Figure 2-
CT scan showing large exophytic hepatocellular carcinoma in cirrhotic liver. (a)-Large HCC right hemi-liver, (b)-Large exophytic HCC in left lateral section. a b
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Hepatocellular carcinoma is the fifth most common cancer worldwide and one of the leading causes of cancer-related mortality. The majority of patients with hepatocellular carcinoma have underlying liver cirrhosis as a result of hepatitis B or hepatitis C virus, and alcoholic hepatitis. Its management in the presence of liver cirrhosis is a complex...
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Context 1
... showed the same worse prognosis (46). Chemoembolization was one of the methods that was tried for such category of tumors with shown poor short-term outcomes and unknown long-term results (47). Among all these options, resection appeared to the best option in large tumors, with proven safety in high volume centers and acceptable morbidity (48-51) (Fig. 2, 3). Shah and his team performed a study to evaluate results of resection in large tumors and comparing them to cases posing smaller tumors (<10cm) and to detect the factors affecting the proposed incidence of recurrence (41). Their results showed that overall survival was not significantly different (54% vs. 53% at 5 years). In ...
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Objective:
This study aimed to evaluate the efficacy, feasibility, and tolerability of ultrasound (US)-guided percutaneous microwave ablation (MWA) for treating hepatocellular carcinoma (HCC) originating in the caudate lobe.
Materials and methods:
The treatment and survival parameters of 32 patients with HCC in the caudate lobe, who met the inclusion criteria and had received US-guided percutaneous MWA in our department from November 2010 to October 2015, were retrospectively analyzed. Imaging examination (contrast-enhanced computed tomography or magnetic resonance) 1 month after MWA was used to evaluate the efficacy of US-guided MWA.
Results:
Thirty-two patients underwent percutaneous MWA for caudate lobe HCC. The average tumor size was 3.42 ± 0.27 (range: 1-6.8) cm. The initial complete ablation (CA) rate was 87.5% (28/32), and the total CA rate was 96.88% (31/32). Furthermore, the median length of hospitalization was 4 days (range: 2-10 days), and no major complication was observed in this study. The overall survival rates were 87.5%, 50%, and 28.13% at 1, 2, and 3 years, respectively. The progression-free survival after MWA was 93.75%, 53.15%, and 28.13% at 6, 12, and 18 months, respectively.
Conclusions:
US-guided percutaneous MWA was a safe and effective treatment. It is a promising alternative therapy for HCC originating in the caudate lobe.
