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Microcapsules (MC) based on chitosan (CH) and including nano-magnetite and erlotinib were synthesized. The microparticles were characterized by SEM, FT-IR and TGA. The percentage of encapsulation was determined, as well as its microbiological activity. Finally, the effectiveness of the formulation was evaluated in terms of cell viability and/or tox...
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... toxicity analyses of synthesized microparticles were performed using the MTT methodology in "eternal" human lung cancer cells of the H1299 line, at the Institute of Pharmacology and Morphophysiology of the Austral University of Chile. Cellular viability (in percentage) versus concentration logarithm is shown in Figure 4. ...
Citations
... In the field of drug delivery, various forms of this versatile polymer have been adopted for this purpose: tablets, beads, films, aerogels [26], hydrogels [27], nanofibers [28], nanoparticles, conjugates, and nanocomposites (including other materials and the drug) [29], Figure 3. The most important properties that chitosan provides when included in drug delivery systems is the protection of the physiological environment [30], increases bioavailability, is biocompatible, so it will not generate toxicity [31]. Its metabolism within the biological system will lead to the decomposition into monomeric units easily absorbable and useful to the organism [32] aided by the action of lysozyme (present in the lung, liver, and bloodstream) which causes hydrolytic degradation of the acetylated residue of Cs [33]. ...
The aim of this review is to provide an overview of the delivery systems of chitosan-based chemotherapy agents that have been developed for the treatment of tumor cancer. Cancer treatment is a challenge that has always provided opportunities in different areas of study, due to its very complexity. Innovative options to make chemotherapy an effective treatment by targeting drugs to cancer cells through different modifications in delivery systems are being investigated. Chitosan, a biopolymer that is obtained from the partial deacetylation of chitin (the second most abundant biopolymer on earth) and is present in the exoskeleton of crustaceans, some insects, and also in the cell wall of some fungi. Chitosan has specific characteristics of solubility, functional groups in its structure, crosslinking power, affinity with other materials, biocompatibility, biodegradability, muco adhesiveness, provides bioavailability of the chemotherapeutic agent on cancer cells, without harming healthy cells. This document compiles some interesting studies on the use of chitosan in conjugation with other agents and safe materials for use in biomedicine, for the design, characterization, and development of new transport systems for chemotherapeutic agents, increasing the efficacy of this therapy in cancer treatment tumors.
