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![Case 2. (a) On histology (H&E, original magnification ×10), verrucous nevoid melanoma displays epidermal hyperplasia, elongation of rete ridges, and overlying hyperkeratosis resembling dermal nevus. (b) However, higher magnifications (×20) reveal a hypercellular lesion with intraepidermal and dermal proliferation of atypical nonmaturing melanocytes. [Copyright: ©2018 Apalla et al.]](profile/Mattheos-Bobos/publication/329247515/figure/fig1/AS:697978150977537@1543422367395/Case-2-a-On-histology-H-E-original-magnification-10-verrucous-nevoid-melanoma.png)
Case 2. (a) On histology (H&E, original magnification ×10), verrucous nevoid melanoma displays epidermal hyperplasia, elongation of rete ridges, and overlying hyperkeratosis resembling dermal nevus. (b) However, higher magnifications (×20) reveal a hypercellular lesion with intraepidermal and dermal proliferation of atypical nonmaturing melanocytes. [Copyright: ©2018 Apalla et al.]
Source publication
Background:
In spite of recent advances in the histopathological and molecular diagnosis of melanocytic neoplasms, a certain proportion of these lesions remain a daunting challenge for both the clinician and the pathologist.
Objectives:
To emphasize the importance of close collaboration between clinicians and pathologists in case of problematic...
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Human skin is the most exposed part of the human body that needs constant protection and care from heat, light, dust, and direct exposure to other harmful radiation, such as UV rays. Skin cancer is one of the dangerous diseases found in humans. Melanoma is a form of skin cancer that begins in the cells (melanocytes) that control the pigment in huma...
Citations
... An atypical network frequently (88%) causes the presence of eccentric hyperpigmentation on dermoscopy [61,62]. The lentiginous melanocytic proliferation along with the DEJ characteristic of the lentiginous melanoma on sun-damaged skin of the elderly also correlates with an atypical network on dermoscopy [63,64]. Non-carriers of MC1R (Melanocortin-1 Receptor) R variants develop SSM dermoscopically characterized by an atypical pigment network which is more frequent in darky-pigmented patients and less frequent in individuals with red hair colour [37]. ...
Dermoscopy is a non-invasive, in vivo technique that allows the visualization of subsurface skin structures in the epidermis, at the dermoepidermal junction, and in the upper dermis. Dermoscopy brought a new dimension in evaluating melanocytic skin neoplasms (MSN) also representing a link between clinical and pathologic examination of any MSN. However, histopathology remains the gold standard in diagnosing MSN. Dermoscopic–pathologic correlation enhances the level of quality of MSN diagnosis and increases the level of confidence of pathologists. Melanoma is one of the most genetically predisposed among all cancers in humans. The genetic landscape of melanoma has been described in the last years but is still a field in continuous evolution. Melanoma genetic markers play a role not only in melanoma susceptibility, initiation, and progression but also in prognosis and therapeutic decisions. Several studies described the dermoscopic specific criteria and predictors for melanoma and their histopathologic correlates, but only a few studies investigated the correlation among dermoscopy, pathology, and genetic of MSN. The aim of this work is to review the published data about dermoscopic features of melanoma, their histopathological correlates with regards also to genetic alterations. Particularly, this review will focus on low-CSD (cumulative sun damage) melanoma or superficial spreading melanoma, high-CSD melanoma, and nevus-associated melanoma.
Objective BRCA1-Associated-Protein (BAP1) tumor predisposition syndrome (BAP1-TPDS) is associated with an increased risk for aggressive cancers. BAP1-inactivated melanocytic tumors (BIMTs) are observed in 75% of BAP1-TPDS, often presenting as early as the second decade of life. These lesions may serve as a predictive marker to identify patients who carry germline BAP1 mutations and thus are at higher risk of developing associated cancers. Early diagnosis for these malignancies is crucial for curative treatment.
Methods We report a patient who presented with an incidental scalp papule for which biopsy was consistent with a BIMT. A review of literature was conducted by accessing the PubMed database to delineate present knowledge of BIMTs, assess recommendations for screening of germline BAP1 mutations, and evaluate cancer surveillance strategies for BAP1-TPDS associated cancers.
Results Consensus in literature indicates that genetic evaluation should be encouraged in patients presenting with multiple BIMTs or a new BIMT with significant family history of BAP1-TPDS related cancers. If positive for a germline BAP1 mutation, cancer surveillance should be recommended for early diagnosis and timely intervention.
Conclusion Further workup should be encouraged in patients who meet the proposed screening criteria for germline BAP1 mutations. Patients could benefit from cancer surveillance for earlier diagnosis, management, and improved outcomes.
