Figure - available from: Case Reports in Obstetrics and Gynecology
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Canalicular cholestasis. Note the green-orange pigment located inside the canaliculus. On the right, ballooned hepatocytes (400x, H&E staining). Source: own.
Source publication
Acute fatty liver of pregnancy is a rare but highly fatal disease affecting women most frequently during the third trimester of pregnancy or in the postpartum period. It is considered a diagnosis of exclusion and requires a timely diagnosis to avoid maternal mortality. We present the case of a 33-year-old primigravida who required an emergency cesa...
Citations
... Most cases of AFLP are diagnosed in the third trimester or immediately after birth 13,14 . Isolated cases occurring in the second trimester have been reported 15 . ...
... A definitive and unequivocal confirmation of this pathology is achieved by histologic examination. However, a liver biopsy is not always performed due to the hemorrhagic complications typical of this disease 15 . In AFLP, the pathognomonic sign of the liver biopsy is microvesicular fatty infiltration in the hepatocytes, a specific alteration in this disease. ...
BACKGROUND: Acute fatty liver disease in pregnancy (AFLP) is a low-incidence condition that usually affects women in the third trimester of pregnancy or the early postpartum period. This article reviews recent advances in the diagnosis and treatment of AFLP with pan-creatitis in pregnancy induced by in vitro fertilization (IVF). CASE REPORT: A rare case of AFLP and pan-creatitis occurred in a pregnant woman with an IVF-induced twin pregnancy delivered by cesar-ean section. Diagnosis of this condition is difficult , and delay in accurate diagnosis and timely and appropriate treatment can lead to serious complications such as acute pancreatitis or extensive damage to multiple organs and systems, which can have significant consequences. The main therapeutic approach was the rapid administration of drugs accompanied by therapeutic measures to support liver function and pancre-atic complications. CONCLUSIONS: We would like to reempha-size the importance of multidisciplinary management and rapid intervention in AFLP with acute pancreatitis after IVF.
Acute fatty liver of pregnancy is a rare and critical disease in obstetrics, mainly characterized by liver failure, severe coagulopathy and other clinical manifestations, with rapid progression and high mortality. This article discusses the epidemic characteristics, pathogenesis, clinical manifestations, laboratory examination, clinical diagnosis and treatment of acute fatty liver during pregnancy. This paper summarizes the related contents of perioperative anesthesia in anesthesia methods, drug selection, coagulation regulation, organ protection and postpartum disease outcome.
