Figure 2
Source publication
Virilising ovarian tumours account for less than 5% of all ovarian tumours. A steroid cell tumour (SCTs) of the ovary comes under the sex cord stromal tumours and accounts for only 0.1% of all ovarian tumours. Almost 75% are functioning tumors with production of androgenic hormones causing virilisation and cushingoid features. They are usually unil...
Context in source publication
Context 1
... was performed under general anesthesia and was proceeded to right salphingo-oophorectomy. Right ovary showed a well encapsulated cystic mass measuring 3.5x4 cm. The specimen was sent for frozen section which showed features suggestive of steroid cell tumour of ovary. In view of fertility issues, the procedure was ended with right salphigo-oophorectomy. Macroscopically, the right ovary measured 4.5x3.5x2 cm with attached tube measured 4.5 cm in length. External surface was homogenous white, soft in consistency with smooth surface. Cut surface of ovary showed a well circumscribed, solid orange yellow mass measuring 1.5 cm in diameter ( Figure 2). 5ml of peritoneal aspirate fluid was sent for cytological analysis. ...
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Introduction
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Citations
... NOS tumors are the most common subtype and comprise the largest proportion of cases (60%), whereas stromal luteoma and Leydig-cell tumors each account for $20% of cases. [1][2][3] A SCT of the ovary was first described in 1943 as a "virilizing lipoid cell tumor" by Gemma Barzilai in the Atlas of Ovarian Pathology. 4 Later, the term "lipoid cell tumor" was replaced by "steroid-cell tumor." ...
Ovarian steroid-cell tumors (SCTs) are a rare subgroup of sex-cord tumors of the ovary, accounting for less than 0.1% of all ovarian tumors. Not otherwise specified (NOS) tumors are the most common subtype. More than half of patients with SCTs-NOS show hyperandro-genic symptoms. The primary treatment for SCTs is surgery, as most cases are early-staged and benign. Because of the low incidence of metastatic disease, there is insufficient reliable information on the role of adjuvant therapy and the most effective treatment regimen. In this report, a rare case of a recurrent SCT-NOS in a 36-year-old female patient without endocrine symptoms is presented, highlighting the significance of appropriate pathological evaluation and immunohisto-chemical testing for the accurate diagnosis of this malignancy, particularly in the case of hormonally "silent" tumors. The metastatic tumor described here showed no response to four courses of adjuvant chemotherapy after several debulking surgeries. Based on the clinical findings, the neoplastic etiology should always be considered during the resection of ovarian tumors to prevent possible disease dissemination due to inappropriate surgical techniques.
... Steroid cell tumour was first described by Scully to contribute for less than 0.1% of all ovarian neoplasm [1,5]. 60 % of SCT are NOS category [6] and more than 90% of the NOS are unilateral [1,7,8]. ...
Steroid cell tumour is a rare sex cord-stromal tumor of the ovary. It may produce steroids and is associated with testosterone secretion which causes symptoms like hair loss, hirsutism, and oligomenorrhea/amenorrhea due to hormonal activity and virilizing properties of tumor. In this article, we reported a 27-year-old woman who presented with hirsutism, hoarseness of voice, scalp hair fall, and amenorrhea for 8 years. Clinical and diagnostic evaluation revealed a left adnexal mass and elevated serum levels of testosterone and she was diagnosed as having a Sertoli Leydig cell tumour of ovary. She underwent left salpingooophorectomy and both histopathological examination and immunohistochemistry confirmed the diagnosis. Her serum testosterone levels normalized 3 days after the surgery and her menses resumed spontaneously a few months after the operation. In addition, we reviewed the literature on the epidemiology, clinical presentations, imaging and histological findings, and the treatment options on this disease.
