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Colon targeted tablets were prepared in two steps. Initially core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethyl cellulose, Eudragit L100 and S100 were used as coating polymers. FT-IR studies were carried out to find out the possible interaction between the selected drugs and polymer. FT-IR st...
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In the present research work colon formulation of Pinaverium targeted to colon by using various polymers developed. To achieve pH-independent drug release of Pinaverium, pH modifying agents (buffering agents) were used. Colon targeted tablets were preparedin two steps. Initially core tablets were prepared and then the tablets were coated by using d...
Citations
... Table 2, clearly shows the classification of powder flow based on AOR values. The following 5 groups as seen in Table can be used to classify powders, in general, a smaller AOR denotes better flow characteristics [19]. ...
... Used un-sieved powder of manufacturer 2 Table 2 The AOR classification of flow characteristics. [19]. was sieve size. ...
... P2 (virgin powder of manufacturer 2) has the highest angle of repose of 32°amongst the other powders. It still falls within the category of unconstrained flow, though the lower the repose angle the better the flowability of the powder [19]. ...
... The flow properties to obtain an easy-to-produce product were determined according to the standard procedure. All tablet formulations were found to have good to excellent flow characteristics as the values of the angle of repose ranged from 26.4 ± 0.18 to 30.0 ± 0.06 • , the compressibility index from 11.28 ± 0.02 to 13.16 ± 0.01%, and the Hausner ratio from 1.12 ± 0.02 to 1.14 ± 0.18 [22,[26][27][28][29]. ...
... Clarithromycin (Active Pharmaceutical Ingredient) ( Figure 1A) showed a specified spectrum similar to that of its formulation (F1) ( Figure 1B), thus indicating the lack of any interaction. ratio from 1.12 ± 0.02 to 1.14 ± 0.18 [22,[26][27][28][29]. ...
Controlled-release effervescent floating bilayer tablets reduce dosage frequency and improve patient compliance with enhanced therapeutic outcomes. Generally, two different tablets of clarithromycin and esomeprazole, respectively, are given for the treatment of Helicobacter pylori infection and it might be worth incorporating both in a single tablet. In the current study, controlled-release floating bilayer tablets of clarithromycin and esomeprazole (F1–F4) were developed with different rates of polymeric materials by a direct compression method. During the formulation, Fourier-transform infrared spectroscopy (FTIR) analysis was performed for possible interactionsmbetween drugs and excipients. No interactions between drugs and excipients were noted. Moreover, the bilayer tablets’ thickness, diameter, friability, hardness, weight variation, dissolution, and percent
purity were found within the acceptable limits. The floating lag time and total floating time of all formulations were found to be < 25 s and 24 h, respectively. The release of both the clarithromycin and esomeprazole started at the same time from the controlled-release floating bilayer tablets by anomalous non-Fickian diffusion, and the polymeric materials extended the drug release rate up to 24 h. In the case of F1, the results approached ideal zero-order kinetics. The dissolution profiles of the tested and reference tablet formulations were compared, but no significant differences were observed. It can be concluded that such controlled-release effervescent floating bilayer tablets can be efficiently used in clinical practice to reduce dosage frequency and increase patient compliance with continuous
drug release for 24 h, which ultimately might enhance therapeutic efficacy.
... Suf icient concentration of the drug has to reach the target site to exert the desired therapeutic bene it. This is achieved by using a drug delivery system of suitable characteristics by employing polymeric structures (Santoshnaidu et al., 2014;Durga et al., 2020). Table 1 clearly shows the bodyweight of each rat before and after treatment with Vigna mungo polymer. ...
The aim of the present research is to investigate acute toxicity profiling of isolated Vigna mungo new natural polymer. Safety administration is the primitive criterion for any drug substance. To explore the safety and toxicity profiling of the novel polymer, this study was carried out. Vigna mungo novel polymer was isolated from the pulverised seeds of Vigna mungo which is part and parcel of our diet. This polymer is obtained using a non-solvent extraction method using acetone. Acute toxicity studies were performed according to the OECD guidelines 420. In this, the selected animal model is Swiss albino rats, grouped into control and test containing each three animals. 2000 mg/kg of Vigna mungo polymer was administered to a test group and did not produced any abnormalities and behavioural changes. Furthermore, histopathological studies, body weight, haematological parameters did not presented abnormal values. The observations found 2000mg/kg of a dose of the polymer did not cause lethality and death of any animal till 14 days of a period. It was concluded that Vigna mungo novel polymer is safe to administer up to 2000mg/kg dose. Hence, the novel Vigna mungo polymer is safer for therapeutic use in pharmaceutical formulations.
