be significantly more unfavourable than its deficiency, which can ultimately be considered as a recommendation for forming epoxy adhesive joint assemblies. In order to fully understand the relationship between the analysed mechanical properties of the material and the influence of component ratio excesses and heating, a process of fitting basic mathematical models to the obtained experimental data was also performed.
