Figure 1 - uploaded by Luís Arthur Brasil Gadelha Farias
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-Brain MRI with areas of hyperintensity in T2w-FLAIR on the bilateral periventricular white matter and leptomeningeal enhancement: (A) Sagittal plane; (B) and (C) Coronal plane. MRI = magnetic resonance imaging; T2w-FLAIR = T2-weighted fluid-attenuated inversion recovery.
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The global pandemic of COVID-19 is caused by the novel coronavirus SARS-CoV-2, which often causes flu-like symptoms and can progress to severe respiratory illness. Thus, as the disease spreads, COVID-19 cases have multiplied across the world, and manifestations involving multiple systems have been described. We report a case of COVID-19-associated...
Context in source publication
Context 1
... SARS-CoV-2 RNA was also amplified in CSF specimens using the CDC protocol 9 . Cranial magnetic resonance imaging (MRI) showed leptomeningeal enhancement and diffuse alteration of the bilateral periventricular white matter suggestive of encephalitis ( Figure 1). On day 9 of hospitalization, although the patient presented with neurological improvement, he developed new episodes of fever, cough and purulent sputum. ...
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Citations
... Коронавирусная инфекция может быть также ассоциирована с менингитом/энцефалитом, клинические характеристики которых требуют дальнейшего изучения [16]. К наиболее распространенным неврологическим проявлениям относились нарушение уровня сознания, ориентации во времени и пространстве. ...
В настоящее время описаны различные варианты поражений нервной системы, ассоциированные с коронавирусной инфекцией COVID-19. Особое внимание уделяется таким остро развивающимся заболеваниям, как менингоэнцефалиты, инсульты, судорожные припадки, моно- и полиневропатии, энцефалопатии. Несмотря на имеющееся на текущий момент большое количество публикаций, данная проблема требует дальнейшего тщательного изучения, что связано с необходимостью систематизации данных, выявления новых патогенетических механизмов и разработки оптимальных терапевтических подходов. Огромный интерес также вызывает возможность возникновения у 1 пациента нескольких вариантов острого поражения структур центральной и периферической нервной системы. В статье представлено описание собственного клинического наблюдения пациента, у которого развились серозный менингит и оптический неврит, ассоциированные с коронавирусной инфекцией COVID-19. На примере клинического наблюдения рассмотрены особенности течения заболевания, подходы к диагностике и лечению, а также возможные сложности в процессе дифференциально-диагностического поиска.
Nowadays, a variety of nervous system lesions associated with COVID-19 infection has been described. A special attention is paid to such acute developing diseases as meningoencephalitis, strokes, seizures, mono- and polyneuropathy, and encephalopathy. Despite the large number of available publications, this issue requires further careful study due to the necessity of systematizing data, identifying new pathogenetic mechanisms, and developing optimal therapeutic approaches. The possibility of several variants of acute damage to the structures of the central and peripheral nervous system in the same patient is also of great interest. The article describes the own clinical observation of a patient who developed serous meningitis and optic neuritis associated with COVID-19 infection. The clinical features of the disease course and approaches to diagnosis, as well as possible difficulties in the differential diagnostic process are considered.
We report a case of COVID-19-associated meningoencephalitis with a fatal outcome in a male patient with concomitant influenza A, who had been hospitalized at the beginning of 2022, in the Northeastern region of Brazil. He died due to cardiopulmonary arrest after developing status epilepticus on the third day of hospitalization. The SARS-CoV-2 RNA was detected in cerebrospinal fluid and Influenza A was detected in the nasopharyngeal swab. Meningoencephalitis due to COVID-19 is a rare manifestation and physicians must be aware of this complication, mainly during the pandemic. In viral co-circulation situations, the possibility of respiratory coinfections should be remembered.
COVID-19; Meningoencephalitis; Influenza A; Coinfection
Severe neurological disorders and vascular events during COronaVIrus Disease-2019 (COVID-19) have been described. Here, we describe the first case of a female patient infected with Omicron SARS-CoV-2 BA.2 Variant of Concern (VoC) meningitis with newly diagnosed central demyelinating disease.
