Bone marrow core biopsy involved with HST-CL shows hypercellularity displaying small and hypolobated megakaryocytes, morphologically consistent with dysmegakaryopoiesis, raising the possibility of underlying myelodysplastic syndrome.

Bone marrow core biopsy involved with HST-CL shows hypercellularity displaying small and hypolobated megakaryocytes, morphologically consistent with dysmegakaryopoiesis, raising the possibility of underlying myelodysplastic syndrome.

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The overview of the upcoming Blue Book of the 5th edition of the World Health Organization Classification of Hematolymphoid Tumors was published in Leukemia in June 2022. The updates on mature T-/NK-cell lymphomas and leukemias are organized in nine groups based on cell of origin, morphology, clinical scenario, and localization, and are highlighted...

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Context 1
... rare lymphoma is difficult to diagnose due to its well-known protean presentation, histopathology (Fig. 2, 3), phenotype and clinical aggressiveness; it is also a diagnosis that may portend allogenic stem cell transplant as the only means of achieving cure. Not only young, but also adult patients can be affected. HSTCL usually presents at stage IV. The diagnosis can be missed in a bone marrow that mimics a myelodysplastic syndrome, and the ...
Context 2
... rare lymphoma is difficult to diagnose due to its well-known protean presentation, histopathology (Fig. 2, 3), phenotype and clinical aggressiveness; it is also a diagnosis that may portend allogenic stem cell transplant as the only means of achieving cure. Not only young, but also adult patients can be affected. HSTCL usually presents at stage IV. The diagnosis can be missed in a bone marrow that mimics a myelodysplastic syndrome, and the ...