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Bone scan picture. (a) Pretreatment technetium-99 bone scan showing solitary increased uptake of radioisotope by L1 vertebra. (b) 6-month posttreatment technetium-99 bone scan showing significant reduction of radioisotope uptake by the affected vertebra b a
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Osteitis deformans, also known as Paget's disease, is characterized by accelerated osteoclastic activity followed by ineffective osteoblastic activity resulting in a deformed and fragile bone. It is more prevalent in Western Europe and relatively rare in Eastern Asia. It predominantly involves the lumbar spine, pelvis, and femur, frequently as poly...
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Metabolik kemik hastalıkları, metabolik açıdan aktif bir hemeostatik organ olarak rol alan kemik, osteoblast ve osteoklast fonksiyonlarında değişiklik sonucunda bozukluk olarak ortaya çıkar. Öncelikle omurga etkilenir; iskelet kemik kütlesinin önemli bölümünü temsil eder, metabolik açıdan aktif (kansellöz) en büyük kemiksel yapıdır, dik duruşta kom...
Bone remodeling is a key process in vertebrate organisms, since it is responsible for maintaining skeleton’s integrity. However, in some pathological conditions, such as osteoporosis or Paget’s disease, bone’s function becomes compromised. To gain a better understanding about these conditions, bone remodeling has become a determinant subject of res...
Paget's disease of bone is characterized by the dysfunction of the bone architecture due to the extreme increase of the osteoclast and osteoblast activity which results in the production of pathological bone. The particular disease afflicts any skeleton bone. Its sources have not been specified yet. There is evidence for the existence of strong gen...
