Figure 7 - Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage

Cerebellar pathology in aldr 2 / 2 mice at 20 months of age. ( B ) Loss of Purkinje cell somata evidenced by Nissl staining (arrowheads). ( D ) Focal loss of staining with anti-calbindin D28K in the aldr 2 / 2 mice. ( F ) Focal upregulations of GFAP expression in aldr 2 / 2 . ( H ) Strong reduction of non-phosphorylated neurofilaments in Purkinje cells was seen by staining with anti-SMI32. ( A , C , E and G ) Images from wild-type littermate controls. Scale bar: 50 m m.

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Reference

Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/Cerebellar-pathology-in-aldr-2-2-mice-at-20-months-of-age-B-Loss-of-Purkinje-cell_fig7_7542256 [accessed 30 Jun, 2024]

Caption

Figure 7. Cerebellar pathology in aldr 2 / 2 mice at 20 months of age. ( B ) Loss of Purkinje cell somata evidenced by Nissl staining (arrowheads). ( D ) Focal loss of staining with anti-calbindin D28K in the aldr 2 / 2 mice. ( F ) Focal upregulations of GFAP expression in aldr 2 / 2 . ( H ) Strong reduction of non-phosphorylated neurofilaments in Purkinje cells was seen by staining with anti-SMI32. ( A , C , E and G ) Images from wild-type littermate controls. Scale bar: 50 m m.

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<a href="https://www.researchgate.net/figure/Cerebellar-pathology-in-aldr-2-2-mice-at-20-months-of-age-B-Loss-of-Purkinje-cell_fig7_7542256"><img src="https://www.researchgate.net/profile/Aurora-Pujol/publication/7542256/figure/fig7/AS:311381107724294@1451250449513/Cerebellar-pathology-in-aldr-2-2-mice-at-20-months-of-age-B-Loss-of-Purkinje-cell.png" alt="Cerebellar pathology in aldr 2 / 2 mice at 20 months of age. ( B ) Loss of Purkinje cell somata evidenced by Nissl staining (arrowheads). ( D ) Focal loss of staining with anti-calbindin D28K in the aldr 2 / 2 mice. ( F ) Focal upregulations of GFAP expression in aldr 2 / 2 . ( H ) Strong reduction of non-phosphorylated neurofilaments in Purkinje cells was seen by staining with anti-SMI32. ( A , C , E and G ) Images from wild-type littermate controls. Scale bar: 50 m m."/></a>