Brain cortex of group 1 piglets. At high power, neurons undergoing apoptosis show relevant nuclear changes with chromatin condensation and nuclear pyknosis (800x). 

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... hypoxic piglets exhibited significantly dif- ferent histological picture of their brain cortices compared to that of control animals. In the vast majority of cases, the principal pathological change was apoptosis of neurons. Neurons undergoing apoptotic cell death were characterized by condensation of the cytoplasm, which resulted in a hypereosinophilic cell. Hypereosinophilia was followed by cell shrinkage and chromatin condensation, resulting in hyperchromatic nuclei (Figure 2). Apoptotic neurons were, in the majority of cases, scattered, intermingled among adjacent normal neurons (Figure 3). In some cases, apoptosis appeared more diffuse, interestingly in a large number of cortical neurons ( Figure 4). Apoptotic cells were observed both in the superficial and in the deep cortical layers. Cerebral oedema was present in a minority of cases. No significant vascular changes were ...