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Introduction
Kidneys are one of the most commonly affected retroperitoneal organ in trauma cases despite its relatively well-protected location. Renal trauma occurs in 80–95% of urogenital trauma cases and 8–10% of abdominal blunt trauma. Renal trauma in hydronephrotic kidney due to ureteropelvic junction obstruction (UPJO) is a rare entity, despit...
Citations
... Despite their relatively safe retroperitoneal positioning, the kidneys are the most probable genitourinary organ to be damaged by trauma (1)(2)(3). The vasa recta descend into the medullary sections of the kidney and is part of a highly vascularized network that connects cortical glomerular structures (4)(5)(6)(7)(8). ...
Background
Traumatic injuries to renal blood vessels (IRBV) can have significant consequences for patients, impacting their mortality, morbidity, and quality of life.
Objective
This study aimed to compare trauma types and injury characteristics, vital signs, and outcomes in patients with and without IRBV (nIRBV) and examine whether IRBV and pre-existing renal dysfunction affected the likelihood of in-hospital renal complications (iHRC).
Materials and Methods
After identifying penetrating and blunt trauma victims with IRBV in the National Trauma Data Bank, patient demographics, injury-related variables, treatment outcomes, and deaths under care were analyzed and compared.
Results
Of the 994,184 trauma victims, 610 (0.6%) experienced IRBV. Victims in the IRBV group (IRBVG) had a significantly higher frequency of penetrating injuries (19.5% vs. 9.2%, P < 0.001) and higher injury severity score (ISS ≥25, 61.5% vs. 6.7%). Most injuries in both groups were unintentional, although a higher frequency of assault was noted in the IRBVG. The incidence of iHRC was higher in the IRBVG (6.6%) than in the nIRBVG (0.4%; P < 0.001). The IRBV {OR = 3.5 [95% CI = (2.4–5.0)]}, preexisting renal disorders {OR = 2.5 [95% CI = (2.1–2.9)]}, and in-hospital cardiac arrest {OR = 8.6 [95% CI = (7.7–9.5)]} were found to be among the factors associated with a higher risk of iHRC.
Conclusions
IRBV and pre-existing renal disorders considerably increased the risk of developing iHRC. Due to the long- and short-term consequences of associated cardiovascular, renal, and hemodynamic complications, victims of IRBV require specialized renal management and close monitoring.
... Blunt trauma provide an account of the majority of chest traumas, which may cause a great number of complications (2).Most abdominal traumas are closed injuries, which account for 80-90% of cases (3). There is a high rate of blunt trauma to the kidneys, which is usually caused by motor vehicle accidents (63%) (4).In blunt abdominal trauma, the spleen is the most commonly injured organ,which is approximately 46% (5). ...
Background
Whether blunt trauma patient will get venous thromboembolism (VTE) is still a huge challenge to forecast. The objective of our study is to investigate and identify the potential biomarker genes for blunt trauma patients with VTE based on the method of bioinformatics analysis.
Methods
To investigate differentially expressed genes (DEGs) of blunt trauma and VTE, firstly we used the data obtained from the gene expression omnibus (GEO) database, and DEGs were respectively obtained via LIMMA. Next Weighted gene co-expression network analysis (WGCNA) was used to investigate the co-expression network of blunt trauma DEGs and two modules were found. We chose the most significant module as the key one in correlation with blunt trauma. We got intersection of DEGs in blunt trauma and VTE, which were analyzed using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Then we used STRING to create a protein-protein interaction (PPI) network, and hub genes were screened by Cytoscape software and analyzed of functional enrichment. We chose another GEO database to evaluate the value of hub genes, and receiver operating characteristic (ROC) curves were done at last.
Results
There are a total of 546 DEGs of VTE and 4266 DEGs of blunt trauma were screened out from GSE19151 and GSE36809 respectively. Then 1568 DEGs of blunt trauma were identified in the most significant module. And 101 intersections of DEGs were found to be enriched for various functions and pathways. Among these DEGs, 6 overlapped hub genes with high degrees of stress method were selected. These hub genes include MRPL3, RPLP0, MRPL15, TP53, MYC, CD3D.And the six hub genes were tested to have high diagnostic values.
