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CT revealed 9 × 7 mm bladder tumor at the left top of the bladder and showing thickening of the whole bladder wall (a) and bilateral hydronephrosis (b). MRI showed the bladder trigone at coronal
Source publication
Bladder metastasis from lung adenocarcinoma is extremely rare. Unlike primary bladder urothelial tumors, the initial symptoms of this disease vary, and include pelvic pain, dysuria, and hematuria. There are few reports on cases without microscopic hematuria. An 86-year-old woman with a previous history of radiation therapy for lung adenocarcinoma c...
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Context 1
... of 20 ml. Due to the severe and worsening symptoms, imaging studies were performed to detect organic disease. Cystoscopy showed a nodular tumor covered with calcification at the left top wall and mucosal folding change that involved the whole posterior wall. CT revealed a tumor (9 mm × 7 mm) at the dome of bladder, thickening of the bladder wall (Fig. 1a), and right hydronephrosis. Tumor marker levels were within the normal range (carcinoembryonic antigen 3.1 ng/ml, CA19-9 3U/ml, CA125 13U/ml, SCC 1.5 ng/ml, NSE 12.5 ng/ml), which was the same as that at diagnosis of lung carcinoma. 10 days later the patient was debilitated by bilateral back pain, fatigue, and anorexia. CT revealed ...
Context 2
... hydronephrosis. Tumor marker levels were within the normal range (carcinoembryonic antigen 3.1 ng/ml, CA19-9 3U/ml, CA125 13U/ml, SCC 1.5 ng/ml, NSE 12.5 ng/ml), which was the same as that at diagnosis of lung carcinoma. 10 days later the patient was debilitated by bilateral back pain, fatigue, and anorexia. CT revealed bilateral hydronephrosis ( Fig. 1b). RP showed extensive bilateral strictures at the lower part of the ureters. MRI showed distinct boundary between bladder and uterus ( Fig. 2a, b), and Papanicolaou stain of uterine cervix cytology was also negative, then presence of locally invasive cervical cancer was denied. CT and MRI revealed no space occupying lesion except for ...
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Citations
... GATA3 is also a marker of urothelial differentiation, with a sensitivity of up to 67-90% and low specificity because it is widely expressed in ductal and lobar breast cancer. Therefore, to exclude urothelial origin, IHC is recommended (17). Other IHC markers, such as Syn and CgA, are neuroendocrine markers, and PAX8 is used to label metastatic lesions of female reproductive tract origin. ...
Background
Lung cancer is the most common cause of cancer-related mortality in the world. Unfortunately, more than 50% of patients have already metastasized at the time of diagnosis, contributing to morbidity and mortality. Common sites of metastasis are adrenal glands, liver, bone, and brain. Bladder metastasis is rare and should prompt a careful differential consideration of primary bladder cancer.
Case description
Here, we report a 72-year-old female who went to the hospital for “gross hematuria for one day”. Cystoscopy showed space-occupying lesions in the bladder. During the general CT examination, space-occupying lesions in the lower lobe of the lung were found. Peripheral lung cancer with multiple lymph node metastases, pulmonary metastasis, and left pleural effusion were considered. Transurethral cystoscopic resection of the bladder tumor and pleural effusion cell block examination were performed to clarify the diagnosis. Combined with morphological and immunohistochemical results, both pathological results supported a diagnosis of lung adenocarcinoma metastasis, and gene detection was carried out. EGFR, ALK, and ROS-1 were negative. According to the genetic testing results, there was no corresponding targeted drug, so we administered chemotherapy, and one-year survival was achieved, which was better than expected based on other studies.
Conclusion
This paper describes a case of lung adenocarcinoma metastatic to the bladder and includes a review of the literature to provide clinicians with diagnostic and treatment experience and help avoid misdiagnosis and mistreatment.
