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-Caso 1: Sarcoma de Kaposi -(A) e (B) Fotografias clínicas da doente. (C) Exame histológico de biópsia realizada no dorso do pé, com coloração hematoxilina-eosina. (D) Exame imunohistoquímico com positividade para CD31. (E) Exame imunohistoquímico com marcação nuclear com anti-HHV8.
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O diagnóstico dos sarcomas cutâneos é desafiante, devido à complexidade e heterogeneidade deste gru- po de lesões, cuja apresentação nos tecidos superficiais (pele e tecido celular subcutâneo) impõe diagnóstico diferen- cial obrigatório com tumores benignos e processos inflamatórios. Apesar de serem tumores pouco frequentes alguns tipos assumem gra...
Context in source publication
Context 1
... pelos membros e região cervical com algumas semanas de evolução. O exame histopatológico da biópsia cutânea revelou uma proliferação fusocelular que desenhava espaços vasculares angulosos em fenda; a positividade para o CD31 que confirmou a diferenciação vascular e a marcação nuclear com anti-HHV8 corroboraram o diagnóstico de sarcoma de Kaposi. (Fig. 1) O estudo complementar excluiu envolvimento de órgão. Foi proposta revisão e alteração da terapêutica imunossupressora, tendo sido efectuado switch de ciclosporina para sirolimus, com melhoria clínica e regressão das lesões ao fim de um ...
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Citations
... • Idiopathic angiosarcoma: the most common type, especially in the elderly, characterized by ecchymotic plaques and/or friable violaceous nodules, ulcerated or not, usually on the head and neck; • Angiosarcoma secondary to chronic lymphedema: a violaceous nodule or infiltrated plaque more common in mastectomized patients who underwent axillary clearance (Stewart-Treves syndrome); • Post-radiation angiosarcoma: a rare sarcoma associated with conservative treatment of breast cancer usually presenting as infiltrated plaques or nodules adjacent to the irradiated area; and • Low-grade angiosarcomas 1 .Cutaneous angiosarcoma is a rare tissue soft tissue sarcoma with an incidence of approximately 2% and a poor prognosis 2 . This disease is most common in the age group >60 years and in men (2:1 ratio) 3 . ...
Cutaneous angiosarcoma is a rare soft tissue sarcoma with a poor prognosis and an incidence of approximately 2.0%. This entity manifests as bruises, violaceous nodules and plaques, and diffuse hemorrhagic lesions with infiltrative growth. Here we report a case of an 80-year-old Caucasian man who presented with a nodular, hard, and dark lesion present in the upper third of the right ear for more than 1 year. The treatment of cutaneous angiosarcoma is multidisciplinary, including surgery alone or combined with radiotherapy for early lesions and chemotherapy for disseminated lesions. Cutaneous sarcomas are rare, and their appropriate treatment and follow-up are critical.
Keywords:
Hemangiosarcoma; Sarcoma; Skin neoplasms; Skin; Prognosis
... 4,5 Halving immunosuppression is the first-line treatment in immunosuppressed patients, and in most cases total regression of KS lesions is observed, nevertheless, it is challenging to maintain the balance between risks and benefits both for the graft and KS. 5,7,9 Prognosis in patients with KS limited to the skin is favorable, whereas visceral involvement is associated with high mortality. 10 Visceral disease is observed in up to 25% of kidney transplant recipients with KS. 4 For these patients and those with extensive and progressive mucocutaneous disease like our patient, systemic chemotherapy is the therapy of election. ...
Kaposi sarcoma is a low-grade vascular tumor, associated with human herpesvirus-8 infection. Solid organ transplant recipients have a much higher risk of this malignancy, with estimated incidence rates increased 84 to 500 times. The risk is even higher in some ethnic groups, already with a higher incidence of this disease.
We report a case of a 37-year-old African male, a kidney transplant recipient, with a Kaposi sarcoma refractory to different treatment options. The present case puts in evidence the challenges associated with the management of this disease in this high-risk population and highlights the role of a multidisciplinary approach to achieve effective treatment, particularly in advanced and refractory forms.
Acute gastroenteritis caused by rotavirus represents a clinical episode of high relevance to brazilian public health due to its significant mortality rate in children under five years old, even with the existence of vaccination program. In Brazil, Rotarix® from GlaxoSmithKline, a live attenuated vaccine has been used in children since 2006. The present study evaluated the effectiveness of vaccination in the semiarid region of the Brazilian State of Paraiba by reporting cases of diarrhea, clinical data from the disease in 2005 to 2013 and the detection of viral antigens in the stools of hospitalized children in the years 2012 and 2013. The data showed that, as of 2006, the year of vaccine implantation in the brazilian immunization calendar, there was no significant reduction in the number of cases of diarrhea, with an increase in cases of diarrhea approximately four times in the year 2013, compared to previous years. The RIDA®QUICK Rotavirus/Adenovirus rapid test detected the presence of viral antigens in the stools of hospitalized children, indicating the circulation of viral particles in the environment. One should also consider the impact of other causes associated with these unexpected outbreaks of diarrhea in the region.
