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Brain autopsy gross section. Multiple tan-yellow circumscribed abscesses, ranging from 4 to 10 mm in size, were identified in the brain, including one in the left internal capsule (arrow). Similar lesions were present in the right caudate nucleus, right thalamus, and the left inferior frontal lobe white matter.
Source publication
Mycobacterium haemophilum is a slow growing nontuberculous mycobacterium which prefers cooler temperatures and requires iron for growth. It usually causes skin and soft tissue infections in immunocompromised hosts and cervical lymphadenitis in healthy children. We present the case of fatal disseminated M. haemophilum in an immunocompromised host wi...
Citations
... Intracranial infection caused by NTM is a very uncommon occurence. The cases reported in the literature are mainly related to the retention of intracranial hardware in neurosurgery or individuals with immunosuppressed conditions such as human immunodeficiency virus (HIV) infection (6)(7)(8)(9)(10)(11)(12)(13)(14). Furthermore, there are some cases related to trauma, especially traumatic head injury including facial fracture and facial gunshot injury (5,15,16). ...
Nontuberculous mycobacteria (NTM) are exceedingly rare etiological agents of intracranial infections. Among them, Mycobacterium rhodesiae stands out as an even less common pathogen. In this paper, we report the first documented case of a central nervous system (CNS) infection in humans caused by Mycobacterium rhodesiae, which has specific imaging findings and good response to the therapy by using Linezolid, Clarithromycin, and Minocycline. The diagnosis was facilitated by a comprehensive multimodal approach, incorporating multisite imaging, cerebrospinal fluid analysis via next-generation sequencing (NGS), and targeted genetic testing. Furthermore, this paper provides a derivation of the clinical characteristics observed in other documented instances of CNS infections attributable to NTM and based on a review of the current literature. Our experience contributes to the evidence that is needed to understand the full spectrum of NTM-related CNS pathologies and underscores the importance of a multidisciplinary diagnostic process in atypical presentations of intracranial infections.
... More and more research has confirmed that septic shock is a risk factor for the death of AIDS patients. [25][26][27][28] Among HIV patients infected with Talaromyces marneffei in Beijing Ditan Hospital, septic shock accounted for 10.2% of the total death causes, ranking fourth. 29 A prediction result of hospitalization mortality of HIV/AIDS patients with Talaromyces marneffei infection in Guangxi showed that septic shock was the most important predictor of patient death. ...
Purpose
To analyze the clinical characteristics of AIDS with dTSM, especially in patients with poor prognosis.
Patients and Methods
One hundred and seventy AIDS patients were enrolled in this single-center retrospective study. The epidemiological characteristics, clinical manifestations, laboratory tests, imaging examination, and treatment outcome were collected. Logistic regression analysis was used to estimate the risk of mortality in AIDS patients with dTSM. The predictive value was evaluated using the receiver operating characteristic (ROC) curve.
Results
From 2015 to 2022, the incidence of AIDS with dTSM in the Wenzhou region increased yearly, mainly in young adults. The mortality rate was 16.47%. The most common clinical manifestations were lymph-node enlargement (92.35%) and fever (78.24%). Multivariate logistic regression analysis showed that procalcitonin (PCT), blood urea nitrogen (BUN), shock, and antiretroviral therapy (ART) were the risk factors for poor outcomes. The model comprised four risk factors and showed an excellent prediction performance, with an AUC of 0.987 in the training cohort (95% CI: 0.946–0.999) and 0.976 in the validation cohort (95% CI: 0.887–0.999).
Conclusion
This study suggested that PCT, BUN, shock, and ART were associated with the prognosis and outcome of AIDS with dTSM and had a specific predictive value.
... However, a wide array of clinical manifestations due to M. haemophlium has been reported within the renal transplant population. Cutaneous infection remains the most common presentation though there are rare instances reported of pyomyositis [8], dissemination with brain abscess formation [9], and dissemination with graft involvement [10]. Differences in immunosuppressive intensity likely account for the disease heterogeneity in this population. ...
Mycobacterium haemophilum is an increasingly recognized pathogen of the non-tuberculous mycobacteria family that largely infects immunocompromised adults and immunocompetent children. M. haemophilum is a fastidious and slow-growing organism that exhibits preferential growth at lower temperature with iron supplemented media, and therefore most clinical manifestations involve cutaneous infection or musculoskeletal infection of the distal extremities. It is believed that opportunistic infection occurs in immunocompromised hosts when the organism is acquired through environmental exposure. We describe the case of a 71-year-old renal transplant recipient who developed acute M. haemophilum osteomyelitis of the left foot, likely contracted from Epsom salt soaks with contaminated tap water. Outcomes of M. haemophilum infection are generally favorable in the literature. Our patient was treated with local debridement and partial amputation followed by a 3-drug anti-mycobacterial regimen until definitive amputation could be completed.
Introduction
Nontuberculous mycobacteria (NTM) mediated infections are important to consider in cases with neuroinflammatory presentations. We aimed to characterize cases of NTM with neurological manifestations at the National Institutes of Health (NIH) Clinical Center and review the relevant literature.
Materials and methods
Between January 1995 and December 2020, six cases were identified. Records were reviewed for demographic, clinical, and radiological characteristics. A MEDLINE search found previously reported cases. Data were extracted, followed by statistical analysis to compare two groups [cases with slow-growing mycobacteria (SGM) vs. those with rapidly growing mycobacteria (RGM)] and evaluate for predictors of survival. NIH cases were evaluated for clinical and radiological characteristics. Cases from the literature were reviewed to determine the differences between SGM and RGM cases and to identify predictors of survival.
Results
Six cases from NIH were identified (age 41 ± 13, 83% male). Five cases were caused by SGM [Mycobacterium avium complex (MAC) n = 4; Mycobacterium haemophilum n = 1] and one due to RGM (Mycobacterium abscessus). Underlying immune disorders were identified only in the SGM cases [genetic (n = 2), HIV (n = 1), sarcoidosis (n = 1), and anti-interferon-gamma antibodies (n = 1)]. All cases were diagnosed using tissue analysis. A literature review found 81 reports on 125 cases (SGM n = 85, RGM n = 38, non-identified n = 2). No immune disorder was reported in 26 cases (21%). Within SGM cases, the most common underlying disease was HIV infection (n = 55, 65%), and seizures and focal lesions were more common. In RGM cases, the most common underlying condition was neurosurgical intervention or implants (55%), and headaches and meningeal signs were common. Tissue-based diagnosis was used more for SGM than RGM (39% vs. 13%, p = 0.04). Survival rates were similar in both groups (48% SGM and 55% in RGM). Factors associated with better survival were a solitary CNS lesion (OR 5.9, p = 0.01) and a diagnosis made by CSF sampling only (OR 9.9, p = 0.04).
Discussion
NTM infections cause diverse neurological manifestations, with some distinctions between SGM and RGM infections. Tissue sampling may be necessary to establish the diagnosis, and an effort should be made to identify an underlying immune disorder.
Purpose of Review
Suppurative tenosynovitis is a serious infection mostly affecting the flexor tendons of the hand and is considered a medico-surgical emergency.
Recent Findings
Infectious tenosynovitis is mostly caused by Staphylococci, Streptococci, Gram negatives, and following bite injury, Eikenella and Pasteurella species. Atypical organisms especially in immunocompromised patients are increasingly being reported like fungi and slowly or rapidly growing mycobacteria. Management can be conservative with intravenous antibiotics and close monitoring especially in mild cases. Minimally invasive catheter irrigation of the tendon sheath can be used with improved functional outcomes.
Summary
Suppurative tenosynovitis is an infection of the tendon sheath. Inoculation usually occurs following injury, puncture wounds, bites, recent surgery, or via hematogenous or contiguous spread of infection. Kanavel signs are helpful when evaluating patients. Hand surgeons should be promptly consulted for decision about need for surgical exploration. Uncomplicated cases can be treated with 7 to 14 days of an oral antibiotic. Smoking, diabetes, vascular disease, and advanced Michon stage infection are associated with higher risk of amputation or decreased mobility. Infectious diseases specialists should be consulted in the management of atypical presentations like fungal and mycobacterial tenosynovitis.
Zusammenfassung
Mycobacterium haemophilum (MH) ist ein langsam wachsendes, nicht‐tuberkulöses Mykobakterium. Infektionen treten am häufigsten bei Patienten mit beeinträchtigtem Immunsystem auf; sie manifestieren sich meist an der Haut und kommen isoliert oder bei disseminierten Infektionen vor. Wir berichten hier über einen Fall mit isolierter MH‐Infektion an der Hand sowie über einen weiteren Fall von disseminierter MH‐Infektion mit multiplen Hautläsionen. Zusätzlich haben wir weitere Fallberichte über MH‐Infektionen mit kutaner Beteiligung aus den letzten zehn Jahren (2011–2022) ausgewertet. Die am häufigsten beobachteten Hautmanifestationen der insgesamt 79 Fälle waren Knötchen, Ulzera, Abszesse, Schwellungen und Pusteln. Patienten mittleren Alters mit iatrogener Immunsuppression durch Glucocorticoide, Mycophenolat‐Mofetil, Ciclosporin und Cyclophosphamid scheinen besonders anfällig für MH‐Infektionen zu sein und haben auch ein höheres Risiko für eine Dissemination in die inneren Organe. Disseminierte MH‐Infektionen manifestieren sich gewöhnlich als Tenosynovitis, Arthritis/Arthralgie oder Osteomyelitis. Derzeit gibt es keine starke Evidenz für bestimmte Therapeutika; in der Praxis wird am häufigsten eine Dreifachkombination aus Chinolon, Makroliden und Rifampicin eingesetzt. Die Prognose ist allgemein gut. Iatrogene Immunsuppression, Läsionen im proximalen Bereich der Extremitäten sowie disseminierte Manifestation sind mit schlechteren klinischen Verläufen assoziiert.
Mycobacterium haemophilum (MH) is a slow-growing, non-tuberculous Mycobacterium that most commonly causes infections in immunocompromised patients. The skin is the most prevalent site of infection and can be an isolated presentation or part of a disseminated disease. Herein, we reported a case of isolated MH infection of the hand and a case of disseminated MH infection with multiple skin lesions. In addition, other MH cases with cutaneous involvement over the last 10 years, from 2011-2022, were reviewed and analyzed. Among the 79 included cases, the common skin findings in MH infections included nodules, ulcers, abscesses, swelling, and pustules. Middle-aged patients with iatrogenic immunosuppression from glucocorticoids, mycophenolate mofetil, cyclosporine, and cyclophosphamide are the most susceptible to MH infection, with a higher risk of dissemination to internal organs. Disseminated MH infections commonly present as tenosynovitis, arthritis/arthralgia, or osteomyelitis. There is a lack of strong evidence for treatment; however, triple therapy of quinolone, macrolides, and rifampicin is most often used in clinical practice. The overall prognosis is good. The presence of iatrogenic immunocompromised diseases, lesions involving the proximal limbs, and dissemination of MH infections are associated with worse clinical outcomes.
The main characteristic of infections caused by mycobacteria is the presence of tuberculoid granuloma with chronic clinical evolution. Mycobacterioses can be divided into three groups of diseases: tuberculosis, leprosy, and non-tuberculous mycobacterioses (NTM). Cutaneous involvement by tuberculosis (Mycobacterium tuberculosis) is uncommon in both immunocompetent and immunosuppressed individuals. Hypersensitivity tuberculous reactions are rare in this population, as they are individuals undergoing chronic immunosuppression. Especially in endemic countries, leprosy (Mycobacterium leprae) can affect solid organ transplant recipients (SOTRs). An interesting aspect concerning leprosy is an inflammatory response decrease and leprosy reaction. Regarding NTM, SOTR is quite susceptible, both to mycobacteria that affect the skin and those that affect internal organs. SOTRs are frequently submitted to invasive procedures, so they are susceptible to mycobacteria cutaneous implantation.KeywordsTuberculosisLeprosy
Mycobacterium tuberculosis
Mycobacterium leprae
Non-tuberculous mycobacteriaMycobacteria other than tuberculosis
Objectives:
Sepsis is a life-threatening organ dysfunction caused by a host's unregulated immune response to eliminate the infection. After hospitalization, sepsis survivors often suffer from long-term impairments in memory, attention, verbal fluency, and executive functioning. To understand the effects of sepsis and the exacerbated peripheral inflammatory response in the brain, we asked the question: What are the findings and inflammatory markers in the brains of deceased sepsis patients? To answer this question, we conducted this systematic review by the recommendations of Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
Data sources:
Relevant studies were identified by searching the PubMed/National Library of Medicine, PsycINFO, EMBASE, Bibliographical Index in Spanish in Health Sciences, Latin American and Caribbean Health Sciences Literature, and Web of Science databases for peer-reviewed journal articles published on April 05, 2021.
Study selection:
A total of 3,745 articles were included in the primary screening; after omitting duplicate articles, animal models, and reviews, 2,896 articles were selected for the study. These studies were selected based on the title and abstract, and 2,772 articles were still omitted based on the exclusion criteria.
Data extraction:
The complete texts of the remaining 124 articles were obtained and thoroughly evaluated for the final screening, and 104 articles were included.
Data synthesis:
The postmortem brain had edema, abscess, hemorrhagic and ischemic injuries, infarction, hypoxia, atrophy, hypoplasia, neuronal loss, axonal injuries, demyelination, and necrosis.
Conclusions:
The mechanisms by which sepsis induces brain dysfunction are likely to include vascular and neuronal lesions, followed by the activation of glial cells and the presence of peripheral immune cells in the brain.
